Glutathione S-transferase P1 (GSTP1) polymorphism in patients with chronic obstructive pulmonary disease

Ishii, Takeo; Matsuse, Takeshi; Teramoto, Shinji; Matsui, Hotaka; Miyao, Mariko; Hosoi, Takayuki; Takahashi, Hiroyuki; Fukuchi, Yoshinosuke; Ouchi, Yasuyoshi

doi:10.1136/thx.54.8.693

Cited by 164 publications

(119 citation statements)

References 25 publications

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“…The data remain inconsistent (Harries et al, 1997;Ishii et al, 1999;Cheng et al, 2004;Rodríguez et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Relationship between glutathione S-transferase P1 polymorphisms and chronic obstructive pulmonary disease in a Tunisian population

Lakhdar¹,

Denden²,

Knani³

et al. 2010

Genet. Mol. Res.

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ABSTRACT. Chronic obstructive pulmonary disease (COPD) is a multifactorial disease with possible genetic predisposition and involvement of various environmental factors. Several candidate genes have been reported as potentially associated with this lung disease. The glutathione S-transferase P1 gene (GSTP1) was proposed to be involved in susceptibility to develop COPD. It belongs to the GST family, which is a group of phase II enzymes that catalyze the glutathione conjugation of many endogenous and exogenous electrophilic compounds, such as carcinogens, therapeutic drugs, environmental toxins, and oxidative stress products. We conducted a case-control study to investigate genetic polymorphisms of this enzyme [exon 5 (Ile105Val) and exon 6 (Ala114Val)] in 234 unrelated COPD cases and 182 healthy controls from a Tunisian population. Genotyping was carried out using polymerase chain reaction and restriction fragment length polymorphism methods. GSTP1 Ala114/ Val114 and Val114/Val114 genotypes were not found in either patients or healthy controls. However, there were differences in the distribution of various exon 5 GSTP1 genotypes between COPD patients and healthy controls. GSTP1 Val105/Val105 was significantly more common in patients compared to controls (OR = 2.67; 95%CI = 1.45-4.92; P = 0.0013). Multivariate logistic regression analysis confirmed a significant relationship between the mutant genotype and COPD (OR = 2.58; 95%CI = 1.31-5.09; P = 0.026), after adjustment for classic risk factors. Analysis of variance showed no correlation between age, body-mass index, pack-years, percentage of predicted FEV1 values, and any of the GSTP1 genotypes. We conclude that subjects with GSTP1 Val105 allele are at higher risk of COPD.

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“…The data remain inconsistent (Harries et al, 1997;Ishii et al, 1999;Cheng et al, 2004;Rodríguez et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Relationship between glutathione S-transferase P1 polymorphisms and chronic obstructive pulmonary disease in a Tunisian population

Lakhdar¹,

Denden²,

Knani³

et al. 2010

Genet. Mol. Res.

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“…23 Most polymorphisms were genotyped using a PCR-restriction fragment length polymorphism-based technique, [24][25][26][27][28][29][30][31][32][33] except for variants of CYP2E1 (96 bp), 34 TP53 (16 bp),…”

Section: à2mentioning

confidence: 99%

Genetic polymorphisms and the efficacy and toxicity of cisplatin-based chemotherapy in ovarian cancer patients

Khrunin

Moisseev²,

Gorbunova³

et al. 2009

Pharmacogenomics J

166

139

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Platinum drugs are among the most active and widely used agents in the treatment of different cancers. However, the great individual variability in both outcome and toxicity of platinum chemotherapy requires the identification of genetic markers that can be used to screen patients before treatment. In this study, 21 polymorphisms in 10 genes, the protein activities of which may be addressed in different aspects of cisplatin metabolism, were tested for correlations with efficacy and toxicity of cisplatin-cyclophosphamide regimen in 104 ovarian cancer patients. The glutathione S-transferase P1 (GSTP1) Ile105Val polymorphism was strongly associated with progression-free survival (w 2 ¼ 12.12, P ¼ 0.002). The allelic status of the GSTA1 -69 C4T polymorphism correlated with the overall survival: patients with T/T genotype survived longer than C/C carriers (P ¼ 0.044). Thrombocytopenia, anemia and neuropathy were less frequent among patients with the GSTM1-null or GSTM3 intron 6 AGG/AGG genotypes. Severe neutropenia was associated with the TP53 72 Pro/Pro, XPD 312 Asp/Asn and XRCC1 399 Arg/Arg genotypes. A higher risk of nephrotoxicity was noted for patients with the heterozygous ERCC1 19007 T/C and 8092 C/A genotypes. No correlations were found between genotypes and complete tumor responses.

