2021
DOI: 10.3390/diagnostics11040643
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Glycomic-Based Biomarkers for Ovarian Cancer: Advances and Challenges

Abstract: Ovarian cancer remains one of the most common causes of death among gynecological malignancies afflicting women worldwide. Among the gynecological cancers, cervical and endometrial cancers confer the greatest burden to the developing and the developed world, respectively; however, the overall survival rates for patients with ovarian cancer are worse than the two aforementioned. The majority of patients with ovarian cancer are diagnosed at an advanced stage when cancer has metastasized to different body sites a… Show more

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Cited by 21 publications
(12 citation statements)
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References 99 publications
(91 reference statements)
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“…Glycoproteomics-based signatures can be used for tumor subtyping and clinical outcome prediction in ovarian cancer and provide potential for precision medicine [134]. Zhang's group first performed an integrated proteomic and glycoproteomic analysis of 83 high-grade serous ovarian carcinoma (HGSC) tumors and 23 non-tumors, which revealed tumor-specific glycosylation, uncovered different glycosylations associated with three tumor clusters and identified glycosylation enzymes correlated with glycosylation alterations [3].…”
Section: Cancers and Other Diseasesmentioning
confidence: 99%
“…Glycoproteomics-based signatures can be used for tumor subtyping and clinical outcome prediction in ovarian cancer and provide potential for precision medicine [134]. Zhang's group first performed an integrated proteomic and glycoproteomic analysis of 83 high-grade serous ovarian carcinoma (HGSC) tumors and 23 non-tumors, which revealed tumor-specific glycosylation, uncovered different glycosylations associated with three tumor clusters and identified glycosylation enzymes correlated with glycosylation alterations [3].…”
Section: Cancers and Other Diseasesmentioning
confidence: 99%
“…ROMA is a multivariable screening test authorized by the FDA in 2011 for predicting the risk of ovarian malignancy . ROMA incorporates HE4 and CA125 biomarkers.…”
Section: Progress In the Panel Of Protein Biomarkers And Algorithmsmentioning
confidence: 99%
“…Glycosylation, the addition of carbohydrate molecules, is a significant post-translational modification (PTM) to specific amino acid residues. Glycoproteins have critical functions in various biological processes, such as receptor interactions, cell communication, fertilization, immune defense, and inflammation. In particular, aberrantly glycosylated proteins are linked to cancer progression, including hepatocellular carcinoma (HCC). , Thus, it is important to develop an efficient quantitative method that is based on protein glycoforms.…”
Section: Introductionmentioning
confidence: 99%