2008
DOI: 10.1210/er.2008-0007
|View full text |Cite
|
Sign up to set email alerts
|

Glycerolipid Metabolism and Signaling in Health and Disease

Abstract: Maintenance of body temperature is achieved partly by modulating lipolysis by a network of complex regulatory mechanisms. Lipolysis is an integral part of the glycerolipid/free fatty acid (GL/FFA) cycle, which is the focus of this review, and we discuss the significance of this pathway in the regulation of many physiological processes besides thermogenesis. GL/FFA cycle is referred to as a "futile" cycle because it involves continuous formation and hydrolysis of GL with the release of heat, at the expense of A… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

6
258
0
2

Year Published

2009
2009
2024
2024

Publication Types

Select...
8
1

Relationship

1
8

Authors

Journals

citations
Cited by 270 publications
(266 citation statements)
references
References 346 publications
(358 reference statements)
6
258
0
2
Order By: Relevance
“…Speaking of glycolysis, in chronic liv-er injury, energy production will change from mitochondrial respiration to glycolysis which plays a key role in energy metabolism in the liver (Nishikawa et al, 2014). The liver is the main organ for the metabolism of glucose and lipid (Bou Khalil et al, 2010;Hammond et al, 2002) and when lesion occurs, the liver may dysfunction including abnormal glycolysis/gluconeogenesis and glycerolipid metabolism (Prentki and Madiraju, 2008;Dwyer et al, 2012).…”
Section: Discussionmentioning
confidence: 99%
“…Speaking of glycolysis, in chronic liv-er injury, energy production will change from mitochondrial respiration to glycolysis which plays a key role in energy metabolism in the liver (Nishikawa et al, 2014). The liver is the main organ for the metabolism of glucose and lipid (Bou Khalil et al, 2010;Hammond et al, 2002) and when lesion occurs, the liver may dysfunction including abnormal glycolysis/gluconeogenesis and glycerolipid metabolism (Prentki and Madiraju, 2008;Dwyer et al, 2012).…”
Section: Discussionmentioning
confidence: 99%
“…The beta cell mass at 3 weeks is almost normalised, consistent with the compensation phase being associated with enhanced beta cell growth and neogenesis. Furthermore, accelerated GL/FA cycling may be involved in the compensation [39] as well as allowing fuel excess detoxification and lipoadaptation [42,43]. Circulating glucose, triacylglycerol (TAG) and NEFA levels rise after 1 week post-Px, such that beta cells are in a glucolipotoxic environment.…”
Section: Discussionmentioning
confidence: 99%
“…Fatty acid oxidation, however, could be a mechanism of detoxification of cellular lipid content and therefore could be protective, particularly in situations of increased GL/FA cycling. We have proposed a role for GL/FA cycling in the glucolipodetoxification process [42,43]. Very active GL/FA cycling, together with enhanced fat oxidation, may explain why ZF-Px islets did not accumulate triacylglycerol despite elevated glycaemia and circulating triacylglycerol levels amounting to glucolipotoxic conditions.…”
Section: Sg Autophagymentioning
confidence: 92%
“…All these steps lead to an elevation of cytosolic malonyl-CoA and long-chain-acylCoA. This model has it pros and cons, which have been reviewed extensively elsewhere [12,48]. Our recent studies [25,38], as well as others [49][50][51] have now shown a consistent lack of evidence for a direct role of malonyl-CoA in regulation of GSIS, whereas its potential role in lipid-mediated potentiation of GSIS remains a possibility.…”
Section: Discussionmentioning
confidence: 97%