Glycated fish protein supplementation modulated gut microbiota composition and reduced inflammation but increased accumulation of advanced glycation end products in high-fat diet fed rats

Mao, Zhenjie; Ren, Yanmei; Zhang, Qi; Dong, Shiyuan; Han, Kaining; Feng, Guangxin; Wu, Haohao; Zhao, Yuanhui

doi:10.1039/c9fo00599d

Cited by 27 publications

(20 citation statements)

References 43 publications

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“…Indeed, the food intake is comparable between WT and LKO as described in our previous publication [ 11 ], and thus the changes in fecal metabolites could be largely explained by gut microbial alterations, instead of food intake. LKO mice have significantly lower levels of fecal SCFAs than WT mice after a short-term HFD feeding, which could be explained by a reduction in SCFA-producing bacteria such as Rikenellaceae [ 33 ] and Ruminococcus_1 [ 41 ]. Our Spearman’s correlation analyses indicate that the fecal levels of all three SCFAs are negatively associated with body weight, supporting the conclusion that decreased abundance of SCFA-producing bacteria potentially contributes in part to the metabolic phenotype of LKO mice.…”

Section: Discussionmentioning

confidence: 99%

“…From our correlation analyses, the expansion of Dubosiella and Angelakisella has a positive correlation with body weight but a negative correlation with fecal SCFAs, suggesting that these bacteria have a novel role in obesity-related microbial dysbiosis. Moreover, Lcn2 deficiency inhibits the growth of SCFA-producing bacteria such as Rikenellaceae [ 33 ] and Ruminococcus_1 [ 41 ]. All of the above-mentioned changes in gut microbiota could be linked to the decreased levels of fecal SCFAs in LKO mice and explain part of the mechanisms for the metabolic phenotype of LKO mice.…”

Section: Discussionmentioning

confidence: 99%

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Identification of gut microbiota and microbial metabolites regulated by an antimicrobial peptide lipocalin 2 in high fat diet-induced obesity

et al. 2020

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Lipocalin 2 (Lcn2), as an anti-microbial peptide is expressed in intestine, and the upregulation of intestinal Lcn2 has been linked to inflammatory bowel disease. However, the role of Lcn2 in shaping gut microbiota during diet-induced obesity (DIO) remains unknown. We found that short-term high fat diet (HFD) feeding strongly stimulates intestinal Lcn2 expression and secretion into the gut lumen. As the HFD feeding prolongs, fecal Lcn2 levels turn to decrease. Lcn2 deficiency accelerates the development of HFD-induced intestinal inflammation and microbiota dysbiosis. Moreover, Lcn2 deficiency leads to the remodeling of microbiota-derived metabolome, including decreased production of short-chain fatty acids (SCFAs) and SCFA-producing microbes. Most importantly, we have identified Lcn2-targeted bacteria and microbiota-derived metabolites that potentially play roles in DIO and metabolic dysregulation. Correlation analyses suggest that Lcn2-targeted Dubosiella and Angelakisella have a novel role in regulating SCFAs production and obesity. Our results provide a novel mechanism involving Lcn2 as an anti-microbial host factor in the control of gut microbiota symbiosis during DIO.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Identification of gut microbiota and microbial metabolites regulated by an antimicrobial peptide lipocalin 2 in high fat diet-induced obesity

et al. 2020

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“…Further metabolomic analysis revealed alterations in pathways related with carbohydrate and amino acid metabolism (Qu et al., 2018). By contrast, when high‐fat diet‐fed rats were exposed to a highly glycated fish protein, diminished populations of the genera Helicobacter and Lachnospiraceae_NK4A136_group were noticed (Mao et al., 2019). With respect to human observations, information on the dAGEs‐microbe interaction is limited.…”

Section: Health Implications Of Dages: Perspectives To Fill the Gap Bmentioning

confidence: 99%

Dietary advanced glycation end‐products: Perspectives linking food processing with health implications

