Glutathione S-transferase M1 polymorphism may contribute to schizophrenia in the Korean population

Pae, Chi‐Un; Yu, Hye-Sook; Kim, Jung-Jin; Kim, Won; Lee, Chang-Uk; Lee, Soo-Jung; Jun, Tae‐Youn; Lee, Chul; Paik, In‐Ho; Serretti, Alessandro

doi:10.1097/00041444-200409000-00005

Cited by 34 publications

(26 citation statements)

References 20 publications

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“…Although the exact function of BanI polymorphism cPLA2 gene still requires further investigation, PLA2 are enzymes involved in phospholipids metabolism, cell membrane remodeling and intracellular signaling, while cPLA2 is responsible for release of AA and EPA from cell membrane. Moreover, BanI polymophism has been associated with increased cPLA2 activity in both patients with psychiatric disorders including MDD [19] and schizophrenia [26], which further implies MDD may be associated with disordered metabolism of phospholipids and inflammatory process. In addition, cPLA2 BanI polymorphism may be associated with somatic symptoms in MDD via the changes in EPA levels.…”

Section: Discussionmentioning

confidence: 99%

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BanI polymorphism of cytosolic phospholipase A2 gene and somatic symptoms in medication-free acute depressed patients

Chang

Guu

Chen

et al. 2018

Prostaglandins, Leukotrienes and Essential Fatty Acids

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Somatic symptoms are commonly seen in patients with major depressive disorder (MDD) and might be associated with inflammatory activation. Cytosolic phospholipase A2 (cPLA2) and cyclo-oxygenase-2 (COX-2) are the key enzymes in the metabolism of polyunsaturated fatty acids (PUFAs), which in turn may play an important role in inflammation and somatic symptoms in depression. This study investigated the effects of BanI polymorphism of cPLA2 gene and COX-2 rs4648308 genotypes on somatic symptoms and inflammatory marker in patients with MDD.Eighty-two patients with MDD were assessed for their psychopathology including 2 psychiatric and somatic symptoms, BanI polymorphism of cPLA2 and COX-2 rs4648308 genotypes and CRP levels. The results revealed that MDD patients with the cPLA2 BanI GG genotypes had higher somatic symptoms and higher levels of C-reactive protein (CRP), while no differences were found among the COX-2 rs4648308 genotypes. Inflammatory process, such as arachidonic acid cascade pathway, might help explain the effect of cPLA2 BanI polymorphism on the somatic symptoms, and may be a potential target for future investigation on treatment for MDD with somatic symptoms. However, the interpretation of the findings in this study is limited since we analyzed the data from a subset data from a larger study.

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Section: Discussionmentioning

confidence: 99%

“…were associated with schizophrenia [24][25][26][27]. Moreover, MDD [19] and IFN-αinduced depression associated somatic symptoms [21] have been associated with GG genotype of BanI polymorphism of the cPLA2 gene, while development of major depression has been associated with COX-2 rs4648308 AG genotype [21].…”

Section: Introductionmentioning

confidence: 99%

BanI polymorphism of cytosolic phospholipase A2 gene and somatic symptoms in medication-free acute depressed patients

Chang

Guu

Chen

et al. 2018

Prostaglandins, Leukotrienes and Essential Fatty Acids

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“…GSTM1 and GSTP1 on the other hand, belong to a family of enzymes (glutathione S-transferases) involved in xenobiotic detoxification by means of conjugating glutathione [McLellan et al, 1997]. GSTM1 is the one of the most frequently studied genes related to lung cancer susceptibility [Carlsten et al, 2008] and recent work has also implicated it in schizophrenia [Harada et al, 2001;Pae et al, 2004].…”

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confidence: 99%

Genetic association studies of methamphetamine use disorders: A systematic review and synthesis

