Glycated albumin as an improved indicator of glycemic control in hemodialysis patients with type 2 diabetes based on fasting plasma glucose and oral glucose tolerance test

Nagayama, Harumi; Inaba, Masaaki; Okabe, Reiko; Emoto, Masanori; Ishimura, Eiji; Okazaki, Shuji; Nishizawà, Yoshiki

doi:10.1016/j.biopha.2008.04.002

Cited by 57 publications

(42 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These include circumstances that involve factors that interfere with the actual measurement of Hb A 1c , such as certain hemoglobin variants or adducts (30 -34 ), as well as factors that affect the interpretation of Hb A 1c results. The latter includes severe iron-deficiency anemia or any condition that alters the erythrocyte lifespan (e.g., hemolytic anemia, renal failure) (35)(36)(37)(38)(39). Additional factors, such as race and age, have also been reported to influence Hb A 1c .…”

Section: Interferences With Hb a 1c Testingmentioning

confidence: 99%

Status of Hemoglobin A1c Measurement and Goals for Improvement: From Chaos to Order for Improving Diabetes Care

2011

View full text Add to dashboard Cite

BACKGROUND:The Diabetes Control and Complications Trial (DCCT) and United Kingdom Prospective Diabetes Study (UKPDS) established the importance of hemoglobin A 1c (Hb A 1c ) as a predictor of outcome in patients with diabetes mellitus. In 1994, the American Diabetes Association began recommending specific Hb A 1c targets, but lack of comparability among assays limited the ability of clinicians to use these targets. The National Glycohemoglobin Standardization Program (NGSP) was implemented in 1996 to standardize Hb A 1c results to those of the DCCT/UKPDS. CONTENT:The NGSP certifies manufacturers of Hb A 1c methods as traceable to the DCCT. The certification criteria have been tightened over time and the NGSP has worked with the College of American Pathologists in tightening proficiency-testing requirements. As a result, variability of Hb A 1c results among clinical laboratories has been considerably reduced. The IFCC has developed a reference system for Hb A 1c that facilitates metrological traceability to a higher order. The NGSP maintains traceability to the IFCC network via ongoing sample comparisons. There has been controversy over whether to report Hb A 1c results in IFCC or NGSP units, or as estimated average glucose. Individual countries are making this decision.

show abstract

Section: Interferences With Hb a 1c Testingmentioning

confidence: 99%

Status of Hemoglobin A1c Measurement and Goals for Improvement: From Chaos to Order for Improving Diabetes Care

2011

View full text Add to dashboard Cite

show abstract

“…The aetiology of oxidative stress in diabetes arises from a variety of mechanisms such as excessive oxygen radical production from auto-oxidation of glucose, [61] glycated proteins and glycation of anti-oxidative enzymes, which limit their capacity to detoxify oxygen radicals [20]. In addition to these mechanisms, two others have been suggested as being responsible for the generation of oxygen radicals in diabetes.…”

Section: Oxygen Free Radical In Diabetesmentioning

confidence: 99%

“…In such cases, glycated albumin appears to be an alternative marker for glycaemic control: the glycated albumin level is thought to indicate blood glucose status over a short period (2 to 4 weeks), while HbA1c reflects the glycaemic state over a longer period (2 months). Indeed, numerous studies support the use of glycated albumin levels in the detection of short-term changes in glycaemic control [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Role of Human Serum Albumin and Oxidative Stress in Diabetes

Prakash

2017

JABB

View full text Add to dashboard Cite

DiabetesDiabetes mellitus (DM) comprises a group of common metabolic disorders that share the phenotype of hyperglycemia. Several distinct types of DM exist and are caused by a complex interaction of genetics, environmental factors and life-style AbstractChanges in human behaviour and lifestyle over the last century have resulted in a dramatic increase in the incidence of diabetes worldwide. Albumin, a major protein in the blood circulation, can undergo increased glycation in diabetes. From recent studies, it has become evident that glycation has important implications for albumin actions and impact on cell functioning. Human serum albumin (HSA) is the most abundant serum protein whose redox modifications modulate its physiological function, as well as serves as bio-marker for oxidative stress. Previous experimental and clinical studies report that oxidative stress plays a major role in the pathogenesis and development of complications of both types of DM. Hypoalbuminemia is the strongest clinical indicator of progression of many human diseases including cancer, diabetes, rheumatic diseases, liver and other diseases. Also, there is currently great interest in the potential contribution of increased oxidative stress to the development of complications in diabetes mellitus. This mini review highlights the association of human serum albumin and oxidative stress in diabetes.

show abstract

“…One study used a single-day sevensample glucose profile set [1], which was the reference method used in the Diabetes Control and Complications Trial. In another study the authors compared HbA1c with plasma glucose levels during a 75 g oral glucose tolerance test [8]. However, because of their metabolic turnover rates, HbA1c and GA reflect glycemic status over two to three months and four to six weeks respectively.…”

Section: Brief Communication (Original)mentioning

confidence: 99%

Brief communication (Original). Correlation of glycated albumin with self blood glucose monitoring in diabetic patients on hemodialysis taking erythropoietin

2014

View full text Add to dashboard Cite

Background: Serum glycated albumin (GA) is a marker of glycemic control in diabetic renal patients, but studies were limited by the use of few random glucose values to define glycemic control. Objectives: To determine whether GA correlated with self blood glucose monitoring is better than HbA1c in hemodialyzed diabetic patients taking erythropoietin. Methods: This was a cross-sectional study of diabetic patients on hemodialysis with and without erythropoietin. GA was measured by ELISA and HbA1c by ion-exchange HPLC. GA was reported as the GA/albumin ratio where albumin was measured using bromocresol green. The average capillary blood glucose level over the preceding three months (CBG) was calculated from self-reported daily prebreakfast, prelunch, and prebed glucose meter readings. Results: Thirty-four patients were recruited; 18 were taking erythropoietin (6000 units per week) and 16 had never received erythropoietin. HbA1c correlated poorly with CBG in patients taking erythropoietin (r = -0.014, P = 0.96) compared with patients without erythropoietin (r = 0.579, P = 0.02). The correlation of GA/albumin ratio with CBG in the erythropoietin group (r = 0.612, P = 0.007) was similar to the nonerythropoietin group (r = 0.854, P < 0.001). The slope for HbA1c versus CBG was 2.8-fold greater in patients without erythropoietin compared with those taking erythropoietin. There was no significant difference in the slopes for GA/albumin ratio versus CBG between the two patient groups (P > 0.05). Conclusion:In diabetic patients on hemodialysis and taking low doses of erythropoietin, GA/albumin is a better marker of glycemic control than HbA1c.

show abstract

Glycated albumin as an improved indicator of glycemic control in hemodialysis patients with type 2 diabetes based on fasting plasma glucose and oral glucose tolerance test

Cited by 57 publications

References 13 publications

Status of Hemoglobin A1c Measurement and Goals for Improvement: From Chaos to Order for Improving Diabetes Care

Status of Hemoglobin A1c Measurement and Goals for Improvement: From Chaos to Order for Improving Diabetes Care

Role of Human Serum Albumin and Oxidative Stress in Diabetes

Brief communication (Original). Correlation of glycated albumin with self blood glucose monitoring in diabetic patients on hemodialysis taking erythropoietin

Contact Info

Product

Resources

About