Glycemia and Cardiovascular Risk

Stern, Michael P.

doi:10.2337/diacare.20.10.1501

Cited by 23 publications

(17 citation statements)

References 1 publication

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“…Though there is a general agreement that hyperglycaemia is associated with atherosclerosis, recent findings indicate that glycaemic level as a cardiovascular risk factor in the normal population and in diabetic subjects constitute two separate questions [22]. Several prospective studies have demonstrated that hyperglycaemia in non-diabetic subjects is predictive for subsequent development of CVD [5,7,11].…”

Section: Discussionmentioning

confidence: 99%

Relationship between fasting plasma glucose, atherosclerosis risk factors and carotid intima media thickness in non-diabetic individuals

Temelkova‐Kurktschiev¹,

Koehler²,

Schäper³

et al. 1998

Diabetologia

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Hyperglycaemia has been convincingly shown to be associated with increased occurrence of atherosclerosis [1±4]. Epidemiological studies found that patients with Type II (non-insulin-dependent) diabetes mellitus have a two-to four-fold increased relative risk of cardiovascular disease (CVD) in comparison to nondiabetic subjects [3]. Poorly controlled Type II diabetic patients have a higher risk than patients with good glycaemic control [1,4]. Furthermore, there is evidence that non-diabetic plasma glucose levels are also continuously associated with CVD [5±7], though this relationship has not been confirmed for only moderate degrees of hyperglycaemia [8±10]. So far, Diabetologia (1998) 41: 706±712

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Section: Discussionmentioning

confidence: 99%

Relationship between fasting plasma glucose, atherosclerosis risk factors and carotid intima media thickness in non-diabetic individuals

Temelkova‐Kurktschiev¹,

Koehler²,

Schäper³

et al. 1998

Diabetologia

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“…The concept that diabetes is associated with a pronounced increased risk of atherosclerotic cardiovascular disease is widely accepted [44]. The idea that increased cardiovascular disease risk is an attribute of diabetic hyperglycaemia has less consensus [22].…”

Section: Discussionmentioning

confidence: 99%

Impaired glucose tolerance, Type II diabetes mellitus and carotid atherosclerosis: prospective results from the Bruneck Study

et al. 2000

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Atherosclerotic vascular diseases such as myocardial infarction, stroke and lower extremity arteriopathy are well-known severe complications of impaired glucose tolerance (IGT) and Type II (non-insulin-dependent) diabetes mellitus [1±7] and account for up to 60±70 % of deaths in diabetic subjects [8]. Impaired glucose tolerance and Type II diabetic patients often have, however, multiple metabolic, haemodynamic and haemocoagulative defects such as high triglycerides and low HDL cholesterol, high blood pressure and high fibrinogen [9±15], which are cardiovascular risk factors in themselves [16]. These defects can precede the development of glucose intolerance by several years [17, 18]. Thus, the independent contribution of glucose intolerance and its bio- Diabetologia (2000) Abstracts Aims/hypothesis. Cardiovascular disease is a wellknown severe complication of impaired glucose tolerance and Type II (non-insulin-dependent) diabetes mellitus. The independent contribution of glucose intolerance to cardiovascular disease and the underlying pathogenic mechanisms are still, however, not clear. Methods. In this prospective population-based study, 826 subjects aged 40±79 years underwent high resolution duplex ultrasound examinations of carotid arteries and extensive clinical and laboratory screenings for potential vascular risk factors at baseline and 5 years later. The ultrasound protocol involved measurements of maximum axial diameter of atherosclerotic plaques, if any, in common and internal carotid arteries on both sides and enable differentiation of two main stages in carotid artery disease, termed early non-stenotic and advanced stenotic atherosclerosis. Intima-media thickness was assessed at the follow-up examination. Results. Type II diabetes and, to a lesser extent, impaired glucose tolerance were found to be statistically significant risk predictors of 5-year changes in carotid atherosclerosis. These associations were in part independent of other vascular risk factors typically clustering with glucose intolerance. Both impaired glucose tolerance and Type II diabetes mellitus were not independently related to early non-stenotic atherosclerosis. In contrast, Type II diabetes mellitus was the strongest single risk predictor of advanced stenotic atherosclerosis [odds ratio 5.0 (95 % confidence intervals 2.3±11.1)] and impaired glucose tolerance was of relevance as well [odds ratio 2.8 (1.2±6.4)] (p < 0.001). Conclusion/interpretation. Impaired glucose tolerance and, to a greater extent, Type II diabetes were strong independent predictors of advanced carotid atherosclerosis in our prospective population-based study. [Diabetologia (2000) 43: 156±164]

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“…C 2005 by the International Society of Nephrology cause of morbidity and mortality among type 2 diabetic patients, and that an estimated 75% to 85% of diabetics die because of cardiovascular disease as a consequence of an accelerated atherosclerotic process [1,2].…”

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confidence: 99%

Cardiovascular risk factors in type 2 diabetic patients: Multifactorial intervention in primary care

Tranche¹,

Galgo²,

Mundet³

et al. 2005

Kidney International

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Glycemia and Cardiovascular Risk

Cited by 23 publications

References 1 publication

Relationship between fasting plasma glucose, atherosclerosis risk factors and carotid intima media thickness in non-diabetic individuals

Relationship between fasting plasma glucose, atherosclerosis risk factors and carotid intima media thickness in non-diabetic individuals

Impaired glucose tolerance, Type II diabetes mellitus and carotid atherosclerosis: prospective results from the Bruneck Study

Cardiovascular risk factors in type 2 diabetic patients: Multifactorial intervention in primary care

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