Bousman

Glatt

Everall

et al. 2009

American J of Med Genetics Pt B

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Efforts to understand the biological processes that increase susceptibility to methamphetamine (METH) use disorders (i.e., abuse, dependence, and psychosis) have uncovered several putative genotypic variants. However, to date a synthesis of this information has not been conducted. Thus, systematic searches of the current literature were undertaken for genetic-association studies of METH use disorders. Each gene's chromosomal location, function, and examined polymorphic markers were extracted. Frequencies, odds ratios and 95% confidence intervals for risk alleles, as well as sample size and power, were calculated. We uncovered 38 studies examining 39 genes, of which 18 were found to have a significant genotypic, allelic, and/or haplotypic association with METH use disorders. Three genes (COMT, DRD4, and GABRA1) were associated with METH abuse, nine (ARRB2, BDNF, CYP2D6, GLYT1, GSTM1, GSTP1, PDYN, PICK1, and SLC22A3) with METH dependence, two (AKT1 and GABRG2) with METH abuse/dependence, and four (DTNBP1, OPRM1, SNCA, and SOD2) with METH psychosis. Limitations related to phenotypic classification, statistical power, and potential publication bias in the current literature were noted. Similar to other behavioral, psychiatric, and substance use disorders, the genetic epidemiology of METH use disorders is complex and likely polygenic. National and international collaborative efforts are needed to increase the availability of large population-based samples and improve upon the power to detect genetic associations of small magnitude. Further, replication of the findings reviewed here along with further development of more rigorous methodologies and reporting protocols will aid in delineating the complex genetic epidemiology of METH use disorders.

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“…25 Null mutations of GSTM1 are associated with a diverse set of chronic conditions, [26][27][28][29][30] and a reduction in the enzyme product is associated with increased oxidative stress and hypertension in both animal models 31 and elderly human patients. 32 In NPHS-II, we observed duplication CNVs in GSTM1 at Chr1:110034988 and Chr1:110036093, which were associated with lower plasma apoAI.…”

Section: Discussionmentioning

confidence: 99%

Gene-Targeted Analysis of Copy Number Variants Identifies 3 Novel Associations With Coronary Heart Disease Traits

Costelloe

Moustafa

Drenos

et al. 2012

Circ Cardiovasc Genet

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Background— Copy number variants (CNVs) are a major form of genomic variation, which may be implicated in complex disease phenotypes. However, investigation of the role of CNVs in coronary heart disease (CHD) traits has been limited. Methods and Results— We examined the use of the cnvHap algorithm for CNV detection, using data for 2500 men from the Second Northwick Park Heart Study (NPHS-II). An Illumina custom chip, including 722 single-nucleotide polymorphisms covering 76 coronary heart disease-trait genes, was used. Common CNVs were significantly associated (at P <0.05, after correction) with coronary heart disease phenotypes in 5 genes. Novel associations of CNVs in toll-like receptor-4 with apolipoprotein AI were replicated ( P <0.05) in the Whitehall II cohort (4887 subjects), whereas newly described associations of CNVs in sterol regulatory element-binding protein with apolipoprotein AI and associations of interleukin-6 signal transducer with apolipoprotein B were replicated in the data from 3546 subjects from the North Finnish Birth Cohort 1966 ( P <0.05). Conclusions— This study supports the use of CNV detection algorithms such as cnvHap as potential tools for the identification of novel CNVs, some of which show significant association and replication with coronary heart disease risk phenotypes. However, the functional basis for these associations requires further substantiation.

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Glutathione S-transferase M1 polymorphism may contribute to schizophrenia in the Korean population

Cited by 34 publications

References 20 publications

BanI polymorphism of cytosolic phospholipase A2 gene and somatic symptoms in medication-free acute depressed patients

BanI polymorphism of cytosolic phospholipase A2 gene and somatic symptoms in medication-free acute depressed patients

Genetic association studies of methamphetamine use disorders: A systematic review and synthesis

Gene-Targeted Analysis of Copy Number Variants Identifies 3 Novel Associations With Coronary Heart Disease Traits

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