Glycoclusters and Glycodendrimers

Niedzwiecka, Anna; Achebe, Nnenna; Ling, Chang‐Chun

doi:10.1016/b978-0-12-819475-1.00039-0

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2024

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“…CDs have a frustum shape with primary hydroxyl groups (OH-6’s) on the narrower end (primary face) and secondary hydroxyl groups on the wider end (secondary face). Both faces of CDs feature polar groups, rendering them water-soluble, in their native forms; this makes CDs advantageous over other macrocyclic hosts [ 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 ]. All native CDs display axial symmetry, with C3-H3 and C5-H5 bonds symmetrically oriented toward the center of the cavity.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Inclusion Properties of a β-Cyclodextrin Heptaphosphoramidate

Che,

Espejo,

Ling

2024

Molecules

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In this study, we report a novel per-6-substituted β-cyclodextrin (4) featuring seven phosphoramidate moieties as an innovative host for inclusion. This structurally well-defined host has remarkable water solubility and was isolated in pure form. Analytical techniques such as NMR and ITC were used to probe the molecular interactions with different drug molecules. Our investigations revealed that host 4 can form 2:1 inclusion complexes with various drugs. Further studies showed that the inclusions of drugs by β-CD host (4) are mostly enthalpy driven, highlighting the potential roles played by the phosphoramidate functionalities of the host. Comparatively, a per-O2, O3-acetylated analog (6) of compound 4 was also obtained, which also shows unusual water solubility but diminished inclusion capability.

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