Glycogen-rich clear cell carcinoma of the breast

Markopoulos, Christos; Mantas, D.; Philipidis, T; Kouskos, Efstatios; Antonopoulou, Zoi; Hatzinikolaou, ML; Gogas, Helen

doi:10.1186/1477-7819-6-44

Cited by 28 publications

(41 citation statements)

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“…The patient is well today and has had no clinical recurrence of the disease after 2.5 years of follow-up without radiotherapy or chemotherapy. Markopoulos et al 13 recently reported a patient with GRCC who was free of the disease 48 months after surgery. The prognosis is probably better if the tumor is detected early and if there are no lymph node metastases.…”

Section: Discussionmentioning

confidence: 97%

“…Some investigators have reported that mammography revealed a malignant mass with an irregular margin and spicula formation with fi ne calcifi cation. [8][9][10][11][12] Markopoulos et al 13 reported that mammography disclosed a 3.5-cm lobulated, circumscribed mass with no evidence of malignancy, which suggested a fi broadenoma. In this study, mammography could not identify the tumor behind the dense breast tissues.…”

Section: Discussionmentioning

confidence: 99%

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Glycogen-rich clear cell carcinoma of the breast: a case report

et al. 2009

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Glycogen-rich clear cell carcinoma (GRCC) of the breast is a rare malignant breast tumor. We recently encountered a case of GRCC and report our imaging findings here. The patient was a 49-year-old woman with a mass in her right breast. Mammographic study showed no definite mass shadow because the breast was dense. No calcifications were identified. Ultrasonography disclosed a hypoechoic mass that had a diameter of 1.3 cm, partially irregular borders, heterogeneous internal echoes, and posterior acoustic enhancement, suggesting an invasive carcinoma. Histologic study of core needle biopsy specimens showed a solid proliferation of large clear carcinoma cells, suggestive of a ductal carcinoma. The carcinoma cells possessed clear cytoplasm larger than that typical of ductal carcinoma cells. Breast-conserving surgery was performed with axillary sentinel lymph node biopsy. Macroscopically, the tumor was a solid, white-yellow mass with fairly well defined margins. Histologic examination of the tumor showed a characteristic feature of GRCC: the tumor cells were positive for estrogen receptor but negative for progesterone receptor and Her 2, and the sentinel lymph node was histologically negative. The patient remains well and has had no clinical recurrence of the disease after 2.5 years of follow-up without radiotherapy or adjuvant therapy. Noteworthy is the usefulness of mammography and ultrasonography, which should be used as complementary imaging tools.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Glycogen-rich clear cell carcinoma of the breast: a case report

et al. 2009

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“…There are insufficient published data about the imaging characteristics of GRCCC [12,17]. The mammogram may be inconclusive due to dense breast tissue [17], and the tumor may have benign characteristics on mammography [18]. Some authors have suggested that GRCCC is associated with an aggressive clinical course [2,3] compared to conventional ductal carcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…Some authors have suggested that GRCCC is associated with an aggressive clinical course [2,3] compared to conventional ductal carcinoma. The clinical course of patients with GRCCC may vary depending on histological characteristics such as low grade and positive ER expression [18]. Further studies are however needed to better determine the behavior and prognosis of GRCCC [1,17].…”

Section: Discussionmentioning

confidence: 99%

Intraductal Glycogen-Rich Clear Cell Carcinoma of the Breast: A Rare Presentation and Review of the Literature

Salemis¹

2012

Breast Care

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Background: Glycogen-rich clear cell carcinoma of the breast is a rare histological subtype of breast cancer, accounting for 0.9–2.8% of all breast cancer cases. Fewer than 100 cases have been reported in the literature. Most of these tumors are invasive carcinomas. The intraductal glycogen-rich clear cell carcinoma is a very rare occurrence. Case Report: Herein is described a case of a pure intraductal glycogen-rich clear cell carcinoma of the breast in a 42-year-old premenopausal woman. A literature review has also been carried out. Mammography was inconclusive due to the presence of dense breast tissue, but magnetic resonance imaging (MRI) showed several nodular lesions measuring 7 × 6 cm in diameter and involving the upper aspect of the right breast suggestive of multifocal malignancy. A modified radical mastectomy was performed. The patient started hormonal therapy with tamoxifen and is currently well 16 months after surgery. Conclusion: A pure intraductal glycogen-rich clear cell carcinoma of the breast is a very rare occurrence. The case presented here exhibited uncommon MRI features, whereas the tumor size is one of the largest reported in the literature. Mammography may be inconclusive in the presence of dense breast tissue, but MRI is of great importance in the preoperative evaluation of the patient.

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“…The tumor characteristics of invasive cancer associated with PD are more aggressive than those of invasive cancer not associated with PD. GRCCC of the breast is a rare sub¬type of invasive duc- tal carcinoma and generally tends to follow an aggressive clinical course (11,12).…”

Section: Case Reportmentioning

confidence: 99%