GlycA, a novel proinflammatory glycoprotein biomarker, and high-sensitivity C-reactive protein are inversely associated with sodium intake after controlling for adiposity: the Prevention of Renal and Vascular End-Stage Disease study

Abstract

The proinflammatory biomarkers GlycA and hsCRP are inversely related to higher 24-h sodium excretion when taking into account the variation in adiposity. These inverse relations remain present after taking into account other covariates.

Research update for articles published in EJCI in 2015

“…GlycA comprehensively reflects the glycosylation state and plasma concentrations of a number of abundant acutephase proteins [4,5]. Our finding that GlycA levels are higher in subjects with metabolic syndrome [4] has been reinforced in a number of studies, also showing that GlycA correlates positively with obesity measures [5][6][7][8]. Interestingly, GlycA has now been demonstrated to predict incident cardiovascular disease, as well as type 2 diabetes mellitus in several population-based cohorts, and this association is at least as strong as that with C-reactive protein [5].…”

Primary aldosteronism is associated with decreased low‐density and high‐density lipoprotein particle concentrations and increased GlycA, a pro‐inflammatory glycoprotein biomarker

“…35 Venous blood samples were obtained at the beginning of an adrenal venous sampling (AVS) procedure for subtype classification. 28,31,32,37 In short, after exclusion of subjects with insulin-treated diabetes and pregnant women, all subjects with a urinary albumin concentration ≥10 mg/L were invited to participate (n = 7768), of whom 6000 accepted. The PA group originally consisted of 12 men and 11 women.…”

“…28,31,32 All participants were instructed to let venous blood being drawn after an overnight fast. Smoking status was categorized as current (yes/no).…”

“…Details of the study have been described elsewhere. 28,31,32,37 In short, after exclusion of subjects with insulin-treated diabetes and pregnant women, all subjects with a urinary albumin concentration ≥10 mg/L were invited to participate (n = 7768), of whom 6000 accepted. In addition, a random sample of 2592 individuals with a urinary albumin concentration <10 mg/L was included.…”

“…Information on self-reported medication was combined with information from a pharmacy-dispensing registry, which has complete information on drug usage/consumption of >95% of subjects participating in PREVEND. 28,31,32 All participants were instructed to let venous blood being drawn after an overnight fast. Blood samples were taken after 15 minutes rest.…”