Glycated Albumin is Independently Associated With Arterial Stiffness in Non-Diabetic Chronic Kidney Disease Patients

Choi, Hoon Young; Park, Seung Kyo; Yun, Gi Young; Choi, Ah Ran; Lee, Jung Eun; Ha, Sung Kyu; Park, Hyeong Cheon

doi:10.1097/md.0000000000003362

Cited by 10 publications

(7 citation statements)

References 38 publications

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“…A role of oxidative stress in the occurrence of arteriosclerosis and arterial stiffness in CKD has also been reported [164]. Several uremic toxins such as AGEs, IS, and p-cresyl sulfate and eNOS uncoupling have been shown to induce arterial stiffness through increased oxidative stress [165][166][167][168][169]. In a small study, supplementation of Larginine was shown to be a safe, well-tolerated, and effective way of improving endothelial dysfunction in patients with CKD [169].…”

Section: Arteriosclerosis Arterial Stiffness and Left Ventricular Hmentioning

confidence: 95%

Oxidative stress in chronic kidney disease

et al. 2018

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Oxidative stress (OS), defined as disturbances in the pro-/antioxidant balance, is harmful to cells due to the excessive generation of highly reactive oxygen (ROS) and nitrogen (RNS) species. When the balance is not disturbed, OS has a role in physiological adaptations and signal transduction. However, an excessive amount of ROS and RNS results in the oxidation of biological molecules such as lipids, proteins, and DNA. Oxidative stress has been reported in kidney disease, due to both antioxidant depletions as well as increased ROS production. The kidney is a highly metabolic organ, rich in oxidation reactions in mitochondria, which makes it vulnerable to damage caused by OS, and several studies have shown that OS can accelerate kidney disease progression. Also, in patients at advanced stages of chronic kidney disease (CKD), increased OS is associated with complications such as hypertension, atherosclerosis, inflammation, and anemia. In this review, we aim to describe OS and its influence on CKD progression and its complications. We also discuss the potential role of various antioxidants and pharmacological agents, which may represent potential therapeutic targets to reduce OS in both pediatric and adult CKD patients.

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Section: Arteriosclerosis Arterial Stiffness and Left Ventricular Hmentioning

confidence: 95%

Oxidative stress in chronic kidney disease

et al. 2018

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“…64 In particular, uremic toxins have been shown to induce arterial stiffness through increased oxidative stress. [65][66][67] Elevated levels of ROS are known to lead to cerebral sympathoexcitation in CKD. 68 Further, indoxyl sulfate and p-cresyl phosphate also activate leukocyte adhesion and cerebral endothelial dysfunction.…”

Section: Oxidative Stress and Inflammation In Ckdmentioning

confidence: 99%

Chronic kidney disease in the pathogenesis of acute ischemic stroke

Chelluboina

Vemuganti

2019

J Cereb Blood Flow Metab

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Chronic kidney disease has a graded and independent inverse impact on cerebrovascular health. Both thrombotic and hemorrhagic complications are highly prevalent in chronic kidney disease patients. Growing evidence suggests that in chronic kidney disease patients, ischemic strokes are more common than hemorrhagic strokes. Chronic kidney disease is asymptomatic until an advanced stage, but mild to moderate chronic kidney disease incites various pathogenic mechanisms such as inflammation, oxidative stress, neurohormonal imbalance, formation of uremic toxins and vascular calcification which damage the endothelium and blood vessels. Cognitive dysfunction, dementia, transient infarcts, and white matter lesions are widespread in mild to moderate chronic kidney disease patients. Uremic toxins produced after chronic kidney disease can pass through the blood–brain barrier and mediate cognitive dysfunction and neurodegeneration. Furthermore, chronic kidney disease precipitates vascular risk factors that can lead to atherosclerosis, hypertension, atrial fibrillation, and diabetes. Chronic kidney disease also exacerbates stroke pathogenesis, worsens recovery outcomes, and limits the eligibility of stroke patients to receive available stroke therapeutics. This review highlights the mechanisms involved in the advancement of chronic kidney disease and its possible association with stroke.

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“…Previous studies reported the positive relationships between glycemic markers including fast plasma glucose (FPG), glycated hemoglobin (HbAlc) and glycated albumin (GA), and arterial stiffness in the patients suffered from diabetes and chronic kidney diseases. 3,4 To date, most studies reported the relationships between single glycemic marker and arterial stiffness, but few studies compared the predictive abilities of these three glycemic markers for arterial stiffness. 5,6 Here, the associations of FPG, HbAlc and GA levels with baPWV in the Chinese population stratified by diabetes status were assessed, to identify which glycemic marker is more useful for early screening of atherosclerosis.…”

Section: Introductionmentioning

confidence: 99%

<p>Comparison of Hemoglobin Alc, Glycated Albumin and Fasting Plasma Glucose for Prediction of Arterial Stiffness in Chinese Adults</p>

Wen

Yang

2020

DMSO

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Although diabetes is closely related to cardiovascular disease, there are some disputes whether diabetes can promote arterial stiffness. Therefore, the objective of this study is to compare the predictive abilities of related-glycemic markers including fast plasma glucose (FPG), glycated hemoglobin (HbAlc) and glycated albumin (GA) for the arterial stiffness. Methods: In the present study, 3640 subjects (2171 men, 1469 women) were enrolled, and anthropometrics, brachial ankle pulse wave velocity (baPWV) and other laboratory data were obtained. Spearman correlation and multivariate logistic regression analyses were used to evaluate the relationships between FPG, HbAlc, GA and baPWV. Results: Age, BMI, blood pressure, blood lipids, γ-Glutamyl transpeptidase, uric acid, hypersensitive C-reactive protein, baPWV, FPG, HbAlc, GA, estimated glomerular filtration rate and the incidences of diabetes and hypertension in high baPWV group were much greater than those in control group. Moreover, these above three glycemic markers were positively related to baPWV, and the correlation coefficient of HbAlc was the highest. After adjusting the above factors, HbAlc and FPG, but not GA, were still positively associated with baPWV regardless of diabetes status. Conclusion: Our data demonstrated that, regardless of diabetes status, HbAlc and FPG were superior to GA for predicting arterial stiffness and HbAlc had the highest correlation with arterial stiffness, revealing that HbAlc may be regarded as an early diagnosis marker for atherosclerosis.

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Glycated Albumin is Independently Associated With Arterial Stiffness in Non-Diabetic Chronic Kidney Disease Patients

Abstract: Supplemental Digital Content is available in the text

Cited by 10 publications

References 38 publications

Oxidative stress in chronic kidney disease

Oxidative stress in chronic kidney disease

Chronic kidney disease in the pathogenesis of acute ischemic stroke

<p>Comparison of Hemoglobin Alc, Glycated Albumin and Fasting Plasma Glucose for Prediction of Arterial Stiffness in Chinese Adults</p>

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