Glutathione S-transferase inhibitory, free radical scavenging, and anti-leishmanial activities of chemical constituents of Artocarpus nobilis and Matricaria chamomilla

Iverson, Chad D.; Zahid, Shamsulhaq; Li, Yimeng; Shoqafi, Ahmed H.; Ata, Athar; Samarasekera, Radhika

doi:10.1016/j.phytol.2010.07.008

Cited by 28 publications

(14 citation statements)

References 33 publications

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“…(Moraceae) resulted in the isolation of five known flavonoids, artonins E 16, artobiloxanthone 17, artoindonesianin U 18, cyclocommunol 19, and multiflorins A 20. Compounds 16-20 were significantly active in our GST inhibition assay with IC 50 values of 2.0, 1.0, 6.0, 3.0, and 4.0 μM, respectively [28]. These bioactivity data indicated that compounds 16-20 are more potent GST inhibitors than ethacrynic acid.…”

Section: Glutathione S-transferase Inhibitorsmentioning

confidence: 61%

Naturally occurring enzyme inhibitors and their pharmaceutical applications

Ata

Naz

Elias

2011

Pure and Applied Chemistry

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Enzyme inhibitors play a significant role in the drug discovery process. For instance, acetylcholinesterase (AChE) inhibitors have applications in curing Alzheimer's disease (AD), senile dementia, ataxia, myasthenia gravis, and Parkinson's disease. Glutathione S-transferase (GST) inhibitors have applications as adjuvants to overcome anticancer and antiparasitic drug resistance problems. Compounds inhibiting the activity of α-glucosidase are used to treat type 2 diabetes mellitus and obesity problems. This article describes the identification of natural products exhibiting AChE, GST, and α-glucosidase inhibitory activities from medicinally important plants. Additionally, structure-activity relationship (SAR) studies of these newly discovered enzyme inhibitors are also discussed.

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Section: Glutathione S-transferase Inhibitorsmentioning

confidence: 61%

Naturally occurring enzyme inhibitors and their pharmaceutical applications

Ata

Naz

Elias

2011

Pure and Applied Chemistry

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“…Threo-carolignan X (15) showed antioxidantscavenging effects on DPPH with an IC 50 of 28.4 μg/mL [64]. Fraxidin (20) showed antioxidant activity in the DPPH assay with IC 50 45.0 μg/mL [74], while scopoletin showed antioxidant activities of 63.8% and 70.2% against DPPH and H 2 O 2 , respectively, when tested at 45 g/mL [75]. Lastly, the benzoic derivative methyl protocatechuate (26) demonstrated antioxidant activity (DPPH) with an IC 50 value of 13.17 μg/mL [76].…”

Section: Secondary Metabolites: Phytochemical Investigation Of the Genusmentioning

confidence: 99%

Chemistry and Pharmacognosy of the Genus Durio

Rudiyansyaha

Panthong

Garson

2015

Natural Product Communications

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Durio is well known as one of the sources of seasonal fruit production in Southeast Asia with its center of diversity in Borneo. Thailand, Indonesia, and Malaysia are the main Durio producers in the world. Besides having much information about the utilization and benefit from its timber and fruits as a food substance, traditionally some parts of this plant, such as leaves, bark and root, can also be used for medical purposes. This review deals with chemical constituents and the biological activities of Durio plants.

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“…This genus received a great level of scientific interest as they contain medicinally important secondary metabolites possessing useful biological activities (Jagtap and Bapat, 2010). The Artocarpus species are rich in phenolic compounds including flavonoids, stilbenoids, arylbenzofurons, xanthone, etc (Arung et al, 2010;Hsu et al, 2011;Ko et al, 1998;Gwendoline et al, 2011;Iverson et al, 2010;Jayasinghe et al, 2004;Kai-Wei et al, 2009;Mohamed et al, 2009;Sato et al, 1996;Shuhartati et al, 2008;Wang et al, 2007). There are reports on essential oil components of some species (Ong et al, 2008;Wong et al, 1992).…”

Section: )mentioning

confidence: 99%

“…The effective concentration resulting in a 50% inhibition of the DPPH radical scavenging (EC 50 ) for the extracts was less than 100 μg/ml, except for twig extract with EC 50 value greater than 128 μg/ml. It is evident that A. nigrifolius extracts, like some Artocarpus species, did show some proton-donating ability and could serve as free radical scavengers (Donsing et al, 2008;Ko et al, 1998;Iverson et al, 2010;Jayasinghe et al, 2004;Kai-Wei et al, 2009).…”

Section: Antioxidant Activitymentioning

confidence: 99%

Antimicrobial, antioxidant activities and cytotoxicity evaluation of Artocarpus nigrifolius C. Y. Wu from Vietnam

Hoi¹,

Đài²,

Tra³

et al. 2013

Afr. J. Microbiol. Res.

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The extracts of leaf, stem bark, twigs and root of Artocarpus nigrifolius C. Y. Wu exhibited antibiotic activity against Bacillus subtilis, Staphylococcus aureus, Lactobacillus fermentum with the minimum inhibitory concentration value (IC 50 ) of 3.65, 5.49 and 4.25 µg/ml, respectively; but not with Escherichia coli, Pseudomonas aeruginosa and Candida albicans. The extract from stem bark shows a higher antioxidant activity (EC 50 ; 42.08 µg/ml) against DPPH than those of other extracts. Furthermore, the twig extract displayed significant cytotoxic activities against HepG2 and KB cell lines with IC 50 value of 10.06 and 19.21 µg/ml, respectively, in comparison with others. The leaves and stem bark exhibited moderate cytotoxic activities to KB (IC 50 ; 24.20 and 21.03 µg/ml, respectively) and MCF7 (IC 50 ; 22.68 and 21.10 µg/ml, respectively).

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Glutathione S-transferase inhibitory, free radical scavenging, and anti-leishmanial activities of chemical constituents of Artocarpus nobilis and Matricaria chamomilla

Cited by 28 publications

References 33 publications

Naturally occurring enzyme inhibitors and their pharmaceutical applications

Naturally occurring enzyme inhibitors and their pharmaceutical applications

Chemistry and Pharmacognosy of the Genus Durio

Antimicrobial, antioxidant activities and cytotoxicity evaluation of Artocarpus nigrifolius C. Y. Wu from Vietnam

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