Glycemic control and the production of cytokines in diabetic patients with chronic periodontal disease

Abstract

ObjectiveTo evaluate the association of glycemic control and cytokine production in type 2 diabetic subjects with chronic periodontitis Methods Gingival biopsies were performed in 40 patients, divided into four groups: systemically healthy subjects without periodontal disease (S); systemically healthy patients with chronic periodontitis (P); patients with well-controlled type 2 diabetes mellitus (DM) with chronic periodontitis (C); poorly controlled type 2 diabetes mellitus with chronic periodontitis (D). The production of interleukin (IL) -4, -6, -10, -17 and interferon (IFN) -γ was quantified by ELISA. Results The production of IL-4, IL-10, IL-17 and INF-γ was higher on group D when compared to other groups (p <0.05), which in turn were similar (p ≥0.05). In addition, there was no difference in the production of IL-6 in any of the evaluated groups (p≥0.05). ConclusionWere observed significantly elevated levels of pro-inflammatory and anti-inflammatory cytokines in patients with poorly controlled type 2 diabetes and chronic periodontitis, demonstrating that glycemic control may be associated to the immune inflammatory response of sites with chronic periodontitis.

The amelioration effect of antidiabetic agents on cytokine expression in patients with type 2 diabetes mellitus

“…Patients with T2DM might produce more IL-17 than healthy controls ( Telikani et al, 2019 ). Franco et al ( Franco et al, 2017 ) have shown significantly elevated IL-17 levels when cases T2DM is not well controlled. Additionally, T cells induce chronic inflammation in cases with diabetes by producing IL-17 ( Jagannathan-Bogdan et al, 2011 ).…”

Gene expression of inflammatory immune factors and clinical parameters in diabetes and nondiabetes patients with periodontal disease

“…Twenty-one patients (14 non-diabetics -NDM and 7 diabetics -DM), aged 42 to 64 years, were selected to participate in this study. Samples size was based on previous pilot studies evaluating inflammatory markers in patients with periodontitis and diabetes (Longo et al, 2015;Mesia et al, 2016;Franco et al, 2017). All subjects were recruited from the Department of Periodontology, School of Dentistry, Fluminense Federal University -UFF, Nova Friburgo, Rio de Janeiro State, Brazil, for a period between 2013 and 2017.…”