Glycogenolysis during short-term fasting in malaria and healthy subjects?the potential regulatory role of glycogen content on glycogen breakdown: a hypothesis

Sprangers, F.; Thien, Huynh Van; Ackermans, Mariëtte T.; Endert, E.; Sauerwein, Hans P.

doi:10.1016/j.clnu.2004.01.008

Cited by 6 publications

(4 citation statements)

References 30 publications

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“…However, this is contradicted by a study in adults with uncomplicated malaria who were fasted for 22 hours. In these patients, the decrease in the rate of decline of glycogenolysis was slower than that in healthy controls despite a much lower rate of glycogenolysis in the malaria patients, indicating that the regulation of glycogenolysis in malaria is not dictated by glycogen content, but is driven by the necessity to maintain euglycemia [162]. This means that impaired glycogenolysis is unlikely to be a causative factor in the occurrence of hypoglycemia in malaria in adults.…”

Section: Glycogenolysis In Infectious Diseasementioning

confidence: 57%

Glucose metabolism in children: influence of age, fasting, and infectious diseases

et al. 2009

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Section: Glycogenolysis In Infectious Diseasementioning

confidence: 57%

Glucose metabolism in children: influence of age, fasting, and infectious diseases

et al. 2009

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“…Glycogenolysis shows a straight-line fall for the first 22 hours of fasting (30) while gluconeogenesis increases and becomes critical after 18–24 hours (31, 32). This suggests that adverse metabolic shifts may be minimized by aiming to hold total fasting periods fewer than 18 hours for ED patients.…”

Section: Discussionmentioning

confidence: 99%

Fasting Periods in Older Patients Attending a South London Emergency Department

McDonald

2013

Journal of Nutrition in Gerontology and Geriatrics

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There is increasing recognition of the deleterious effects of poor nutrition on health care outcomes. Older patients appear particularly vulnerable to the effects of undernutrition. This includes both low intake as patients and chronic preadmission undernutrition. This study investigates nutrition during a critical intervening period when patients present to a hospital emergency department (ED) in the first half of the day. One third of observed patients sustained periadmission fasts in excess of 18 hours. This fasting period showed significant positive correlation to age (correlation coefficient = 0.34, P < 0.05). Analysis of the results by gender showed that men who were older than the average cohort age of 53.6 years fasted for a significantly longer period in the hospital than their younger counterparts (P < 0.02). This comparison did not reach significant levels for female patients (P > 0.05). This study raises the question as to whether food should be routinely provided in the ED unless there is reason to withhold it. Particular care should be taken to avoid unnecessary delays in offering food to older patients. There may also be a need to ensure that geriatric care indicators are considered individually for each gender.

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“…Glucose production after 16 h of fasting was 15 % higher in malaria patients than in control and the relative decrease in glycogenolysis is independent of the absolute rate of glycogenolysis and the regulation of glycogenolysis during fasting seems not preferentially dictated by glycogen content but driven by the necessity to maintain glucose output and euglycemia (Sprangers et al, 2004). Histochemical effect presented in figure 2 (special staining with periodic acid-Schiff (PAS)) for glycogen store expression indicates that group A (placebo treated and infected) had moderate expression; group B had little or no PAS expression; group C had mild to moderate PAS expression; group D (treated with artemether/lumefantrine, then infected) had high PAS expression.…”

Section: Discussionmentioning

confidence: 99%

Nauclea latifolia Ethanolic Leaves Extract Moderately Hepatoprotects, but Decreases Periodic Acid-Schiff and Up-regulates Cytokeratin-7 Expression in Prophylaxis Malaria

Edagha¹,

Ndem²

2017

ijSciences

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Some herbal antiplasmodial plants have not been investigated for their hepatotoxic and glycogen lowering effects in experimental malaria models. We investigated the histochemical and immunohistochemical effects of ethanolic leaves extract of Nauclea latifolia (NL) an antiplasmodial plant on the liver of experimental prophylactic malaria mice. Twenty (20) mice (20-24 g) were grouped after acclimatization as follows: group A administered normal saline for 3 days, then inoculated with Plasmodium berghei (Pb); group B received 500 mg per kg body weight extract for 3 days then infected with Pb; group C received 1000 mg per weight extract for 3 days then infected with Pb; group D received 5 mg per kg body weight Artemether/lumefantrine (AL) for 3 days then infected with Pb. Extracts and drug were administered orally via oro-gavage needle. Inoculums of Pb at 1x10 6 were injected intraperitoneally and were subsequently monitored for 72 hrs, then fasted over night, and humanely sacrificed with liver tissues excised and processed for light microscopy. Result of routine hematoxylin and eosin stain in Figure 1 revealed that group A had the most heptocellular distortions and inflammation with prominent hyperplasia compared to extract and drug treated groups (groups B -D); in figure 2 periodic acid-Schiff (PAS) showed that group A had moderate PAS expression of glycogen stores; extract groups had depleted glycogen stores compared to group D -the AL group had more glycogen stores. In figure 3 the cytokeratin-7 showed that groups A -C had moderate positivity, while group D was mild/lower. In conclusion NL ethanolic leaf extract is moderately hepatoprotective in a dose dependent manner, but decreased periodic acid-Schiff (PAS) expression of glycogen granules and moderately up-regulated cytokeratin-7 in experimental prophylaxis malaria mice.

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Glycogenolysis during short-term fasting in malaria and healthy subjects?the potential regulatory role of glycogen content on glycogen breakdown: a hypothesis

Cited by 6 publications

References 30 publications

Glucose metabolism in children: influence of age, fasting, and infectious diseases

Glucose metabolism in children: influence of age, fasting, and infectious diseases

Fasting Periods in Older Patients Attending a South London Emergency Department

Nauclea latifolia Ethanolic Leaves Extract Moderately Hepatoprotects, but Decreases Periodic Acid-Schiff and Up-regulates Cytokeratin-7 Expression in Prophylaxis Malaria

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