Glycemia and venous thromboembolism in patients with primary brain tumors – A speculative review

Orešković, Darko; Kaštelančić, Anđelo; Raguž, Marina; Almahariq, Fadi; Romić, Dominik; Dlaka, Domagoj; Janeš, Andrea; Milotić, Vivian; Novaković, Sabina; Chudy, Darko

doi:10.1016/j.mehy.2021.110719

Cited by 3 publications

(1 citation statement)

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“…This should be performed not just because of the possible connection of glycaemia and tumor proliferation, but also because of the many potentially severe complications occurring due to unrecognized hyperglycemia during peri- and post-operative treatment [ 85 ]. Notably, hyperglycemia in brain tumor patients could also be important in the context of venous thromboembolism [ 86 ]. Also, of note is that we only investigated patients who underwent open surgery.…”

Section: Discussionmentioning

confidence: 99%

Chronic hyperglycemia and intracranial meningiomas

Orešković,

Madero Pohlen,

Cvitković

et al. 2024

BMC Cancer

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Meningiomas are among the most common primary tumors of the central nervous system. Previous research into the meningioma histological appearance, genetic markers, transcriptome and epigenetic landscape has revealed that benign meningiomas significantly differ in their glucose metabolism compared to aggressive lesions. However, a correlation between the systemic glucose metabolism and the metabolism of the tumor hasn’t yet been found. We hypothesized that chronic levels of glycaemia (approximated with glycated hemoglobin (HbA1c)) are different in patients with aggressive and benign meningiomas. The study encompassed 71 patients with de novo intracranial meningiomas, operated on in three European hospitals, two in Croatia and one in Spain. Our results show that patients with WHO grade 2 meningiomas had significantly higher HbA1c values compared to patients with grade 1 lesions (P = 0.0290). We also found a significant number of patients (19/71; 26.7%) being hyperglycemic, harboring all the risks that such a condition entails. Finally, we found a significant correlation between our patients’ age and their preoperative HbA1c levels (P = 0.0008, ρ(rho) = 0.388), suggesting that older meningioma patients are at a higher risk of having their glycaemia severely dysregulated. These findings are especially important considering the current routine and wide-spread use of corticosteroids as anti-edematous treatment. Further research in this area could lead to better understanding of meningiomas and have immediate clinical impact.

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Section: Discussionmentioning

confidence: 99%