Glycolic Acid Peels in the Treatment of Melasma among Asian Women

Lim, Jinkang; Tham, S N

doi:10.1111/j.1524-4725.1997.tb00016.x

Cited by 92 publications

(70 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Sarkar et al (2002) have demonstrated that serial glycolic acid peels can significantly improve the clinical efficacy of a modified Kligman's formula. Improvement of pigmented spots has been observed in Asian women treated with daily application of 10% glycolic acid and 2% hydroquinone in association with 70% glycolic acid peels every 3 weeks (Lim and Than, 1997).…”

Section: Combination Therapiesmentioning

confidence: 96%

Hypopigmenting agents: an updated review on biological, chemical and clinical aspects

Solano¹,

Briganti²,

Picardo³

et al. 2006

Pigment Cell Research

620

524

View full text Add to dashboard Cite

SummaryAn overview of agents causing hypopigmentation in human skin is presented. The review is organized to put forward groups of biological and chemical agents. Their mechanisms of action cover (i) tyrosinase inhibition, maturation and enhancement of its degradation; (ii) Mitf inhibition; (iii) downregulation of MC1R activity; (iv) interference with melanosome maturation and transfer; (v) melanocyte loss, desquamation and chemical peeling. Tyrosinase inhibition is the most common approach to achieve skin hypopigmentation as this enzyme catalyses the rate-limiting step of pigmentation. Despite the large number of tyrosinase inhibitors in vitro, only a few are able to induce effects in clinical trials. The gap between in-vitro and in-vivo studies suggests that innovative strategies are needed for validating their efficacy and safety. Successful treatments need the combination of two or more agents acting on different mechanisms to achieve a synergistic effect. In addition to tyrosinase inhibition, other parameters related to cytotoxicity, solubility, cutaneous absorption, penetration and stability of the agents should be considered. The screening test system is also very important as keratinocytes play an active role in modulating melanogenesis within melanocytes. Mammalian skin or at least keratinocytes/melanocytes co-cultures should be preferred rather than pure melanocyte cultures or soluble tyrosinase.

show abstract

Section: Combination Therapiesmentioning

confidence: 96%

Hypopigmenting agents: an updated review on biological, chemical and clinical aspects

Solano¹,

Briganti²,

Picardo³

et al. 2006

Pigment Cell Research

620

524

View full text Add to dashboard Cite

show abstract

“…Glycolic acid (GA) peel, an AHA, has been widely used for pigmentary dyschromias and acne, [3][4][5][6][7][8] but few studies have evaluated GA peels in dark skins, including Asian patients. 9 Salicylic-mandelic acid peel (SMP) is a newer combination peel that combines the properties of a BHA and an AHA.…”

mentioning

confidence: 99%

Glycolic Acid Peels Versus Salicylic-Mandelic Acid Peels in Active Acne Vulgaris and Post-Acne Scarring and Hyperpigmentation: A Comparative Study

Garg¹,

Sinha²,

Sarkar³

2009

Dermatologic Surgery

View full text Add to dashboard Cite

show abstract

“…Since Kligman et al [10] reported that the combined use of topical atRA, dexamethasone, and hydroquinone was more effective as a depigmenting formulation than a single use of each reagent, hydroquinone has been widely used in combination with atRA and corticosteroid [4,18]. Furthermore, in recent years, hydroquinone has been used in combination with laser therapies [1,2,8], dermabrasion [20], and chemical peelings such as Jessner's solution and glycolic acid [3,5,13,14]. Although Kligman's mixture is well-known and widely used, the bleaching ability is weak and a prolonged period of treatment is required, with variable clinical results.…”

mentioning

confidence: 99%

A New Bleaching Protocol for Hyperpigmented Skin Lesions with a High Concentration of All-trans Retinoic Acid Aqueous Gel

Harii¹,

Aoyama²,

Shibuya³

et al. 1999

Aesthetic Plastic Surgery

View full text Add to dashboard Cite

Abstract.A new bleaching protocol for skin hyperpigmentation with a higher concentration of all-trans retinoic acid (atRA) aqueous gel than those commercially available is introduced. AtRA aqueous gel (0.1%) was applied topically twice a day along with 4% hydroquinone, 7% lactic acid ointment to oriental patients with hyperpigmented lesions such as senile lentigines, melasma, and postinflammatory hyperpigmentation. The clinical results of 39 patients treated with 0.1% atRA aqueous gel were compared to those of 22 patients treated with 0.1% atRA hydrophilic ointment. Better clinical results and subjective satisfaction were obtained through a significantly shorter period of treatment with 0.1% atRA aqueous gel than with 0.1% atRA hydrophilic ointment, although side effects such as erythema and irritation were seen at a higher frequency. It is suggested that our bleaching protocol with a high concentration of atRA aqueous gel in combination with hydroquinone and lactic acid has a strong bleaching ability and a potential as a standard therapy for various kinds of skin lesions with hyperpigmentation.

show abstract

Glycolic Acid Peels in the Treatment of Melasma among Asian Women

Cited by 92 publications

References 3 publications

Hypopigmenting agents: an updated review on biological, chemical and clinical aspects

Hypopigmenting agents: an updated review on biological, chemical and clinical aspects

Glycolic Acid Peels Versus Salicylic-Mandelic Acid Peels in Active Acne Vulgaris and Post-Acne Scarring and Hyperpigmentation: A Comparative Study

A New Bleaching Protocol for Hyperpigmented Skin Lesions with a High Concentration of All-trans Retinoic Acid Aqueous Gel

Contact Info

Product

Resources

About