“…Low expression of enriched genes such as CYP2C19 [Ashida et al 2018], ABAT (4-aminobutyrate aminotransferase) [Jansen et al 2015], ACOX1 [Chen et al 2018], ACSM3 [Ruan et al 2017], FBP1 [Liu et al 2018], ST3GAL6 [Souady et al 2011], AGXT (alanine--glyoxylate and serine-- pyruvate aminotransferase) [Sun et al 2019], ALDOB (aldolase, fructose-bisphosphate B) [Tao et al 2015], ALDH6A1 [Shin et al 2020], XDH (xanthine dehydrogenase) [Chen et al 2017], OGDHL (oxoglutarate dehydrogenase like) [Jiao et al 2019], CYP2C8 [Li et al 2019], CYP2C9 [Yu et al 2015], CYP3A5 [Jiang et al 2015], BHMT (betaine--homocysteine S-methyltransferase) [Jin et al 2016], TAT (tyrosine aminotransferase) [Fu et al 2010], SLC27A5 [Gao et al 2020], GYS2 [Chen et al 2019], GLYAT (glycine-N-acyltransferase) [Matsuo et al 2012], CES3 [Quiroga et al 2016], MASP2 [Ding et al 2014], C7 [Seol et al 2016] and F11 [Du et al 2019] were involved in progression of hepatocellular carcinoma, but decrease expression these genes may be identified with growth of hepatoblastoma. Enriched genes such as SULT1A2 [Fernandez-Santander et al 2013], PIK3C2G [Li et al 2015], AGL (amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase) [Richmond et al 2018], UGT2B10 [Lu et al 2018], CTH (cystathionine gamma-lyase) [Xu et al 2020] and CYP26A1 [Osanai and Lee, 2015] were involved in metabolic activity of various cancer types, but these genes may liable for metabolic activity of in hepatoblastoma. Enriched genes such as TDO2 [Pham et al 2018], EPHX2 [Vainio et al 2011], PLA2G2A [Ganesan et al 2008], INPP1 [Li et al 2019], GCH1 [Gao et al 2016], GNE (glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase) [Kemmner et al 2012], PAPSS2 [Zhang et al 2019], GLYATL1 [Eich et al 2019], CFB (complement factor B) [Kim et al 2019], C1R [Riihilä et al 2020], C1S [Riihilä et al 2020], C9 [Chong et al 2010], FGB (fibrinogen beta chain) [Repetto et al 2018] and KNG1 [Quesada-Calvo et al 2017] were linked with development of various cancer types, but these genes may be culpable for advancement of hepatoblastoma.…”