Glutathione S -transferase (M1 and T1) and angiotensin-converting enzyme gene polymorphisms and chronic kidney disease in Bangladeshi population

A case-control study and systematic review of the association between glutathione S-transferase genes and chronic kidney disease

“…Glutathione-S-transferases (GSTs) are multifunctional enzymes, including GSTM1, GSTT1 and GSTP1, and their function is to neutralize endogenous oxidants and play a detoxifying role [ 10 ]. Defense against oxidative stress (OS) might be impaired due to reduced GST expression, and OS could be an alarming factor in the progression of CKD [ 13 ]. Deletions of GSTM1 and GSTT1 result in a lack of enzyme activities, and the G allele of GSTP1 (rs1695, p. Ile105Val) reduces its enzymatic activity by 50%–70 % compared to the wild-type [ [11] , [12] , [13] , [14] ].…”

“…Defense against oxidative stress (OS) might be impaired due to reduced GST expression, and OS could be an alarming factor in the progression of CKD [ 13 ]. Deletions of GSTM1 and GSTT1 result in a lack of enzyme activities, and the G allele of GSTP1 (rs1695, p. Ile105Val) reduces its enzymatic activity by 50%–70 % compared to the wild-type [ [11] , [12] , [13] , [14] ]. Many case‒control studies have been reported, and some of them showed significant associations between GST polymorphisms and CKD risk [ 10 , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] ].…”