Glycolic Acid Peels for Postinflammatory Hyperpigmentation in Black Patients

Burns, Robert L.; Prevost‐Blank, Paula L.; Lawry, Monica; Lawry, Todd B.; Faria, Duyen T.; Ftvenson, David P.

doi:10.1111/j.1524-4725.1997.tb00014.x

Cited by 97 publications

(78 citation statements)

References 11 publications

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“…Burns et al 22 assessed 19 patients (SPT IV-VI) with PIH who were randomized to either of two groups. The control group was managed with 2% hydroquinone/10% glycolic acid gel twice daily, with 0Á05% tretinoin at night.…”

Section: Glycolic Acid and Postinflammatory Hyperpigmentationmentioning

confidence: 99%

Chemical peeling in ethnic skin: an update

2013

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SummaryWith the growth of cosmetic dermatology worldwide, treatments that are effective against skin diseases and augment beauty without prolonged recovery periods, or exposing patients to the risks of surgery, are increasing in popularity. Chemical peels are a commonly used, fast, safe and effective clinic room treatment that may be used for cosmetic purposes, such as for fine lines and photoageing, but also as primary or adjunct therapies for acne, pigmentary disorders and scarring. Clinicians are faced with specific challenges when using peels on ethnic skin (skin of colour). The higher risk of postinflammatory dyschromias and abnormal scarring makes peels potentially disfiguring. Clinicians should therefore have a sound knowledge of the various peels available and their safety in ethnic skin. This article aims to review the background, classification, various preparations, indications, patient assessment and complications of using chemical peels in ethnic skin.What's already known about this topic?• Chemical peels are efficacious therapeutic interventions for many skin disorders.• Many peels exist; however, not all are safe for use in ethnic skin.• Darker skin types have an increased risk of adverse events from chemical peeling such as pigmentary disorders. What does this study add?• This is an up-to-date review of the various peeling agents and their indications for use in ethnic skin.• It provides a summary of newer peeling agents.• It gives practical tips on performing chemical peeling safely and effectively in ethnic skin.

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Section: Glycolic Acid and Postinflammatory Hyperpigmentationmentioning

confidence: 99%

Chemical peeling in ethnic skin: an update

2013

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“…Since Kligman et al [10] reported that the combined use of topical atRA, dexamethasone, and hydroquinone was more effective as a depigmenting formulation than a single use of each reagent, hydroquinone has been widely used in combination with atRA and corticosteroid [4,18]. Furthermore, in recent years, hydroquinone has been used in combination with laser therapies [1,2,8], dermabrasion [20], and chemical peelings such as Jessner's solution and glycolic acid [3,5,13,14]. Although Kligman's mixture is well-known and widely used, the bleaching ability is weak and a prolonged period of treatment is required, with variable clinical results.…”

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confidence: 99%

A New Bleaching Protocol for Hyperpigmented Skin Lesions with a High Concentration of All-trans Retinoic Acid Aqueous Gel

Harii¹,

Aoyama²,

Shibuya³

et al. 1999

Aesthetic Plastic Surgery

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Abstract.A new bleaching protocol for skin hyperpigmentation with a higher concentration of all-trans retinoic acid (atRA) aqueous gel than those commercially available is introduced. AtRA aqueous gel (0.1%) was applied topically twice a day along with 4% hydroquinone, 7% lactic acid ointment to oriental patients with hyperpigmented lesions such as senile lentigines, melasma, and postinflammatory hyperpigmentation. The clinical results of 39 patients treated with 0.1% atRA aqueous gel were compared to those of 22 patients treated with 0.1% atRA hydrophilic ointment. Better clinical results and subjective satisfaction were obtained through a significantly shorter period of treatment with 0.1% atRA aqueous gel than with 0.1% atRA hydrophilic ointment, although side effects such as erythema and irritation were seen at a higher frequency. It is suggested that our bleaching protocol with a high concentration of atRA aqueous gel in combination with hydroquinone and lactic acid has a strong bleaching ability and a potential as a standard therapy for various kinds of skin lesions with hyperpigmentation.

