Glycomacromolecules: Addressing challenges in drug delivery and therapeutic development

Stuart-Walker, Will; Mahon, Clare S.

doi:10.1016/j.addr.2021.01.018

Cited by 8 publications

(3 citation statements)

References 203 publications

(219 reference statements)

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“…While passively targeted drug delivery to tumor cells can be achieved by exploiting the enhanced permeability and retention (EPR) effect, , nanocarriers with targeting functionalities offer a versatile way to deliver cargo to a specific cell type expressing the corresponding receptors. Targeting can be mediated by either nanoparticle size or ligands for selective recognition such as antibodies, , folic acid, , biotin, , peptides, , hormones, , and carbohydrates …”

Section: Applicationsmentioning

confidence: 99%

“…Targeting can be mediated by either nanoparticle size 172 or ligands for selective recognition such as antibod- ies, 173,174 folic acid, 175,176 biotin, 177,178 peptides, 179,180 hormones, 181,182 and carbohydrates. 183 Glycosylated ligands are utilized in targeted delivery systems because of the highly specific interaction between carbohydrates and their lectin counterparts. Lectins are carbohydratebinding proteins, ubiquitously involved in cellular recognition or the onset of viral and bacterial infections.…”

Section: Polymeric Glyconanoparticlesmentioning

confidence: 99%

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Hierarchy of Complex Glycomacromolecules: From Controlled Topologies to Biomedical Applications

et al. 2022

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Carbohydrates bearing a distinct complexity use a special code (Glycocode) to communicate with carbohydrate-binding proteins at a high precision to manipulate biological activities in complex biological environments. The level of complexity in carbohydrate-containing macromolecules controls the amount and specificity of information that can be stored in biomacromolecules. Therefore, a better understanding of the glycocode is crucial to open new areas of biomedical applications by controlling or manipulating the interaction between immune cells and pathogens in terms of trafficking and signaling, which would become a powerful tool to prevent infectious diseases. Even though a certain level of progress has been achieved over the past decade, synthetic glycomacromolecules are still lagging far behind naturally existing glycans in terms of complexity and precision because of insufficient and inefficient synthetic techniques. Currently, specific targeting at a cellular level using synthetic glycomacromolecules is still challenging. It is obvious that multidisciplinary collaborations are essential between different specialized disciplines to enhance the carbohydrate receptor-targeting paradigm for new biomedical applications. In this Perspective, recent developments in the synthesis of sophisticated glycomacromolecules are highlighted, and their biological and biomedical applications are also discussed in detail.

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Section: Applicationsmentioning

confidence: 99%

Section: Polymeric Glyconanoparticlesmentioning

confidence: 99%

Hierarchy of Complex Glycomacromolecules: From Controlled Topologies to Biomedical Applications

et al. 2022

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“…The high affinity in recognition processes is crucial for biological systems to generate specific functions in complex and uncertain environments. − However, as described by Kim and co-workers, those natural high-affinity pairs can hardly be dissociated under mild condition and can be easily affected by biological systems, thus limiting their wide application . Therefore, artificial host–guest systems with high affinity and selectivity in aqueous solution have attracted the attention of researchers.…”

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confidence: 99%

A High-Affinity and Removable Iminium Dication Guest for Recycling of Cucurbit[7]uril Materials

Liu

2022

Org. Lett.

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An iminium dication 1 was designed as a high-affinity and easily removable guest for cucurbit[7]uril (CB[7]). X-ray crystallographic analysis shows that maximized N + •••O�C ion− dipole interactions and perfect packing coefficient are responsible for the high affinity of 1 for CB[7] (K a > 10 11 M −1 ). Under alkaline conditions, included 1 in CB[7]•1 is hydrolyzed into 2,6adamantanedione and pyrrolidine that can be fully removed by further extraction, enabling the recycling of CB[7] materials.

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Applications of molecular pharmacology in drug discovery

Kesh,

Biswas

2024

Biochemical and Molecular Pharmacology in Drug Discovery

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Glycomacromolecules: Addressing challenges in drug delivery and therapeutic development

Cited by 8 publications

References 203 publications

Hierarchy of Complex Glycomacromolecules: From Controlled Topologies to Biomedical Applications

Hierarchy of Complex Glycomacromolecules: From Controlled Topologies to Biomedical Applications

A High-Affinity and Removable Iminium Dication Guest for Recycling of Cucurbit[7]uril Materials

Applications of molecular pharmacology in drug discovery

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