Glutathione S-transferase M1 and T1 null genotype distribution in South Indians

Naveen, Amrithraj Theophilus; Chandrasekaran, Adithan; Padmaja, N.; Shashindran, C. H.; Abraham, Benny K.; Satyanarayanamoorthy, K.; Anitha, P.; Gérard, Nathalie; Krishnamoorthy, R. V.

doi:10.1007/s00228-004-0779-3

Cited by 36 publications

(34 citation statements)

References 13 publications

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“…Prevalence of null genotypes in GSTM1 and/or both GSTT1 genes in our population is comparable with that found in other Indian studies (26,27). As a result of deletions in one or both of these loci and, consequently, less detoxification of xenobiotic toxic substances, an individual may become susceptible to diseases produced by toxic substances present in the environment; hence, finding a positive correlation raises the possibility that the two enzymes are working in tandem rather than in a complementary way.…”

Section: Discussionsupporting

confidence: 91%

Comparative study of GST polymorphism in relation to age in COPD and lung cancer

Shukla

Kant²,

Mittal³

et al. 2013

Tuberk Toraks

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ÖZET KOAH ve akciğer kanserinde yaşla ilişkili olarak GST polimorfizmi karşılaştırmalı çalışma (OR= 1.87; 95%; p= 0.002). GSTM1 null akciğer kanseriyle ilişkili bulunmadı. Alt grup analizinde GSTM1 null polimorfizmi [46][47][48][49][50][51][52][53][54][55][56][57][58][59][60][61][62][63][64][65] OR= 3.20; 95%; p= 0.001), akciğer kanserli hastalar ile kontrol arasında aynı yaş grubunda fark yoktu (55.6%/44.4% OR= 1.07; p= 0.774

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Section: Discussionsupporting

confidence: 91%

Comparative study of GST polymorphism in relation to age in COPD and lung cancer

Shukla

Kant²,

Mittal³

et al. 2013

Tuberk Toraks

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“…Number of female smokers was very less, so it was not possible to compare the results between both the genders. No significant differences were observed between smokers and non-smokers, alcoholic and non-alcoholic individuals, tobacco chewers and non-chewers, carrying homozygous GSTM1/GSTT1/GSTM1T1 null genotype (p>0.05) ( Anantharaman, 2007;Buch et al, 2002;Nair et al, 1999 South Indians c 1744 485 (27.8)** 242 (13.9) 136 (7.8) Naveen et al, 2004;Samson, 2007;Shehnaz et al, 2011;Sreelekha et al, 2001;Suneetha, 2011;Vettriselvi et al, 2006;Vijayalakshmi et al, 2005 East Indians d 67 18(27.0) 9 (13.0) Sikdar et al, 2005 Central Indians e 282 99 (35.1) 37 (13.0) Devi et al, 2008 North Nair et al, 1999;Singh et al, 2009 Blacks b 3008 960 (31.9) 744 (24.9)* 298 (9.9)* Adams et al, 2003;Benzamin et al, 2011;Coutinho et al, 2010;Dandara et al, 2002;Lavender et al, 2009;Masimirembwa et al, 1998;Millikan et al, 2000;Rossini et al, 2002 Caucasians c 2674 1064/2232 (47.7)* 448/2674 (16.7) 31 (9.3) Amer et al, 2011;Baranova et al, 1997;Chen et al, 1996;D'Alo et al, 2004;Gsur et al, 2001;Kargas et al, 2003;Millikan et al, 2000;Mitrunen et al, 2001;Steinhoff et al, 2000;Welfare et al, 1999 Asians 1). The frequency distribution of GSTM1 and GSTT1 alleles were compared between different states of India and other populations all over the world (Table 2 and 3).…”

Section: Resultsmentioning

confidence: 99%

Genetic Polymorphisms of GSTM1 and GSTT1 Genes in Delhi and Comparison with other Indian and Global Populations

Sharma¹,

Pandey²,

Sardana³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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The glutathione S-transferases (GSTs) are involved in the metabolism of many xenobiotics, including an array of environmental carcinogens, pollutants, and drugs. Genetic polymorphisms in these genes may lead to interindividual variation in susceptibility to various diseases. In the present study, GSTM1 and GSTT1 polymorphisms were analysed using a multiplex polymerase chain reaction in 500 normal individuals from Delhi. The frequency of individuals with GSTM1 and GSTT1 null genotypes were 168 (33.6%) and 62 (12.4%) respectively, and 54(10.8%) were having homozygous null genotype for both the genes GSTM1 and GSTT1simultaneously. The studied population was compared with reported frequencies from other neighbouring state populations, as well as with those from other ethnic groups; Europeans, Blacks, and Asians. The prevalence of homozygous null GSTM1 genotype is significantly higher in Caucasians and Asians as compared to Indian population. The frequency of GSTT1 homozygous null genotypes is also significantly higher in blacks and Asians. We believe that due to large number of individuals in this study, our results are reliable estimates of the frequencies of the GSTM1, GSTT1 in Delhi. It would provide a basic database for future clinical and genetic studies pertaining to susceptibility and inconsistency in the response and/or toxicity to drugs known to be the substrates for GSTs.