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“…In a number of previous studies [2,3,5,6,8], the L* value has been utilized as an index of skin pigmentation. However, there was only a weak correlation between the L* value and the melanin index detected in normal skin [7].…”

Section: Discussionmentioning

confidence: 99%

Usefulness of a Narrow-Band Reflectance Spectrophotometer in Evaluating Effects of Depigmenting Treatment

Yoshimura¹,

Harii²,

Masuda³

et al. 2001

Aesthetic Plastic Surgery

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Abstract. As a depigmenting treatment, combined topical applications of all-trans retinoic acid (atRA) aqueous gel and 5% hydroquinone, 7% lactic acid ointment were used for Oriental patients with hyperpigmented skin lesions such as senile lentigines and nevus spilus. A narrow-band reflectance spectrophotometer and a tristimulus colorimeter were used to evaluate objectively the intensity of pigmentation and erythema at each clinical visit. L*, a*, and b* values measured with a tristimulus colorimeter (Chroma Meter CR-300) enabled the evaluation of erythema but not pigmentation. On the other hand, the melanin and hemoglobin values measured with a narrow-band reflectance spectrophotometer (Mexameter MX-16) expressed both erythema and pigmentation well. It was revealed that, in our bleaching protocol, the narrow-band reflectance spectrophotometer was quite useful for estimating accurately the intensity of pigmentation and erythema and determining the best time point for the cessation of atRA treatment. Key words: Depigmenting treatment-Retinoic acid aqueous gel-Senile lentigines-Nevus spilusUsing our bleaching protocol with a high concentration of all-trans retinoic acid (atRA) aqueous gel in combination with hydroquinone and lactic acid, a remarkable improvement of various skin lesions with hyperpigmentation, such as senile lentigines [13], melasma, postinflammatory hyperpigmentation, and nevus spilus, was obtained with a short period of treatment [14]. However, during the treatment, side effects such as erythema were frequently observed after the topical application of atRA.Tristimulus colorimeters and full-range or narrowband spectrophotometers have been employed for the quantification of erythema and pigmentation induced by ultraviolet radiation (UVR) [7], and for the color analysis of skin lesions [9] or transferred skin [12]. We have used a tristimulus colorimeter and a narrow-band spectrophotometer to evaluate skin reactions such as the intensity of pigmentation and erythema in our bleaching treatment. Representative cases are demonstrated and the usefulness of the reflectance spectrophotometer is discussed. MethodsCombined topical applications of atRA, hydroquinone, and lactic acid were used for skin lesions with hyperpigmentation. atRA aqueous gel (atRA gel; 0.1, 0.2, and 0.4%) was originally prepared at the Department of Pharmacy, University of Tokyo. AtRA gel was topically applied together with 5% hydroquinone, 7% lactic acid ointment (HQ-LA ointment), also prepared as described above. Plastibase (petrolatum polyethylene ointment base; Taisho Pharmacology, Osaka, Japan) was used as the ointment base of HQ-LA ointment. Both atRA gel and HQ-LA ointments are pharmacologically unstable, so that fresh ointments were prepared at least once a month. Each ointment was topically applied under signed informed consent to more than 120 Oriental patients with hyperpigmented skin lesions such as sinile lentigines, melasma, postinflammatory hyperpigmentation, and nevus spilus.Treatment protocol. atRA gel was applied to...

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Glycolic Acid Peels for Postinflammatory Hyperpigmentation in Black Patients

Abstract: This pilot study demonstrates that serial glycolic acid peels provide an additional benefit, with minimal adverse effects, for the treatment of postinflammatory hyperpigmentation in dark-complexioned individuals.

Cited by 97 publications

References 11 publications

Chemical peeling in ethnic skin: an update

Chemical peeling in ethnic skin: an update

A New Bleaching Protocol for Hyperpigmented Skin Lesions with a High Concentration of All-trans Retinoic Acid Aqueous Gel

Usefulness of a Narrow-Band Reflectance Spectrophotometer in Evaluating Effects of Depigmenting Treatment

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