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“…Нуклеотидная замена C341T приводит к замене аминокислоты аланин на валин (ala/val) в 114-м положе-нии пептида. Обе мутации находятся в активном центре фермента и значительно снижают его функциональную активность (Ishii et al, 1999). Вышеперечисленные нук-лео тидные замены приводят к появлению четырех алле-лей гена GSTP1 -A, B, C, D. Аллель А -«дикого» типа, кодирует «активный» вариант фермента, аллели B, C, D имеют нуклеотидные замены и кодируют «медленные» варианты белка (Watson et al, 1998).…”

Section: популяционная генетикаunclassified

Glutathione S-transferase polymorphism in ethnic groups living in Eastern Siberia

Belyaeva¹,

Yershova²,

Astahova³

et al. 2017

Vestn. VOGiS

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The role of glutathione S-transferase for the life of the cell and the entire organism is related to their participation in the processes of detoxification of xenobiotics and antioxidant protection. Genetic variability of glutathione S-transferases appears in the form of different enzymatic activity of the corresponding protein products. In this study, a comparative analysis was conducted on the frequency of genotypes of three genes in the glutathione S-transferases gene superfamily (GSTM1, GSTT1, GSTP1) from representatives of two ethnic groups, Russian and Buryat. To this end, genetic typing of DNA samples was performed by polymerase chain reaction. Statistically significant differences in the frequency of occurrence of allel es A, B, C of the GSTP1 gene (р = 0.026) were found between the groups of teenagers compared. It was found that the frequency of the allele A, which codes for the active variant enzyme, is significantly higher in the Buryat ethnic group (p = 0.012). The allele B, the product of which is a "slow" version of the enzyme, was significantly more common in the Russian ethnic group (p = 0.014). In the GSTM1 and GSTT1 genes, no statistically significant differences in the frequency of occurrence of "zero" and "functional" genotypes between the compared groups of teenagers were found. however, there was a tendency to increase in the frequency of the "zero" genotype of the GSTM1 gene in the Russian ethnic group. In addition, the frequency of the "zero" genotype in two genes GSTM1 and GSTT1 at once was almost two times higher in the Russian ethnic group than in the Buryat ethnic group.Key words: glutathione S-transferase; gene polymorphism; ethnic groups; teenagers.Роль глутатион-S-трансфераз в жизнедеятельности клетки и всего организма связана с их участием в процессах детоксикации ксе-но биотиков и антиоксидантной защите. Генетическая вариабель-ность генов глутатион-S-трансфераз проявляется в различной ферментативной активности соответствующих белковых продук-тов. В работе представлен сравнительный анализ частоты аллелей и генотипов трех генов суперсемейства глутатион-S-трансфераз (GSTM1, GSTT1, GSTP1) у подростков из двух этнических групп -русских и бурят. Для этого было проведено генотипирование об-разцов ДНК методом полимеразной цепной реакции. Показано, что между сравниваемыми группами подростков наблюдаются статистически значимые различия по частоте встречаемости алле-лей A, B, C гена GSTP1 (р = 0.026). Аллель «дикого» типа A, кодиру-ющий «активный» вариант фермента, чаще встречается у коренно-го населения, в этногруппе бурят (p = 0.012). Аллель В, продуктом которого является «медленный» вариант фермента, напротив, чаще отмечается у пришлого населения, в этногруппе русских (р = 0.014). По генам GSTM1 и GSTT1 статистически значимых раз-личий по частоте встречаемости «нулевых» и «функциональных» генотипов между сравниваемыми группами не обнаружено. Тем не менее отмечена тенденция увеличения частоты «нулевого» генотипа гена GSTM1 у пришлого населения; кроме этого, частота «нулевого» генотипа одн...

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Glutathione S-transferase P1 (GSTP1) polymorphism in patients with chronic obstructive pulmonary disease

Cited by 164 publications

References 25 publications

Relationship between glutathione S-transferase P1 polymorphisms and chronic obstructive pulmonary disease in a Tunisian population

Relationship between glutathione S-transferase P1 polymorphisms and chronic obstructive pulmonary disease in a Tunisian population

Genetic polymorphisms and the efficacy and toxicity of cisplatin-based chemotherapy in ovarian cancer patients

Glutathione S-transferase polymorphism in ethnic groups living in Eastern Siberia

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