Glutathione transferase isozyme genotypes in patients with prostate and bladder carcinoma

Abstract

Genotype distributions for GSTP1, GSTM1, and GSTT1 were determined in 91 patients with prostatic carcinoma and 135 patients with bladder carcinoma and compared with those in 127 abdominal surgery patients without malignancies. None of the genotypes differed significantly with respect to age or sex among controls or cancer patients. In the group of prostatic carcinoma patients, GSTT1 null allele homozygotes were more prevalent (25% in carcinoma patients vs. 13% in controls, Fisher P =0.02, chi2 P=0.02, OR=2.31, CI = 1.17-4.59) and the combined M1-/T1 -null genotype was also more frequent (9% vs. 3%, chi2 P=0.02, Fisher P = 0.03). Homozygosity for the GSTM1 null allele was more frequent among bladder carcinoma patients (59% in bladder carcinoma patients vs 45% in controls, Fisher P=0.03, chi2 P=0.02, OR=1.76, CI=1.08-2.88). In contrast to a previous report, no significant increase in the frequency of the GSTP1b allele was found in the tumor patients. Except for the combined GSTM1-/ T1-null genotype in prostatic carcinoma, none of the combined genotypes showed a significant association with either of the cancers. These findings suggest that specific single polymorphic GST genes, that is GSTM1 in the case of bladder cancer and GSTT1 in the case of prostatic carcinoma, are most relevant for the development of these urological malignancies among the general population in Central Europe.

Genetic Polymorphisms of GSTM1 and GSTT1 Genes in Delhi and Comparison with other Indian and Global Populations

“…Number of female smokers was very less, so it was not possible to compare the results between both the genders. No significant differences were observed between smokers and non-smokers, alcoholic and non-alcoholic individuals, tobacco chewers and non-chewers, carrying homozygous GSTM1/GSTT1/GSTM1T1 null genotype (p>0.05) ( Anantharaman, 2007;Buch et al, 2002;Nair et al, 1999 South Indians c 1744 485 (27.8)** 242 (13.9) 136 (7.8) Naveen et al, 2004;Samson, 2007;Shehnaz et al, 2011;Sreelekha et al, 2001;Suneetha, 2011;Vettriselvi et al, 2006;Vijayalakshmi et al, 2005 East Indians d 67 18(27.0) 9 (13.0) Sikdar et al, 2005 Central Indians e 282 99 (35.1) 37 (13.0) Devi et al, 2008 North Nair et al, 1999;Singh et al, 2009 Blacks b 3008 960 (31.9) 744 (24.9)* 298 (9.9)* Adams et al, 2003;Benzamin et al, 2011;Coutinho et al, 2010;Dandara et al, 2002;Lavender et al, 2009;Masimirembwa et al, 1998;Millikan et al, 2000;Rossini et al, 2002 Caucasians c 2674 1064/2232 (47.7)* 448/2674 (16.7) 31 (9.3) Amer et al, 2011;Baranova et al, 1997;Chen et al, 1996;D'Alo et al, 2004;Gsur et al, 2001;Kargas et al, 2003;Millikan et al, 2000;Mitrunen et al, 2001;Steinhoff et al, 2000;Welfare et al, 1999 Asians 1). The frequency distribution of GSTM1 and GSTT1 alleles were compared between different states of India and other populations all over the world (Table 2 and 3).…”

Tumour-stroma interactions between metastatic prostate cancer cells and fibroblasts

“…3) and epidemiological studies suggest factors in Western life style to contribute to its development (4,5). Linkage analyses point to hereditary prostate cancer genes (6,7) and polymorphisms of so-called modifier genes (related to hormone response, cell protection or DNA repair) may increase the risk of prostate carcinoma (7)(8)(9). Several proto-oncogenes such as myc (10), EIF3S3 (11), bcl2 (12) or growth factor encoding genes (13) have been identified.…”

Interacciones genéticas y genético-ambientales como efecto modificador del riesgo de cáncer de próstata: un diseño «case-only»

“…Individuos expuestos a humo de cigarrillo y que han heredado el genotipo susceptible (GSTM1 o GSTT1 nulo) tendrían incrementada la carga corporal de metabolitos reactivos y, por lo tanto, un mayor riesgo de desarrollar cáncer de próstata 25,38 . En este estudio, en primer lugar examinamos la interacción entre los polimorfismos genéticos GSTM1, GSTT1 y CYP1A1, y posteriormente analizamos la interacción entre éstos y el hábito de fumar, y su asociación con el riesgo de cáncer de próstata.…”

“…En general, no se han reportado asociaciones significativas entre combinaciones de los genotipos susceptibles para GSTM1, GSTT1 y riesgo de CaP 25,31 . Steinhoff y cols, en cambio, reportaron una significativa asociación entre estos polimorfismos y CaP 38 .…”