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“…GSTM1 null allele frequency of Gujaratians (20%) was not significantly different to other Indian ethnic's frequency of 23% to 33% but GSTT1 null frequency (35.5%) was significantly different (Table 6) from 13% to 19.1% of various Indian populations reported earlier (Roy et al, 1998;Buch et al, 2001;Mishra et al, 2004;Naveen et al, 2004;Vetriselvi et al, 2006;Konwar et al, 2010).…”

Section: Null Type Frequency Of Gstm1 and Gstt1 Among Indian Populationsmentioning

confidence: 58%

“…The frequency of GSTT1 null genotype in Gujaratians was high among the other population with low tobacco usage (Rani et al, 2003). And it might be due to high tobacco usage in both chewing and smoking forms among the subjects than the other populations in India (Roy et al, 1998;Buch et al, 2001;Mishra et al, 2004;Naveen et al, 2004;Vetriselvi et al, 2006;Konwar et al, 2010). GSTM1 null frequency among different population in India was not significantly different to Gujaratians, as the influence was moderate due to smoking tobacco form alone and not by chewing form.…”

Section: Discussionmentioning

confidence: 98%

“…The age old customary habituate of high tobacco usage among Gujarat population was considered as the suitable subject for the study among Indian ethnics reported earlier (Rani et al, 2003). Further we compared the frequency rate of GST polymorphism among the subjects with the low tobacco using other populations within India, reported by various investigators (Roy et al, 1998;Buch et al, 2001;Mishra 5038 et al, 2004;Naveen et al, 2004;Vetriselvi et al, 2006;Konwar et al, 2010).…”

Section: Impact Of Tobacco On Glutathione S Transferase Gene Loci Of mentioning

confidence: 99%

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Impact of Tobacco on Glutathione S Transferase Gene Loci of Indian Ethnics

Senthilkumar¹,

Ramasamy²

2012

Asian Pacific Journal of Cancer Prevention

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Background: Tobacco contains agents which generate various potent DNA adducts that can cause gene mutations. Production of DNA adducts may be neutralized by glutathione S transferase (GST) along with other phase I and phase II enzyme systems. The existence of null type of GST among the population increases the susceptibility to various disorders and diseases. The present study focuses on the impact of high tobacco usage and possible null type mutation in GST loci. Methods: Genotypes of GST were detected by multiplex polymerase chain reaction in unrelated 504 volunteers of high tobacco using natives of Gujarat. Allelic frequencies were calculated using Statistical Package for Social Studies-16 software. Hardy Weinberg Equilibrium (HWE) was calculated using Chi square test. Two sided Fisher's significance test was used to compare allelic frequencies of different populations. Results: The frequency of homozygous null genotype of GSTM1 and GSTT1 were 20% (95% CI 16.7-23.9) and 35.5% (95% CI 31.4-39.9) respectively. The GSTM1 and GSTT1 null allele frequency distribution in the Gujarat population was significantly deviating from HWE. GSTT1 null frequency of Gujaratians was significantly higher and different to all reported low tobacco using Indian ethnics, while GSTM1 was not differing significantly. Conclusion: Tobacco usage significantly influences the rate of mutation and frequency of GSTT1 and M1 null types among the habituates. The rate of mutation in GSTT1 loci was an undeviating response to the dose of tobacco usage among the population. This mutational impact of tobacco on GSTT1 postulates the possible gene -environment interaction and selection of null genotype among the subjects to prone them under susceptible status for various cancers and even worst to cure the population with GSTT1 dependent drugs.

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Glutathione S-transferase M1 and T1 null genotype distribution in South Indians

Abstract: The prevalence of the GSTM1 null genotype differed within India. The frequency of GSTM1 null in South Indians was significantly lower than that in Caucasians. The frequencies of both GSTM1 and GSTT1 null genotypes in South Indians were significantly lower than in the Japanese.

Cited by 36 publications

References 13 publications

Comparative study of GST polymorphism in relation to age in COPD and lung cancer

Comparative study of GST polymorphism in relation to age in COPD and lung cancer

Genetic Polymorphisms of GSTM1 and GSTT1 Genes in Delhi and Comparison with other Indian and Global Populations

Impact of Tobacco on Glutathione S Transferase Gene Loci of Indian Ethnics

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