Glycolic Acid Therapy: Evaluation of Efficacy and Techniques in Treatment of Photodamage Lesions

Moy, Lawrence S.; Murad, Howard; Moy, Ronald L.

doi:10.1177/074880689301000103

Cited by 18 publications

(5 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 33 For example, one questionnaire found that patients receiving topical glycolic acid, who had previously received topical tretinoin preferred treatment with glycolic acid. 26 …”

Section: Discussionmentioning

confidence: 99%

An antiaging skin care system containing alpha hydroxy acids and vitamins improves the biomechanical parameters of facial skin

Tran¹,

Townley²,

Barnes³

et al. 2014

CCID

View full text Add to dashboard Cite

BackgroundThe demand for antiaging products has dramatically increased in recent years, driven by an aging population seeking to maintain the appearance of youth. This study investigates the effects of an antiaging skin care system containing alpha hydroxy acids (AHAs) in conjunction with vitamins B3, C, and E on the biomechanical parameters of facial skin.MethodsFifty two volunteers followed an antiaging skin care regimen comprising of cleanser, eye cream, day moisturizer, and night moisturizer for 21 days. Wrinkle depth (Ry) and skin roughness (Ra) were measured by skin surface profilometry of the crow’s feet area, and skin elasticity parameters R2 (gross elasticity), R5 (net elasticity), R6 (viscoelastic portion), and R7 (recovery after deformation) were determined for facial skin by cutometer, preapplication and after 7, 14, and 21 days. Volunteers also completed a self-assessment questionnaire.ResultsCompared to baseline, Ry and Ra significantly improved by 32.5% (P<0.0001) and 42.9% (P<0.0001), respectively, after 21 days of antiaging skin care treatment. These results were observed by the volunteers with 9 out of 10 discerning an improvement in skin texture and smoothness. Compared to baseline, R2 and R5 significantly increased by 15.2% (P<0.0001) and 12.5% (P=0.0449), respectively, while R6 significantly decreased by 17.7% (P<0.0001) after 21 days. R7 increased by 9.7% after 21 days compared to baseline but this was not significant over this time period.ConclusionAn antiaging skin care system containing AHAs and vitamins significantly improves the biomechanical parameters of the skin including wrinkles and skin texture, as well as elasticity without significant adverse effects.

show abstract

“… 33 For example, one questionnaire found that patients receiving topical glycolic acid, who had previously received topical tretinoin preferred treatment with glycolic acid. 26 …”

Section: Discussionmentioning

confidence: 99%

An antiaging skin care system containing alpha hydroxy acids and vitamins improves the biomechanical parameters of facial skin

Tran¹,

Townley²,

Barnes³

et al. 2014

CCID

View full text Add to dashboard Cite

show abstract

“…[The large gains in effective signal and signal-to-background are also allowing some successful work to be performed on laboratory sources (Akahama, Kobayashi & Kawamura, 1993).] Further possibilities are in view with the development of different two-dimensional detectors offering real-time readout, and with the large gains in brilliance that will come from third-generation sources (Moy, 1993;Hiiusermann, 1993). Amongst other things, it should be possible to reach considerably higher pressures, study more weakly scattering materials, follow transition processes, and extend the techniques to liquid and amorphous samples.…”

Section: Discussionmentioning

confidence: 99%

High-Pressure Powder Diffraction on Synchrotron Sources

Nelmes¹,

McMahon²

1994

J Synchrotron Radiat

108

View full text Add to dashboard Cite

The sample volume in diamond-anvil pressure cells suitable for X-ray powder diffraction studies is very small (_<1001am across). The resulting low signal-to-noise ratio has made it very difficult to obtain useful results with monochromatic angle-dispersive techniques, and the alternative whitebeam energy-dispersive techniques have limited resolution and generally give unreliable peak intensities. The situation has been transformed recently by the introduction of the image-plate twodimensional detector, which allows angle-dispersive methods to be used with a greatly increased signal and improved powder averaging. A short review is given of this development, the experimental techniques, and the principal advantages, particularly as found in results obtained at SRS Daresbury over the past two or three years.

show abstract

“…In contrast to the all-or-none response to phenol, a varied response accord ing to concentration can be obtained with tri chloroacetic acid peels [48.49], Superficial peeling (stratum corneum or epidermal peeling) can be accomplished with AHAs, such as glycolic acid, lactic acid and pyruvic acid, at concentrations about 10-fold greater than those used as plasticizers for skin softening. Concentrations of 50-85% are used, either as aqueous or ethanolic solutions [50], In an uncontrolled, preliminary study, improvements were noted in overall appear ance, texture, fine wrinkling and pigmenta tion with mild glycolic acid peels, but changes Skin Pharmacol 1997; 10:1 -1!in coarse wrinkling were modest [51]. Most data are available on glycolic and lactic acids, but there are many other AHAs and [3 hy droxy acids (tropic acid, for example) that have activity but have not been studied in detail.…”

Section: Photodamage Treatment Optionsmentioning

confidence: 99%

Treatment Options for Photodamaged Skin

Griffiths¹

1997

Skin Pharmacol Physiol

View full text Add to dashboard Cite

Photodamage of the skin can be a detriment to physical and psychological health with a consequent negative impact on both personal and professional life. Medical treatments for photodamaged skin include topical all-trans-retinoic acid (tretinoin) as well as moisturizers, chemical peels, dermabrasion, Α hydroxy acids and cosmetic surgery. Of these treatment options, only tretinoin has been subjected to large-scale, controlled studies to substantiate its clinical efficacy and long-term benefits. This review summarizes the use of various therapies and presents available clinical and histologic results of systematic trials, including the few studies of retinoid compounds other than tretinoin. Among the extensive data on topical tretinoin are long-term treatment results that provide evidence of ultrastructural changes. These histologic findings suggest that fundamental cellular effects may be responsible for the clinical benefits, which are sustained even when treatment frequency is reduced. It thus appears that tretinoin therapy at least partially restores photodamaged skin to the predamaged state.

show abstract

Glycolic Acid Therapy: Evaluation of Efficacy and Techniques in Treatment of Photodamage Lesions

Cited by 18 publications

References 1 publication

An antiaging skin care system containing alpha hydroxy acids and vitamins improves the biomechanical parameters of facial skin

An antiaging skin care system containing alpha hydroxy acids and vitamins improves the biomechanical parameters of facial skin

High-Pressure Powder Diffraction on Synchrotron Sources

Treatment Options for Photodamaged Skin

Contact Info

Product

Resources

About