Glycine suppresses TNF-alpha-induced activation of NF-κB in differentiated 3T3-L1 adipocytes

Blancas-Flores, Gerardo; Alarcón-Aguilar, Francisco Javier; García‐Macedo, Rebeca; Almanza-Perez, Julio César; Flores-Saenz, José Luis; Román-Ramos, Rubén; Ventura-Gallegos, José Luis; Kumate, J; Zentella‐Dehesa, Alejandro; Cruz, Miguel

doi:10.1016/j.ejphar.2012.06.025

Cited by 31 publications

(27 citation statements)

References 36 publications

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“…Adipocyte differentiation‐stimulated phosphorylation of Akt and CREB was dramatically reduced by AITC treatment ( Figure A). It was recently reported that glycine decreased TNF‐α‐dependent NF‐κB activation in differentiated 3T3‐L1 adipocytes and that it could be used as an alternative treatment for chronic inflammation associated with obesity . We investigated whether AITC can modulate NF‐κB activation in differentiated 3T3‐L1 adipocytes.…”

Section: Resultsmentioning

confidence: 99%

Allyl Isothiocyanate Ameliorates Obesity by Inhibiting Galectin‐12

Chen

et al. 2018

Molecular Nutrition Food Res

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Section: Resultsmentioning

confidence: 99%

Allyl Isothiocyanate Ameliorates Obesity by Inhibiting Galectin‐12

Chen

et al. 2018

Molecular Nutrition Food Res

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“…The immune protective function of glycine may be related to reduced levels of pro-inflammatory cytokines and elevated levels of anti-inflammatory cytokines in the plasma, which interfere with TNF-α/NF-κB signal transduction pathways [89]. Similarly, glycine protects the liver from bile duct ligation-induced injury through alleviating oxidative stress and apoptosis [90].…”

Section: Accepted Manuscriptmentioning

confidence: 98%

Nutritional epigenetics with a focus on amino acids: implications for the development and treatment of metabolic syndrome

Dai

et al. 2016

The Journal of Nutritional Biochemistry

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“…Mauriz et al (2001) reported that glycine inhibited the activation of NF-B in the liver, reducing damage in response to haemorrhagic shock. Recently, we reported that glycine suppresses NF-B activation in 3T3-L1 adipocytes and diminishes the expression of proinflammatory genes (Blancas-Flores et al 2012).…”

Section: Figmentioning

confidence: 99%

Vascular endothelial function is improved by oral glycine treatment in aged rats

Gómez-Zamudio

García‐Macedo

Ibarra-Barajas

et al. 2015

Can. J. Physiol. Pharmacol.

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Glycine has been used to reduce oxidative stress and proinflammatory mediators in some metabolic disorders; however, its effect on the vasculature has been poorly studied. The aim of this work was to explore the effect of glycine on endothelial dysfunction in aged rats. Aortic rings with intact or denuded endothelium were obtained from untreated or glycine-treated male Sprague-Dawley rats at 5 and 15 months of age. Concentration-response curves to phenylephrine (PHE) were obtained from aortic rings incubated with N(G)-nitro-l-arginine methyl ester (l-NAME), superoxide dismutase (SOD), indomethacin, SC-560, and NS-398. Aortic mRNA expression of endothelial nitric oxide synthase (eNOS), NADPH oxidase 4 (NOX-4), cyclooxygenase 1 (COX-1), cyclooxygenase 2 (COX-2), tumour necrosis factor (TNF)-α, and interleukin-1 β was measured by real time RT-PCR. The endothelial modulation of the contraction by PHE was decreased in aortic rings from aged rats. Glycine treatment improved this modulator effect and increased relaxation to acetylcholine. Glycine augmented the sensitivity for PHE in the presence of l-NAME and SOD. It also reduced the contraction by incubation with indomethacin, SC-560, and NS-398. Glycine increased the mRNA expression of eNOS and decreased the expression of COX-2 and TNF-α. Glycine improved the endothelium function in aged rats possibly by enhancing eNOS expression and reducing the role of superoxide anion and contractile prostanoids that increase the nitric oxide bioavailability.

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Glycine suppresses TNF-alpha-induced activation of NF-κB in differentiated 3T3-L1 adipocytes

Cited by 31 publications

References 36 publications

Allyl Isothiocyanate Ameliorates Obesity by Inhibiting Galectin‐12

Allyl Isothiocyanate Ameliorates Obesity by Inhibiting Galectin‐12

Nutritional epigenetics with a focus on amino acids: implications for the development and treatment of metabolic syndrome

Vascular endothelial function is improved by oral glycine treatment in aged rats

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