Glycomics

Wilson, Iain B. H.

doi:10.1007/978-3-7091-1416-2_3

Cited by 2 publications

(1 citation statement)

References 74 publications

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“…This can be solved by making molecular ions more energetic by inducing fragmentation, which can be achieved by employing tandem MS [129,152]. Among the existing fragmentation techniques, collision-induced dissociation (CID) is employed for the generation of tandem mass spectra of oligosaccharides [185], in which analyte molecules are accelerated and collided with a neutral gas, resulting in the fragmentation of molecular bonds and the creation of tandem mass spectra [186]. Dissociation of protonated glycan or glycopeptides ions is not recommended because monosaccharide rearrangements may result.…”

Section: Ms Fragmentation Methodsmentioning

confidence: 99%

Glycosylation Biomarkers Associated with Age-Related Diseases and Current Methods for Glycan Analysis

Paton

Suárez

Herrero

et al. 2021

IJMS

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Ageing is a complex process which implies the accumulation of molecular, cellular and organ damage, leading to an increased vulnerability to disease. In Western societies, the increase in the elderly population, which is accompanied by ageing-associated pathologies such as cardiovascular and mental diseases, is becoming an increasing economic and social burden for governments. In order to prevent, treat and determine which subjects are more likely to develop these age-related diseases, predictive biomarkers are required. In this sense, some studies suggest that glycans have a potential role as disease biomarkers, as they modify the functions of proteins and take part in intra- and intercellular biological processes. As the glycome reflects the real-time status of these interactions, its characterisation can provide potential diagnostic and prognostic biomarkers for multifactorial diseases. This review gathers the alterations in protein glycosylation profiles that are associated with ageing and age-related diseases, such as cancer, type 2 diabetes mellitus, metabolic syndrome and several chronic inflammatory diseases. Furthermore, the review includes the available techniques for the determination and characterisation of glycans, such as liquid chromatography, electrophoresis, nuclear magnetic resonance and mass spectrometry.

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Section: Ms Fragmentation Methodsmentioning

confidence: 99%

Glycosylation Biomarkers Associated with Age-Related Diseases and Current Methods for Glycan Analysis

Paton

Suárez

Herrero

et al. 2021

IJMS

View full text Add to dashboard Cite

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Systems Glycobiology: Past, Present, and Future

Yıldız¹

2020

Computational Biology and Chemistry

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Glycobiology is a glycan-based field of study that focuses on the structure, function, and biology of carbohydrates, and glycomics is a sub-study of the field of glycobiology that aims to define structure/function of glycans in living organisms. With the popularity of the glycobiology and glycomics, application of computational modeling expanded in the scientific area of glycobiology over the last decades. The recent availability of progressive Wet-Lab methods in the field of glycobiology and glycomics is promising for the impact of systems biology on the research area of the glycome, an emerging field that is termed “systems glycobiology.” This chapter will summarize the up-to-date leading edge in the use of bioinformatics tools in the field of glycobiology. The chapter provides basic knowledge both for glycobiologists interested in the application of bioinformatics tools and scientists of computational biology interested in studying the glycome.

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Glycomics

Cited by 2 publications

References 74 publications

Glycosylation Biomarkers Associated with Age-Related Diseases and Current Methods for Glycan Analysis

Glycosylation Biomarkers Associated with Age-Related Diseases and Current Methods for Glycan Analysis

Systems Glycobiology: Past, Present, and Future

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