Gluten and casein supplementation does not increase symptoms in children with autism spectrum disorder

Pusponegoro, Hardiono D.; Ismael, Sofyan; Firmansyah, Agus; Sastroasmoro, Sudigdo; Vandenplas, Yvan

doi:10.1111/apa.13108

Cited by 45 publications

(33 citation statements)

References 20 publications

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“…Subjects on a regular diet were randomized to receive a gluten/casein or placebo supplement for 7 days. Administrating gluten/casein to children with ASD for 1 week did not increase maladaptive behavior, gastrointestinal symptom severity or urinary I-FABP excretion [29] .…”

Section: Gluten Sensitivity and Autismmentioning

confidence: 80%

Gluten Sensitivity

Catassi¹

2015

Ann Nutr Metab

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Non-celiac gluten sensitivity (NCGS) is a syndrome characterized by intestinal and extraintestinal symptoms related to the ingestion of gluten-containing food in subjects who are not affected by either celiac disease (CD) or wheat allergy (WA). The prevalence of NCGS is not clearly defined yet. Indirect evidence suggests that NCGS is slightly more common than CD, the latter affecting around 1% of the general population. NCGS has been mostly described in adults, particularly in females in the age group of 30-50 years; however, pediatric case series have also been reported. Since NCGS may be transient, gluten tolerance needs to be reassessed over time in patients with NCGS. NCGS is characterized by symptoms that usually occur soon after gluten ingestion, disappear with gluten withdrawal, and relapse following gluten challenge within hours/days. The ‘classical' presentation of NCGS is a combination of irritable bowel syndrome-like symptoms, including abdominal pain, bloating, bowel habit abnormalities (either diarrhea or constipation), and systemic manifestations such as ‘foggy mind', headache, fatigue, joint and muscle pain, leg or arm numbness, dermatitis (eczema or skin rash), depression, and anemia. In recent years, several studies explored the relationship between the ingestion of gluten-containing food and the appearance of neurological and psychiatric disorders/symptoms like ataxia, peripheral neuropathy, schizophrenia, autism, depression, anxiety, and hallucinations (so-called gluten psychosis). The diagnosis of NCGS should be considered in patients with persistent intestinal and/or extraintestinal complaints showing a normal result of the CD and WA serological markers on a gluten-containing diet, usually reporting worsening of symptoms after eating gluten-rich food. NCGS should not be an exclusion diagnosis only. Unfortunately, no biomarker is sensitive and specific enough for diagnostic purposes; therefore, the diagnosis of NCGS is currently based on establishing a clear-cut cause-effect relationship between the ingestion of gluten and the appearance of symptoms by a standardized double-blind, placebo-controlled gluten challenge.

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Section: Gluten Sensitivity and Autismmentioning

confidence: 80%

Gluten Sensitivity

Catassi¹

2015

Ann Nutr Metab

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“…The exposure to a gluten-and casein-free diet for a week did neither affect the maladaptive behavior nor the intensity of the gastrointestinal symptoms or the urinary excretion of the fatty acid-binding protein (I-FABP) in autistic children [72] . More long-term studies to evaluate the physiopathological mechanisms of the enterocyte in autistic children are needed.…”

Section: Autism and Special Dietsmentioning

confidence: 97%

Truths, Myths and Needs of Special Diets: Attention-Deficit/Hyperactivity Disorder, Autism, Non-Celiac Gluten Sensitivity, and Vegetarianism

Cruchet

Lucero²,

Cornejo³

2016

Ann Nutr Metab

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Different dietary approaches have been attempted for the treatment of attention-deficit/hyperactivity disorder and autism, but only three of them have been subjected to clinical trials: education in healthy nutritional habits, supplementation and elimination diets. On the other hand, for multiple reasons, the number of people who adopt vegetarian and gluten-free diets (GFD) increases daily. More recently, a new entity, non-celiac gluten sensitivity (NCGS), with a still evolving definition and clinical spectrum, has been described. Although, the benefits of GFD are clearly supported in this condition as well as in celiac disease, in the last two decades, GFD has expanded to a wider population. In this review, we will attempt to clarify, according to the existing evidence, which are the myths and facts of these diets.

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“…These foods, rich in glutamic acid, contribute to atrophy of the villi in the small intestine and have neurotoxicity, which is a hot theme for discussion by Neuro Dietitians [21].…”

Section: Sources and Biological Significance Of Glutamic Acidmentioning

confidence: 99%

“…Перечень продуктов, исключаемых из рациона пациентов с РАС, расширен до большой вредоносной четверки: глютен, казеин, соя и кукуруза. Эти продукты, богатые глутаминовой кислотой, способствуют атрофии ворсинок в тонком кишечнике и обладают нейротоксичностью, что является горячей темой обсуждения нейродиетологов [21].…”

Section: источники и биологическое значение глутаминовой кислотыunclassified

The Pathophysiological Rationale for Personalized Metabolic Therapy of ASD. Promising Treatments

Polyakova

2019

Autism and Developmental Disorders

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A metabolic disorder is a serious problem. Changes that occur at the cellular level and are associated with biochemical processes lead to malfunctioning of the cell, and further, respectively, of tissue, organ, of the whole organism. Metabolic care is the basis of metabolic therapy. For almost every metabolic regimen of autism spectrum disorder, there is a counter-argument. For this reason, a unified approach to therapy is impossible, since, apart from the "autistic triad", each person has his own peculiarities. At the present stage, in addition to a gluten-free and casein-free diet, vitamins of groups B and D, polyunsaturated fatty acids, various methods of microbiome correction are used in therapy, but there is no serious evidence base for the effectiveness of therapy for autism spectrum disorders. The article proposes options for the study of metabolic changes in the body, which are the rationale for the development of a scheme of metabolic therapy in the framework of a personalized medical approach to the treatment of autism spectrum disorders.

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Gluten and casein supplementation does not increase symptoms in children with autism spectrum disorder

Abstract: Administrating gluten-casein to children with ASD for one week did not increase maladaptive behaviour, gastrointestinal symptom severity or urinary I-FABP excretion. The effect of prolonged administration or other mechanisms of enterocyte damage in ASD should be explored.

Cited by 45 publications

References 20 publications

Gluten Sensitivity

Gluten Sensitivity

Truths, Myths and Needs of Special Diets: Attention-Deficit/Hyperactivity Disorder, Autism, Non-Celiac Gluten Sensitivity, and Vegetarianism

The Pathophysiological Rationale for Personalized Metabolic Therapy of ASD. Promising Treatments

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