Gluten, Dysbiosis, and Genetics in Celiac Disease: All Are Important

Waszczuk, Ewa; Waszczuk, Karolina

doi:10.1007/s10620-016-4264-5

Cited by 2 publications

(1 citation statement)

References 7 publications

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“…The relative excess of IBS symptoms among patients with celiac disease could also be attributable to the HLA immunophenotype[23]. In our cohort, IBS symptoms were more frequent and more persistent among individuals who were HLADQ2 − DQ8 + .…”

Section: Discussionmentioning

confidence: 84%

Symptoms of Functional Intestinal Disorders Are Common in Patients with Celiac Disease Following Transition to a Gluten-Free Diet

Silvester

Graff

Rigaux³

et al. 2017

Dig Dis Sci

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Background Celiac disease and functional intestinal disorders may overlap, yet the natural history of functional symptoms in patients with celiac disease is unknown. Aim To investigate the prevalence of irritable bowel syndrome (IBS), functional dyspepsia (FD) and functional bloating (FB) symptoms among patients with celiac disease at diagnosis and during the first year of a gluten-free diet. Methods Adults with a new diagnosis of celiac disease were surveyed at baseline, 6 months and 1 year using standardized measures for intestinal symptoms [Rome III diagnostic questionnaire and Celiac Symptom Index (CSI)] and gluten-free diet adherence [Gluten-Free Eating Assessment Tool (GF-EAT) and Celiac Diet Adherence Test (CDAT)]. Results At diagnosis, two-thirds fulfilled Rome III diagnostic questionnaire symptom criteria for IBS (52%), functional dyspepsia (27%) and/or functional bloating (9%). One year post-diagnosis, there was high adherence to a gluten-free diet as 93% reported gluten exposure less than once per month on the GF-EAT and only 8% had ongoing celiac disease symptoms (CSI score > 45). The rates of those meeting IBS (22%) and functional dyspepsia (8%) symptom criteria both decreased significantly on a gluten-free diet. The prevalence of functional symptoms (any of IBS, FD or FB) at 1 year was 47%. Conclusions Long-term follow-up of patients with celiac disease is necessary because many patients with celiac disease who are adherent to a gluten-free diet have persistent gastrointestinal symptoms.

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Section: Discussionmentioning

confidence: 84%

Symptoms of Functional Intestinal Disorders Are Common in Patients with Celiac Disease Following Transition to a Gluten-Free Diet

Silvester

Graff

Rigaux³

et al. 2017

Dig Dis Sci

View full text Add to dashboard Cite

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Neurological syndromes of celiac disease

Kopishinskaia

Никитин²

2021

Medicinskij alfavit

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Celiac disease is an autoimmune disease in people with a genetic predisposition resulting from the consumption of gluten proteins from wheat, rye, barley and characterized by inflammation of the mucous membrane of the small intestine and atrophy of the villi. Neuropathy, migraine, chronic cerebellar ataxia and fibromyalgia are the most common extraintestinal celiac disease syndromes. The study of small nerve fibers is necessary for painful celiac disease syndromes such as gluten neuropathy and fibromyalgia, as well as for gluten autonomic neuropathy. The study of antineuronal antiganglioside antibodies is necessary for such lesions of both the central and peripheral nervous systems as gluten neuropathy and gluten cerebellar ataxia. A gluten-free diet directly affects the disappearance of headache attacks or a decrease in their frequency and intensity. There is little research on the effect of a gluten-free diet on headache risk.

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Gluten, Dysbiosis, and Genetics in Celiac Disease: All Are Important

Cited by 2 publications

References 7 publications

Symptoms of Functional Intestinal Disorders Are Common in Patients with Celiac Disease Following Transition to a Gluten-Free Diet

Symptoms of Functional Intestinal Disorders Are Common in Patients with Celiac Disease Following Transition to a Gluten-Free Diet

Neurological syndromes of celiac disease

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