1998
DOI: 10.1002/(sici)1097-0142(19980301)82:5<936::aid-cncr20>3.3.co;2-w
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Glutathione S‐transferase M1 and T1 and cytochrome P4501A1 polymorphisms in relation to the risk for benign and malignant head and neck lesions

Abstract: The occurrence of polymorphic variants in the GSTM1, GSTT1, and CYP1A1 genes did not differ between the groups investigated, therefore indicating no significant contribution to the development of head and neck cancer.

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Cited by 23 publications
(42 citation statements)
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“…28,[35][36][37][38] Several studies have associated the GST-M1/GST-T1 null genotypes with an increased risk for HNSCC, 28,39 -42 whereas other studies have failed to identify this relation. 43,44 Unal et al 34 implicated the GST-T1 null genotype as a risk factor for laryngeal squamous cell carcinoma but failed to implicate the GST-M1 null genotype. Ko et al 28 reported a synergistic effect of CYP1B1, GST-M1, and GST-T1 but concluded that the GST-M1/GST-T1 null genotypes alone were not independent risk factors for HNSCC.…”
Section: Discussionmentioning
confidence: 99%
“…28,[35][36][37][38] Several studies have associated the GST-M1/GST-T1 null genotypes with an increased risk for HNSCC, 28,39 -42 whereas other studies have failed to identify this relation. 43,44 Unal et al 34 implicated the GST-T1 null genotype as a risk factor for laryngeal squamous cell carcinoma but failed to implicate the GST-M1 null genotype. Ko et al 28 reported a synergistic effect of CYP1B1, GST-M1, and GST-T1 but concluded that the GST-M1/GST-T1 null genotypes alone were not independent risk factors for HNSCC.…”
Section: Discussionmentioning
confidence: 99%
“…Some of these studies suggested that there was the lack of association between the GSTM1 gene polymorphism and the development of laryngeal cancer and head and neck cancer [22][23][24] whereas, another study showed that the GSTM1 null genotype is a risk factor for development of laryngeal cancer [5]. Differences in the results of the previous studies may due to different samples analyzed for the polymorphism studies such as using lymphocytes [22,25] or tissue samples [26]. Our results show that the null genotype of GSTM1 was not found to be associated with development of laryngeal cancer.…”
Section: Discussionmentioning
confidence: 99%
“…In addition to the Cheng et al (1999) report, the MD Anderson group have previously reported a significant association between SCCHN and the GSTT1 null genotype (OR ϭ 2.52, , but in that study they did not observe an increased risk of SCCHN in association with GSTM1 nullizygosity alone. Other studies of oral cancer (Deakin et al, 1996), laryngeal cancer (Jahnke et al, 1996;Jourenkova et al, 1998), and of all SCCHN sites combined (Ophuis et al, 1998) showed no significant excess of GSTT1 null genotypes among cases compared to controls. However, the subjects in these studies were not stratified with respect to tobacco or alcohol exposure, or closely matched for ethnicity, with the exception of one study (Jourenkova et al, 1998) where a non-significantly increased risk of laryngeal cancer among long-term smokers as well as an increased risk in individuals lacking both GSTM1 and GSTT1 were reported.…”
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confidence: 84%