Glycaemic variability is associated with adverse cardiovascular outcomes in patients hospitalised with an acute myocardial infarction

Chai, Thora Y; McLean, Mark; Wong, Vincent W.; Cheung, N. Wah

doi:10.1016/j.jcte.2019.100203

Cited by 5 publications

(8 citation statements)

References 17 publications

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“…The final analysis included 11 studies which met the inclusion criteria for meta-analysis. [15][16][17][18][19][20][21][22][23][24][25]…”

Section: Results Of Literature Searchmentioning

confidence: 99%

“…The characteristics of the included studies were showed in Table 1. Overall, 11 prospective studies with 3709 ACS patients were included in this meta-analysis, of which six studies included patients with acute myocardial infarction, [15][16][17][18][19]24 five included patients with ACS. [20][21][22][23]25 The studies were all performed in China, Japan, Australia and France, with sample sizes varying from 34 to 864.…”

Section: Study Characteristics and Quality Evaluationmentioning

confidence: 99%

“…A total of eight prospective datasets [15][16][17][18][19]21,22,24 reported the association between MAGE and incidence of adverse cardiovascular events in ACS patients. There was no significant heterogeneity among studies (I 2 = 19%, p for Cochrane's Q test = 0.26).…”

Section: Association Between Mage and Prognosis In Acs Patientsmentioning

confidence: 99%

“…In addition, GV has been hypothesized to be deleterious in ACS patients. [15][16][17][18][19][20][21][22][23][24][25] However, Lipska et al 26 demonstrated that GV did not provide additional value after controlling the multiple risk factors in patients with ACS. Meanwhile, a recent meta-analysis with 7 studies showed that 4 eligible studies revealed an association between myocardial infarction and GV, while others did not.…”

Section: Introductionmentioning

confidence: 99%

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Glycaemic variability and risk of adverse cardiovascular events in acute coronary syndrome

Zhang

Liu

et al. 2022

Diabetes and Vascular Disease Research

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Objective The relationship between different glycaemic variability (GV) indexes and adverse cardiovascular outcomes is not well understood. This study aims to determine whether GV is related to the occurrence of adverse cardiovascular events in patients with acute coronary syndrome (ACS). Methods PubMed, EMBASE, and Web of Science were comprehensively searched from the establishment of databases to 29 June 2022. The relationship between two important GV indexes, including the mean amplitude of glycemic excursion (MAGE) and standard deviation (SD), and the adverse cardiovascular events in ACS patients were evaluated, respectively. Results A total of 11 studies with 3709 ACS patients were included. Pooled results showed that patients with higher GV had significantly increased risk of adverse cardiovascular events, including MAGE (relative risk [RR] = 1.76, 95% CI: 1.40 to 2.22, p < 0.001, I2 = 25%) and SD (RR = 2.14, 95% CI: 1.73 to 2.66, p < 0.001, I2 = 0%). Conclusions Increased GV is related to the poor prognosis in patients with ACS. Additionally, more well-designed studies comparing different indicators of GV with adverse cardiovascular events in ACS patients are still warranted.

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“…The final analysis included 11 studies which met the inclusion criteria for meta-analysis. [15][16][17][18][19][20][21][22][23][24][25]…”

Section: Results Of Literature Searchmentioning

confidence: 99%

Section: Study Characteristics and Quality Evaluationmentioning

confidence: 99%

Section: Association Between Mage and Prognosis In Acs Patientsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Glycaemic variability and risk of adverse cardiovascular events in acute coronary syndrome

Zhang

Liu

et al. 2022

Diabetes and Vascular Disease Research

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“…Cardiovascular complications are the main cause of death in diabetic patients [ 7 , 8 ]. Previous studies showed that admission hyperglycemia was an independent risk factor for poor prognosis of ACS patients, irrespective of whether or not they had diabetes [ 9 , 10 ]. Pasquale first showed that hyperglycemia was associated with adverse outcomes and increased risk of restenosis in ST-elevation myocardial infarction patients without diabetes mellitus [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Admission Hyperglycemia on Short-Term Prognosis of Patients with Non-ST Elevation Acute Coronary Syndrome without Diabetes Mellitus

Liu

Xing

et al. 2021

Journal of Diabetes Research

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Objective. To evaluate the effect of admission hyperglycemia on the short-term prognosis of patients with non-ST elevation acute coronary syndrome (NSTE-ACS) without diabetes mellitus. Methods. The clinical data of 498 patients with NSTE-ACS admitted to the Department of Cardiology of the First Affiliated Hospital of Henan University of Science and Technology between March 2018 and November 2020 were analyzed. Based on the blood glucose (BG) level at admission, patients were divided into three groups: A ( BG < 7.8 mmol/L), B ( 7.8 mmol / L ≤ BG < 11.1 mmol / L ), and C ( BG ≥ 11.1 mmol/L). The clinical data of the three groups were compared. Results. There was no significant difference between the three groups in terms of age, sex, hypertension, hyperlipidemia, smoking, and history of myocardial infarction ( p > 0.05 ). However, there were significant differences in the incidences of multivessel disease, renal insufficiency, pump failure, and emergency percutaneous coronary intervention, and levels of high-sensitivity C-reactive protein, cardiac troponin T, and creatine kinase isoenzyme MB among the three groups ( p < 0.05 for all). The incidences of severe pump failure, malignant arrhythmias, and death were significantly higher in groups B and C compared to group A ( p < 0.05 ). Additionally, the incidences of severe pump failure, malignant arrhythmias, and death were significantly higher in group C compared to group B ( p < 0.05 ). Multivariate logistic regression analysis showed that hyperglycemia, renal insufficiency, Killip grade III/IV, and age were risk factors of in-hospital death. Conclusion. Hyperglycemia at admission is a risk factor for adverse in-hospital clinical outcomes in patients with NSTE-ACS.

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The effect of stress hyperglycemıa seen ın acute ST-segment elevatıon ın myocardıal ınfarctıon on ın-hospıtal mortalıty

2022

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Glycaemic variability is associated with adverse cardiovascular outcomes in patients hospitalised with an acute myocardial infarction

Cited by 5 publications

References 17 publications

Glycaemic variability and risk of adverse cardiovascular events in acute coronary syndrome

Glycaemic variability and risk of adverse cardiovascular events in acute coronary syndrome

Effect of Admission Hyperglycemia on Short-Term Prognosis of Patients with Non-ST Elevation Acute Coronary Syndrome without Diabetes Mellitus

The effect of stress hyperglycemıa seen ın acute ST-segment elevatıon ın myocardıal ınfarctıon on ın-hospıtal mortalıty

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