Gly-Val-Arg, an angiotensin-I-converting enzyme inhibitory tripeptide ameliorates hypertension on spontaneously hypertensive rats

Antihypertensive effect and underlying mechanism of tripeptide NCW on spontaneously hypertensive rats using metabolomics analysis

“…A similar view was expressed by Manoharan et al, and a differential level of bile acid metabolites was observed in SHRs after GVR treatment. 15 The present findings proposed that the antihypertensive activity of NCW may be explained by improving the endothelial dysfunction and the disturbances in 11β-HSD2.…”

“…Moreover, the metabolomics analysis carried out by Manoharan et al found the level change of creatine, glycocholic acid, hypoxanthine, kynurenine, niacinamide, phenylpyruvic acid, phytosphingosine, pyrroline hydroxycarboxylic acid, sphinganine, taurocholic acid, and uric acid in the sera of SHRs treated with tripeptide GVR, which demonstrated that tripeptide GVR may lower BP by influencing the renin-angiotensin system. 15 Additionally, nontargeted serum metabolomics was used to explore the mechanisms involved in BP regulation of the peptide RVPSL. 16 It is interesting to note that peptides with a strong in vitro ACE inhibitory activity do not necessarily have the corresponding in vivo antihypertensive effect.…”

In vivo anti‐hypertensive effect of peptides from egg white and its molecular mechanism with ACE

“…Liu et al indicated that the YLVR (10 mg kg −1 bw) could reduce SBP values by 27.31 mmHg in SHRs at the third week (Liu et al ., 2018). After intragastric administration of GVR (100 mg kg −1 bw) for long‐term, the SBP in SHRs was significantly reduced by 30 mmHg (Manoharan et al ., 2018). In addition, in our study the SBP values of QIGLF and RVPSL decreased around 43 mmHg.…”

“…Miguel et al indicated that the egg white hydrolysate with pepsin (HEW) significantly reduced the SBP (Miguel et al, 2006;Miguel et al, 2007a). And ACE inhibitory peptides from food proteins are stable and associated with less side effects (Wu et al, 2017;Manoharan et al, 2018).…”

Rapeseed protein-derived peptides, LY, RALP, and GHS, modulates key enzymes and intermediate products of renin–angiotensin system pathway in spontaneously hypertensive rat

“…16 Recently a long-term study was carried out where the tripeptide GVR was orally administered to SHRs with 50 and 100 mg/kg bw for 21 days and the SBP reduction was observed significantly by 23 and 30 mm Hg, respectively. 26 Although the SBP-lowering effects of the rapeseed peptides were lower than that of captopril, their putative safety, as naturally derived compounds, makes them attractive for further evaluation as physiologically active agents for preventing hypertension.…”