Glycopeptide dendrimers, Part III—a review: Use of glycopeptide dendrimers in immunotherapy and diagnosis of cancer and viral diseases

Abstract

Glycopeptide dendrimers containing different types of tumor associated-carbohydrate antigens (T(N), TF, sialyl-T(N), sialyl-TF, sialyl-Le(x), sialyl-Le(a) etc.) were used in diagnosis and therapy of different sorts of cancer. These dendrimeric structures with incorporated T-cell epitopes and adjuvants can be used as antitumor vaccines. Best results were obtained with multiantigenic vaccines, containing, e.g. five or six different TAAs. The topic of TAAs and their dendrimeric forms at molecular level are reviewed, including structure, syntheses, and biological activities. Use of glycopeptide dendrimers as antiviral vaccines against HIV and influenza is also described. Their syntheses, physico-chemical properties, and biological activities are given with many examples.

Dendrimers for theranostic applications

“…Several other dendrimers, such as poly(propyleneimine) (PPI) and poly(l-glutamic acid), have also been studied for their role in drug delivery (24). The glycopeptide dendrimers have been used in antitumor and antiviral prophylactic or therapeutic vaccines (25). Dendrimers with a polyhedral oligomeric silsesquioxane (POSS) core have been used for biomedical applications.…”

New-generation biomedical materials: Peptide dendrimers and their application in biomedicine

“…Various classes of these compounds differing in composition and structures were reported, together with their practical use extending from targeting drug delivery, catalysis, and transport vehicles to synthetic vaccines. The main stress was given to glycopeptide dendrimers, namely multiple antigen glycopeptides (MAGs) [55][56][57][58]. An example of glycopeptide dendrimer synthesis, where lactose ligands were introduced to the surface of lysine-based dendrimer, was reported by Uryu et al ( Figure 11) [59].…”

Multivalent glycoconjugates in medicinal chemistry

“…In the last few years there has been an impressive development of the design of synthetic multi-component MUC1-based glycopeptide vaccines. [51][52][53][54][55][56][57][58][59] These vaccines rely on mimicking the natural presentation of TACAs, typically found in clusters, for generating strong antibody responses and immunogenicity. 60,61 In this context, glycodendrimers have shown to be useful in vaccine preparation, due to their immunostimulating properties.…”