Glycerophospholipid profile in oncogene-induced senescence

Cadenas, Cristina; Vosbeck, Sonja; Hein, Eva Maria; Hellwig, Birte; Langer, Alice; Hayen, Heiko; Franckenstein, Dennis; Büttner, Bettina; Hammad, Seddik; Marchan, Rosemarie; Hermes, Matthias; Selinski, Silvia; Rahnenführer, Jörg; Peksel, Begüm; Török, Zsolt; Vı́gh, László; Hengstler, Jan G.

doi:10.1016/j.bbalip.2011.11.008

Cited by 48 publications

(50 citation statements)

References 49 publications

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“…In our study, the down-regulated DEGs were also enriched in metabolism related pathways. For instance, Chpt1 was enriched in glycerophospholipid metabolism, which was in accordance with the findings of Cadenas et al [33], that was, the down-regulation of Chpt1 was responsible for glycerophospholipid and cholesterol metabolism. Therefore, we speculated that the changes of metabolism related pathways in kidney IR injury might be due to the down-regulation of Chpt1.…”

Section: Discussionsupporting

confidence: 79%

Identification of Genes and Pathways Associated with Kidney Ischemia-Reperfusion Injury by Bioinformatics Analyses

Wang

Tang²,

Ye³

et al. 2016

Kidney Blood Press Res

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Background/Aims: Ischemia-reperfusion (IR) injury in the kidney is a major cause of acute kidney injury in humans. However, the molecular mechanisms responsible for the progression of kidney IR injury still need to be explored. In this study, we aimed to explore the underlying genes and pathways associated with kidney IR injury. Methods: Gene microarray of GSE27274 was downloaded from the Gene Expression Omnibus database. The differentially expressed genes (DEGs) between kidney IR injury and kidney IR rat samples were analyzed. Gene Ontology biological process (BP) and pathway enrichment analyses of DEGs were performed, followed by protein-protein interaction (PPI) network construction. Results: A total of 88 up-regulated and 102 down-regulated DEGs were identified. The up-regulated DEGs including FK506 binding protein 1A (Fkb1a) were mainly enriched in biological processes (BPs) related to protein ubiquitination. The down-regulated DEGs including complement component 5 (C5) were enriched in complement and coagulation cascades pathway. Choline phosphotransferase 1 (Chpt1) was enriched in glycerophospholipid metabolism pathway. In the PPI network, heme oxygenase (decycling) 1 (Hmox1) was as a hub gene that interacted with the maximum nodes. Conclusions: DEGs of Fkb1a, C5, Chpt1, and Hmox1, as well as complement and coagulation cascades pathway, glycerophospholipid metabolism pathway, and BP terms related to protein ubiquitinatione may be the potential targets for diagnosis and treatment of kidney IR injury.

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Section: Discussionsupporting

confidence: 79%

Identification of Genes and Pathways Associated with Kidney Ischemia-Reperfusion Injury by Bioinformatics Analyses

Wang

Tang²,

Ye³

et al. 2016

Kidney Blood Press Res

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“…Biomarkers of other possibly relevant mechanisms, such as redox control, 20 mechanoactivity 21 and the tumor metabolome and lipidome 17 , 22 , 23 still need to be evaluated. However, a perspective for the near future is that we are close to fully understanding the mechanisms responsible for the Janus-faced nature of the immune system.…”

Section: Future Perspectives: Understanding the Janus-faced Immune Symentioning

confidence: 99%

Immunoglobulin kappa chain as an immunologic biomarker of prognosis and chemotherapy response in solid tumors

Schmidt¹,

Micke

Gehrmann

et al. 2012

OncoImmunology

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“…The profiling was carried out by the previously described HPLC/LIT-FTICRMS-method [13] including automated data processing by the Profiler-Merger-Viewer software [14], of which the applicability for different complex GP samples was demonstrated recently [15,16]. …”

Section: Introductionmentioning

confidence: 99%

Comparative Lipidomic Profiling of S. cerevisiae and Four Other Hemiascomycetous Yeasts

Hein

Hayen

2012

Metabolites

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Glycerophospholipids (GP) are the building blocks of cellular membranes and play essential roles in cell compartmentation, membrane fluidity or apoptosis. In addition, GPs are sources for multifunctional second messengers. Whereas the genome and proteome of the most intensively studied eukaryotic model organism, the baker’s yeast (Saccharomyces cerevisiae), are well characterized, the analysis of its lipid composition is still at the beginning. Moreover, different yeast species can be distinguished on the DNA, RNA and protein level, but it is currently unknown if they can also be differentiated by determination of their GP pattern. Therefore, the GP compositions of five different yeast strains, grown under identical environmental conditions, were elucidated using high performance liquid chromatography coupled to negative electrospray ionization-hybrid linear ion trap-Fourier transform ion cyclotron resonance mass spectrometry in single and multistage mode. Using this approach, relative quantification of more than 100 molecular species belonging to nine GP classes was achieved. The comparative lipidomic profiling of Saccharomyces cerevisiae, Saccharomyces bayanus, Kluyveromyces thermotolerans, Pichia angusta, and Yarrowia lipolytica revealed characteristic GP profiles for each strain. However, genetically related yeast strains show similarities in their GP compositions, e.g., Saccharomyces cerevisiae and Saccharomyces bayanus.

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Glycerophospholipid profile in oncogene-induced senescence

Cited by 48 publications

References 49 publications

Identification of Genes and Pathways Associated with Kidney Ischemia-Reperfusion Injury by Bioinformatics Analyses

Identification of Genes and Pathways Associated with Kidney Ischemia-Reperfusion Injury by Bioinformatics Analyses

Immunoglobulin kappa chain as an immunologic biomarker of prognosis and chemotherapy response in solid tumors

Comparative Lipidomic Profiling of S. cerevisiae and Four Other Hemiascomycetous Yeasts

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