Glycemic Durability of Rosiglitazone, Metformin, or Glyburide Monotherapy

Kahn, Steven E.; Sm, Haffner; Ma, Heise; Herman, WH; Holman, R; Jones, Norman; Bg, Kravitz; Lachin, John M.; Mc, O'Neill; Zinman, Bernard; Viberti, Giancarlo

doi:10.1056/nejmoa066224

Cited by 2,726 publications

(2,322 citation statements)

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“…Most of the recently published data have indicated that thiazolidinediones-associated fractures are restricted to the upper limb (forearm, hand and wrist) or distal lower limb (foot, ankle, fibula and tibia) [11]. Our study investigated the association between thiazolidinediones use and different fracture sites.…”

Section: Discussionmentioning

confidence: 98%

“…Since 2004, preclinical [3][4][5][6][7] and clinical studies [8][9][10] have indicated that thiazolidinediones use could alter bone metabolism, resulting in reduced osteoblastic bone formation and accelerated bone loss. As suggested by recent evidence from an epidemiological study [9] and a clinical trial [11], thiazolidinediones use is associated with a decrease in bone density in postmenopausal women. Similar findings have been reported in older men with type 2 diabetes [8].…”

Section: Introductionmentioning

confidence: 94%

“…Evidence that thiazolidinediones increase fracture risk emerged with the adverse events reports of the A Diabetes Outcome and Progression Trial (ADOPT) [11,12] published in 2006. Although a case-control study by Meier et al [13] provided further evidence of a possible association between thiazolidinediones use and fractures in patients with diabetes mellitus, a dose-response relationship was not confirmed due to the relatively few patients using thiazolidinediones in case and control groups.…”

Section: Introductionmentioning

confidence: 99%

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The association between thiazolidinediones and hospitalisation for fracture in type 2 diabetic patients: a Taiwanese population-based nested case–control study

Hsiao

Mullins

2009

Diabetologia

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Aims/hypothesis Evidence from the USA has emerged that thiazolidinediones may have a negative effect on the skeleton and increase the risk of fracture, but the association between thiazolidinediones use and fractures has not been evaluated in an Asian population. Using the 2000-2005 Taiwan National Health Insurance claims database, this Taiwanese populationbased nested case-control study explored the association between thiazolidinediones use and hospitalisation for bone fracture in type 2 diabetic patients. Methods In the study cohort of type 2 diabetic patients, we identified 18,003 patients with fracture and 90,015 matched controls. Multivariable conditional logistic regressions were used to estimate the association between exposure to thiazolidinediones and fractures. Duration of thiazolidinediones use was defined on the basis of cumulative days of exposure to thiazolidinediones during the year prior to the index date, i.e. <30 days, 30 to 180 days and >180 days. Results More type 2 diabetic patients with fractures than controls used thiazolidinediones (fractures 5.99% vs control 4.06%). Thiazolidinediones use was associated with hospitalisation for fracture and the association was stronger with longer term exposure to thiazolidinediones (<30 Conclusions/interpretation Long-term exposure of type 2 diabetic patients to thiazolidinediones was associated with higher odds of fractures among women without a significant increase in odds of fractures among men.

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

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The association between thiazolidinediones and hospitalisation for fracture in type 2 diabetic patients: a Taiwanese population-based nested case–control study

Hsiao

Mullins

2009

Diabetologia

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“…If the hypothesis that hypersecretion contributes to the progressive destruction of the beta cell is correct, it would have major implications for how type 2 diabetes should be treated. Perhaps the most compelling results suggesting a need for a change in practice have come from the a Diabetes Outcome Progression Trial (ADOPT) [49]. In this study, the clinical endpoint was failure of monotherapy drug treatment as reflected by a fasting plasma glucose level of greater than 10 mmol/l in newly diagnosed patients with type 2 diabetes.…”

Section: Clinical Consequencesmentioning

confidence: 99%

Too much of a good thing: why it is bad to stimulate the beta cell to secrete insulin

et al. 2008

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“…4,32 In type 2 diabetics, thiazolidinedione improved glucose control despite significant weight gain. 33 Importantly, fat incretion occurred mostly in peripheral subcutaneous adipose tissue, often in the absence of any changes in visceral mass, resulting in a more favorable PFM/CFM ratio. [34][35][36][37] Redistribution of fat mass from peripheral locations to abdominal depots following a carbohydrate-enriched diet also led to diminished insulin sensitivity.…”

Section: Discussionmentioning

confidence: 99%

Body fat distribution modulates insulin sensitivity in post-menopausal overweight and obese women: a MONET study

et al. 2008

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Objective: Central fat mass (CFM) correlates with insulin resistance and increases the risk of type 2 diabetes and cardiovascular complications. On the other hand, increased peripheral fat mass (PFM) is associated with higher insulin sensitivity. Thus, we examined the contribution of adipose tissue distribution, as assessed by the PFM/CFM ratio, to insulin sensitivity in overweight and obese postmenopausal women. Design and methods: A total of 124 nondiabetic overweight and obese postmenopausal women underwent an oral glucose tolerance test (OGTT) and a hyperinsulinemic/euglycemic (HI) clamp. Body composition was determined using computed tomography for visceral adipose tissue (VAT) and dual X-ray absorptiometry for fat mass, lean body mass and their respective proportions. Participants were divided by tertiles of the PFM/CFM ratio. Results: Participants with preferential CFM (group 1) had higher fasting insulin levels and insulin area under the curve (AUC) during OGTT, as well as lower glucose infusion rates during the HI clamp, whether it was expressed per kg of body weight (M) or per kg of fat-free mass (Mm), compared with the other two groups. The PFM/CFM ratio also correlated significantly with fasting insulin (r ¼ À0.32, Po0.001), the insulin AUC (r ¼ À0.42 Po0.001), M (r ¼ 0.39 Po0.001) and Mm (r ¼ 0.37 Po0.001). Using hierarchical regression, we demonstrated that the PFM/CFM ratio was an independent predictor of insulin AUC, M and Mm and that its sequential addition to CFM and VAT improved significantly the predictive value of the model for insulin sensitivity for all variables except fasting insulin. Conclusion: The PFM/CFM ratio, which integrates the antagonistic effects of both central and peripheral depots on insulin sensitivity, added substantially to the prediction of insulin sensitivity over VAT and CFM alone.

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Glycemic Durability of Rosiglitazone, Metformin, or Glyburide Monotherapy

Abstract: The potential risks and benefits, the profile of adverse events, and the costs of these three drugs should all be considered to help inform the choice of pharmacotherapy for patients with type 2 diabetes. (ClinicalTrials.gov number, NCT00279045 [ClinicalTrials.gov].).

Cited by 2,726 publications

References 32 publications

The association between thiazolidinediones and hospitalisation for fracture in type 2 diabetic patients: a Taiwanese population-based nested case–control study

The association between thiazolidinediones and hospitalisation for fracture in type 2 diabetic patients: a Taiwanese population-based nested case–control study

Too much of a good thing: why it is bad to stimulate the beta cell to secrete insulin

Body fat distribution modulates insulin sensitivity in post-menopausal overweight and obese women: a MONET study

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