Glycemic, inflammatory and oxidative stress responses to different high-intensity training protocols in type 1 diabetes: A randomized clinical trial

Advanced glycation end‐products and their receptors: Exercise effects

“…2 The exercise-induced reductions of AGEs would stem from endogenous AGEs' metabolisms and not from the dietary sources. In the present review, we observed that exercise could reduce sRAGEs levels, 5,7 while inconsistent changes of sRAGEs were seen with diets. 1 There appears to be a different mechanism behind the interventions by diets vis-a-vis by exercise (although only two exercise interventional studies were available).…”

“…Two reports (including one report of a randomized control trial [RCT]) with a diet and exercise intervention 2,3 and five reports (including one RCT) with an exercise intervention 4-8 were selected (Table 1). Except for two studies, 3,7 the intervention produced significant weight loss. [4][5][6] Five studies measured the AGEs levels, which demonstrated significant reductions by a diet and exercise intervention 2,3 and an exercise intervention.…”

“…sRAGEs levels, demonstrating significant reductions of sRAGEs by an exercise intervention. 5,7 Similar to the intervention of diets and bariatric surgeries, 1 exercise generally reduces the AGEs levels with weight loss, although one RCT suggested diets to be better than exercise for the reduction of AGEs. 2 The exercise-induced reductions of AGEs would stem from endogenous AGEs' metabolisms and not from the dietary sources.…”

Reply to letter to the editor: “Advanced glycation end‐products and their receptors: Exercise effects”

“…3 In their letter, Kotani and Gugliucci searched and compiled data from interventional studies in which the effects of physical exercise on AGEs and soluble AGEs receptors (sRAGE) were evaluated. [4][5][6][7][8][9][10] Based on those studies, the authors concluded that the practice of physical exercise could reduce serum AGEs and, seemingly contradictory, it also reduces sRAGE concentrations. 1 However, we would advert caution before drawing these conclusions.…”

Effects of acute exercise on glucose control in type 1 diabetes: A systematic review

“…Exercise has been encouraged as part of routine care of T1D and there have been several reviews and intervention studies examining the effects of exercise in T1D but an optimal prescription, intensity, and modality have not yet been established . Moreover, in individuals with T1D, common barriers to exercise (lack of time, work‐related factors, access to facilities, lack of motivation, fear of hypoglycemia) contribute to low physical activity rates .…”