Glycome assessment in patients with respiratory diseases

Shipunov, Ivan; Купаев, В. И.

doi:10.1016/j.tmsr.2022.02.001

Cited by 1 publication

(5 citation statements)

References 63 publications

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“… 2013 ;Jia et al. 2020 ; Shipunov and Kupaev 2022 ). Nonetheless, information is scant for livestock.…”

Section: Discussionmentioning

confidence: 99%

“… 2017 ). The ensemble of glycan forms found in mucins and their arrangements, particularly within glycoproteins, comprise the glycome (Kunej 2019 ; Shipunov and Kupaev 2022 ). The study of the glycome, the so-called glycomics, is metaphorically akin to forestry; each glycoprotein contains glycans (leaves) conjugated to a protein (tree trunk) (Critcher et al.…”

Section: Discussionmentioning

confidence: 99%

“…Beyond mucin expression alterations, glycan glycosylation patterns have also been linked to respiratory physiopathology (Hoffman et al. 2020 ; Shipunov and Kupaev 2022 ). During inflammation, mucin glycans exhibit reduced chain length, sulfation, fucosylation, and increased sialylation (Schulz et al.…”

Section: Discussionmentioning

confidence: 99%

“…Mucins have a high molecular weight and are made of glycosylated proteins with hundreds of branching chain carbohydrates ( O -linked glycans). The carbohydrate structures found in mucins and their arrangements, particularly within glycoproteins, comprise the glycome (Kunej 2019 , Shipunov and Kupaev 2022 ).…”

Section: Introductionmentioning

confidence: 99%

“…The vast diversity of mucin glycome patterns makes them ideal for encoding biological information with a higher specificity (Shipunov and Kupaev 2022 ). First, they provide a physical and chemical barrier that traps and clears inhaled particles and neutralizes toxins, allergens, pollutants, and pathogens (Rose and Voynow 2006 ; Schnaar 2015 ; Atanasova and Reznikov 2019 ; Reily et al.…”

Section: Introductionmentioning

confidence: 99%

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The forecasting power of the mucin-microbiome interplay in livestock respiratory diseases

Mach

2024

Veterinary Quarterly

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Complex respiratory diseases are a significant challenge for the livestock industry worldwide. These diseases considerably impact animal health and welfare and cause severe economic losses. One of the first lines of pathogen defense combines the respiratory tract mucus, a highly viscous material primarily composed of mucins, and a thriving multi-kingdom microbial ecosystem. The microbiome-mucin interplay protects from unwanted substances and organisms, but its dysfunction may enable pathogenic infections and the onset of respiratory disease. Emerging evidence also shows that noncoding regulatory RNAs might modulate the structure and function of the microbiome-mucin relationship. This opinion paper unearths the current understanding of the triangular relationship between mucins, the microbiome, and noncoding RNAs in the context of respiratory infections in animals of veterinary interest. There is a need to look at these molecular underpinnings that dictate distinct health and disease outcomes to implement effective prevention, surveillance, and timely intervention strategies tailored to the different epidemiological contexts.

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“… 2013 ;Jia et al. 2020 ; Shipunov and Kupaev 2022 ). Nonetheless, information is scant for livestock.…”

Section: Discussionmentioning

confidence: 99%