Glutathione-S-Transferase Polymorphisms (GSTM1, GSTT1 and GSTP1) and Acute Leukemia Risk in Asians: a Meta-analysis

Glutathione-S-transferase polymorphism and acute lymphoblastic leukemia (ALL) in north Indian children: a case–control study and meta-analysis

“…Our findings pertaining to the GSTM1 genotype is in agreement with all the previously conducted meta-analyses, 3,[32][33][34][35][36] while that pertaining to GSTT1 compared favorably with some 33,34 while disagreeing with others. 32,35,36 None of the earlier meta-analyses found any association between GSTP1 polymorphism and risk of childhood ALL. 3,33,36 The presence of significant association of childhood ALL with both GSTM and GSTT among Asians, as seen in our study was noted by earlier studies as well.…”

“…32,35,36 None of the earlier meta-analyses found any association between GSTP1 polymorphism and risk of childhood ALL. 3,33,36 The presence of significant association of childhood ALL with both GSTM and GSTT among Asians, as seen in our study was noted by earlier studies as well. [34][35][36] The reason behind this finding may be different genetic susceptibility of Asians as well as excessive exposure to environmental toxins in Asian children as compared with others, 37 which may be reflective of the rapid rate of industrialization of Asian countries near the time when these studies were conducted.…”

“…We searched for indexed publications in Pubmed and Medline databases whereas Google Scholar was searched to locate articles in un-indexed locations. In fact one Indian study 9 found in such an un-indexed location was not included by the authors of the earlier metaanalyses 3,32-35 on this subject, except one 36 which studied the association of GST genes with acute leukemia among Asians only.…”

“…We combined 22, 10 and 20 studies each for GSTM1, GSTP1 and GSTT1 genes respectively including larger number of subjects compared with the previous meta-analyses. 3,[32][33][34][35][36] We also noted a considerable lack of studies among Black subjects, only two studies examined the association of GSTM1 and GSTT1 in a limited number of Black subjects (n ¼ 473). No GSTP1-related study conducted among the Blacks was noted by us.…”

Impact of the Ile105Val Polymorphism of the Glutathione S-transferase P1 (GSTP1) Gene on Obesity and Markers of Cardiometabolic Risk in Young Adult Population

“…In addition, significant differences in the frequency of the genotype (Isoleucina 105 Valina) between healthy patients and the diabetic control group were observed, corroborating the hypothesis that allele G (Valine) of GSTP1 would have a major role in the predisposition to DM2 [7]. Other investigations also demonstrated an association between GSTP1 gene polymorphism and several chronic diseases, such as cancer [8,9], coronary artery disease [10] and cystic fibrosis [11].…”