2015
DOI: 10.1016/j.jaci.2014.10.057
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Glycans and glycan-binding proteins in immune regulation: A concise introduction to glycobiology for the allergist

Abstract: Cells are endowed with a rich surface coat of glycans carried as glycoproteins and glycolipids on the outer leaflet of their plasma membranes and constituting a major molecular interface between cells and their environment. Each cell’s glycome, the sum of its diverse glycan structures, comprises a distinct cellular signature that is defined by the expression levels of the enzymes responsible for glycan biosynthesis. This signature can be read by complementary glycan binding proteins that translate glycan recog… Show more

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Cited by 91 publications
(91 citation statements)
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“…The glycoprotein and glycolipid content of immune or inflammatory cells as well as their targets will modulate response and lectins such as Galectin 3 are critical in these processes (123,124). Galectin 3 has a broad range of effects on T cells, NK cells, macrophages, neutrophils, and other immune cells (125)(126)(127)(128)(129)(130)(131)(132)(133)(134).…”
Section: Galectin 3 Regulation Of Immune Surveillancementioning
confidence: 99%
See 1 more Smart Citation
“…The glycoprotein and glycolipid content of immune or inflammatory cells as well as their targets will modulate response and lectins such as Galectin 3 are critical in these processes (123,124). Galectin 3 has a broad range of effects on T cells, NK cells, macrophages, neutrophils, and other immune cells (125)(126)(127)(128)(129)(130)(131)(132)(133)(134).…”
Section: Galectin 3 Regulation Of Immune Surveillancementioning
confidence: 99%
“…The effect of Galectin 3 on CD45 is dependent on the type of glycans present; while Galectin 3 binds Nglycans on CD45 interaction with O-glycans is required for apoptotic induction (126). Galectin 3 is a key player in modulating the adaptive immune response of T cells by regulating T cell receptor (TCR) activation (123,125,(130)(131)(132). The TCR is glycosylated by MGAT5 in the Golgi which promotes binding to Galectin 3 resulting in reduced activation of the receptor (125,130).…”
Section: Galectin 3 Regulation Of Immune Surveillancementioning
confidence: 99%
“…The resulting “glycoproteins” or “glycolipids” contain abundant carbohydrates on the extracellular side of the cell membranes and play integral roles in cell–cell and cell–matrix interactions by regulating cell adhesion, cell trafficking, and signal transduction 1, 2, 3. Abnormal glycosylation is associated with severe diseases, including tumorigenesis, malignant differentiation, and cancer metastasis and development 4, 5, 6…”
Section: Introductionmentioning
confidence: 99%
“…Sialic acids are diverse, varying in structure and expression level in different cells and tissues and in response to stresses and genetic factors. 6 Several viruses and bacteria secrete sialidases that cleave sialic acids from host cell surfaces. 7 By so limiting the protective properties of factor H, these sialic acid-modifying pathogens may "tip the balance," triggering onset of symptomatic disease in aHUS caused by any mutation (not just factor H), as well as in diarrhea-associated HUS caused by enteropathogenic Escherichia coli or in HUS caused by the neuraminidase-secreting Streptococcus pneumoniae.…”
mentioning
confidence: 99%