Gluten sensitivity: from gut to brain

Hadjivassiliou, Marios; Sanders, David S.; Grünewald, Richard A.; Woodroofe, Nicola; Boscolo, Sabrina; Aeschlimann, Daniel

doi:10.1016/s1474-4422(09)70290-x

Cited by 347 publications

(376 citation statements)

References 127 publications

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“…In this study we wanted to explore the role (if any) of TG6 antibodies in the second commonest neurological manifestation of gluten sensitivity, which is gluten neuropathy [1]. We do not know if TG6 is also present in peripheral nervous tissue, which of course includes the gut neural plexus.…”

Section: Discussionmentioning

confidence: 99%

“…Gluten neuropathy is the second commonest neurological manifestation of gluten sensitivity [1]. It is defined as an otherwise idiopathic peripheral neuropathy associated with serological markers of gluten sensitivity (one or more of antigliadin IgG and/or IgA, endomysial and transglutaminase-2 antibodies) [2].…”

Section: Introductionmentioning

confidence: 99%

“…It is defined as an otherwise idiopathic peripheral neuropathy associated with serological markers of gluten sensitivity (one or more of antigliadin IgG and/or IgA, endomysial and transglutaminase-2 antibodies) [2]. The commonest type of gluten neuropathy is symmetrical sensorimotor axonal peripheral neuropathy [1]. Sensory ganglionopathy, an asymmetrical pure sensory neuropathy is the second commonest form of neuropathy seen in the context of gluten sensitivity [3].…”

Section: Introductionmentioning

confidence: 99%

“…Like TG2 in Coeliac Disease (CD) and TG3 in dermatitis herpetiformis, TG6 is likely to be the autoantigen in gluten related diseases where the primary manifestation is neurological [1]. TG2, TG3 and TG6 share 65% homology, they are capable of deamidating gluten peptides and antibodies against TG2, TG3 and TG6 are eliminated with strict adherence to a gluten-free diet [10].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Transglutaminase 6 antibodies in gluten neuropathy

Zis

Rao

Sarrigiannis

et al. 2017

Digestive and Liver Disease

Self Cite

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Transglutaminase 6 antibodies in gluten neuropathy

Zis

Rao

Sarrigiannis

et al. 2017

Digestive and Liver Disease

Self Cite

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“…1, 2 The prevalence of CD in the Western world has been increasing steadily, and it is now recognized as a common disorder. 3 Its incidence has increased due to recognition of atypical CD forms 4 and the identification of silent cases. 5 The increased ability to identify silent cases along with classical celiac patients is mainly attributable to the increasing number of serological tests available, providing noninvasive tools along with improved performance.…”

Section: Introductionmentioning

confidence: 99%

A new algorithm for the diagnosis of celiac disease

et al. 2011

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Celiac disease (CD) affects at least 1% of the Western population but remains largely unrecognized. In our laboratory, we utilize a novel algorithm to diagnose pediatric CD that offers both high sensitivity and high specificity for diagnosis in an outpatient setting. The aim of the present study was to challenge this algorithm and to test its performance in children and adults suspected of having CD. Using a three-assay algorithm, screening with the most sensitive tissue transglutaminase (tTG) complexed with deamidated gliadin peptide neoepitope immunoglobulin A (IgA)1IgG assay and confirming with the two specific tTG IgA and tTG IgA1IgG assays, we examined the serological results from 112 children aged 0-17 years old and 60 adults in comparison to their respective biopsy results. The algorithm performance was calculated by statistical analysis. The use of the new algorithm enabled us to diagnose CD with 98% sensitivity, 93% specificity and 95% accuracy in the pediatric group and 94% sensitivity, 92% specificity and 93% accuracy in the total population studied. The false-negative cases in the adult group were attributed to previous adherence to a gluten-free diet, and the single false-negative result in a young child became a true positive after 6 months. We have also monitored three celiac patients before and after diagnosis and found that the algorithm may be suitable for disease monitoring. The newly proposed three-assay algorithm for celiac detection is very reliable in both children and adults. Due to the high performance of this assay, the further need for confirmatory intestinal biopsies will be reassessed.

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Celiac Disease Diagnosis and Management

Leffler¹

2011

JAMA

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Celiac disease is one of the most prevalent autoimmune gastrointestinal disorders but as the case of Ms. J illustrates, diagnosis is often delayed or missed. Based on serology studies, the prevalence of celiac disease in many populations is estimated to be approximately 1% and has been increasing steadily over the last 50 years. Evaluation for celiac disease is generally straightforward, and uses commonly available serologic tests, however the signs and symptoms of celiac disease are nonspecific and highly heterogeneous making diagnosis difficult. While celiac disease is often considered a mild disorder treatable with simple dietary changes, in reality celiac disease imparts considerable risks including reduced bone mineral density, impaired quality of life, and increased overall mortality. In addition, the gluten free diet is highly burdensome and can profoundly affect patients and their families. For these reasons, care of individuals with celiac disease requires prompt diagnosis and ongoing multidisciplinary management.

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Gluten sensitivity: from gut to brain

Cited by 347 publications

References 127 publications

Transglutaminase 6 antibodies in gluten neuropathy

Transglutaminase 6 antibodies in gluten neuropathy

A new algorithm for the diagnosis of celiac disease

Celiac Disease Diagnosis and Management

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