Zhang

2020

Comp Rev Food Sci Food Safe

144

116

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Dietary advanced glycation end products (dAGEs) are complex and heterogeneous compounds derived from nonenzymatic glycation reactions during industrial processing and home cooking. There is mounting evidence showing that dAGEs are closely associated with various chronic diseases, where the absorbed dAGEs fuel the biological AGEs pool to exhibit noxious effects on human health. Currently, due to the uncertain bioavailability and rapid renal clearance of dAGEs, the relationship between dAGEs and biological AGEs remains debatable. In this review, we provide the most updated information on dAGEs including their generation in processed foods, analytical and characterization techniques, metabolic fates, interaction with AGE receptors, implications on human health and reducing strategies. Available evidence demonstrating a relevance between dAGEs and food allergy is also included. AGEs are ubiquitous in foods and their contents largely depend on the reactivity of carbonyl and amino groups, along with surrounding condition mainly pH and heating procedures. Once being digested and absorbed into the circulation, two separate pathways can be involved in the deleterious effects of dAGEs: an AGE receptor‐dependent way to stimulate cell signals, and an AGE receptor‐independent way to dysregulate proteins via forming complexes. Inhibition of AGEs formation during food processing and reduction in the diet are two potent approaches to restrict health‐hazardous dAGEs. To elucidate the biological role of dAGEs toward human health, the following significant perspectives are raised: molecular size and complexity of dAGEs; interactions between unabsorbed dAGEs and gut microbiota; and roles played by concomitant compounds in the heat‐processed foods.

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“…This may be related to the Maillard reaction of proteins in the formation of preserved egg. It was also reported that the intake of glycated fish protein could reduce the level of Proteobacteria in the intestinal flora . Moreover, Proteobacteria are gram‐negative bacteria; a higher level of Proteobacteria in the DEW group therefore leads to a higher amount of LPS in the intestine compared with the PEW group …”

Section: Discussionmentioning

confidence: 96%

A comparative study of the modulation of the gut microbiota in rats by dietary intervention with different sources of egg‐white proteins

Qiu

Meng

et al. 2020

J Sci Food Agric

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BACKGROUND Gut microflora dysbiosis has been related closely to a variety of diseases including obesity and inflammatory bowel disease. Proteins and peptides in egg white have been found to alleviate inflammation but the role played by the intestinal flora is still unclear. Using casein as a dietary protein control, we investigated the effects of diets composed of hen egg white, duck egg white, and preserved egg white on gut microbiota in the rat cecum. RESULTS The gut microbiota in rats were altered after egg‐white consumption. The results showed that rats fed with egg white had a similar overall structure of cecal bacterial communities, which was different from those fed with casein. The relative abundance of Akkermansia in the group of rats fed with hen egg white was highest among all groups. Rats fed with duck egg white had significantly higher relative abundance of Proteobacteria and Peptostreptococcaceae, and lower relative abundance of Lachnospiraceae. In addition, the levels of lipopolysaccharide (LPS) and lipopolysaccharide‐binding protein (LBP) in rats fed with duck egg white and preserved egg white were lower than the levels in rats fed with hen egg white. CONCLUSION Our results indicated the possible positive effect on homeostasis of the intestinal flora brought about by the intake of duck egg white. This study provides an insight into the potential positive impact of preserved egg white on health by changing gut microbiota and affecting the antigen load. © 2020 Society of Chemical Industry

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Glycated fish protein supplementation modulated gut microbiota composition and reduced inflammation but increased accumulation of advanced glycation end products in high-fat diet fed rats

Abstract: Glycated fish protein showed positively biological effects but increased AGEs accumulation in high-fat-diet-fed rats.

Cited by 27 publications

References 43 publications

Identification of gut microbiota and microbial metabolites regulated by an antimicrobial peptide lipocalin 2 in high fat diet-induced obesity

Identification of gut microbiota and microbial metabolites regulated by an antimicrobial peptide lipocalin 2 in high fat diet-induced obesity

Dietary advanced glycation end‐products: Perspectives linking food processing with health implications

A comparative study of the modulation of the gut microbiota in rats by dietary intervention with different sources of egg‐white proteins

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