Glycolysis abnormalities in fibromyalgia.

Abstract

These findings provide support that FM is associated with biochemical abnormalities which require appropriate metabolic therapy.

ATP, calcium and magnesium levels in platelets of patients with primary fibromyalgia

“…In a previous work, [Ca 2+ ] i and [Mg 2+ ] i have been found reduced in polymorphonuclear cells of patients with FMs [27]. A possible explanation to this contradiction could be that diverse adaptive mechanisms and dynamics for controlling Mg 2+ and Ca 2+ levels exist among the different blood differentiation cell lines and/or that different methodologies were used [38]. Thus, the present and past results may define, more generally, a diminished homeostatic capacity in affected subjects to regulate ATP, Ca 2+ and Mg 2+ cell pathways/fluxes within or outside cells.…”

“…Primarily, a reduction of intracellular ATP levels, the final product of glucose catabolism, suggests an imbalance between ATP synthesis-consumption inside platelets of FM subjects. Perturbations of glucose metabolism have been previously detected in patients affected by FMs: reduced serum levels of growth hormone (GH), lactate dehydrogenase (LDH) muscular iso-enzyme 4 (H1M3), decreased concentrations of ATP inside erythrocytes and hyperpyruvicemia [38], together with increased levels of insulin [39] have been observed in normoglycemic patients as regards to controls. Reciprocally, FM symptoms have been found in association to metabolic syndrome in women [40].…”

Evidence for metabolic abnormalities in the muscles of patients with fibromyalgia

“…The reduced levels of ATP and PCr in the patients' muscles correlated inversely with clinical observations of weakness or pain as measured on a visual analog scale (VAS) [40]. Reduction of ATP in erythrocytes of patients with FM has been observed, suggesting that this may be a more general systemic phenomenon than previously thought [41,42]. All metabolic abnormalities in the muscles of patients with FM were less severe than those previously reported for very weak subjects with dermatomyositis [38].…”

The history and definition of fibromyalgia

“…Current research and clinical consensus seem to indicate that FMS is not primarily a musculoskeletal problem, although it is in the tissues of this system that its major symptoms manifest: 'Fibromyalgia is a chronic, painful, musculo-skeletal condition characterised by widespread aching and points of tenderness associated with: 1) changed perception of pain, abnormal sleep patterns and reduced brain serotonin; and 2) abnormalities of microcirculation and energy metabolism in muscle' (Eisinger et al 1994).…”