Glycopeptide-resistant Staphylococcus aureus

Johnson, A. P.

doi:10.1093/jac/dkf244

Cited by 23 publications

(7 citation statements)

References 17 publications

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“…isolates, but recent reports of resistance to these agents raise real concerns over how long these uniform susceptibilities will hold good. 4,5 This has led to renewed interest in the usage of macrolide (e.g., erythromycin)-lincosamide (e.g., Clindamycin)-streptogramin B (e.g., quinupristindalfopristin) (collectively called as MLSB family) antibiotics to treat Staphylococcus aureus (S. aureus) infections with, clindamycin being the preferred agent due to its excellent pharmacokinetic properties. Staphylococcal strains resistant to MLSB antibiotics have increased in number following the widespread use of these antibiotics for treating serious staphylococcal infections.…”

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confidence: 99%

Prevalence of inducible clindamycin resistance in erythromycin resistant clinical isolates of Staphylococcus aureus and CONS at tertiary care hospital

Thapa

Sapkota

2016

J Coll Med Sci-Nepal

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Background & Objectives: The objective of this study was to isolate and identify Staphylococcus species from different samples clinical samples and to determine the current trend regarding the incidence and distribution of inducible clindamycin resistance in clinical isolates of Staphylococcus aureus and CONS.Materials & Methods: A total of 264 isolates of staphylococcus species were isolated from various clinical samples. Clinical samples were cultured and Staphylococcus species were identified using standard microbiological methods recommended by the American Society for Microbiology (ASM). Methicillin resistance was confirmed using cefoxitin and oxacillin disks. Inducible clindamycin resistance was identified using D-zone test.Results: Among 264 erythromycin resistant staphylococcus species, 213 (80.6%) were S. aureus and 51 (19.3%) were CONS. Out of 213 erythromycin resistant isolates of S. aureus, 140 (65.7%) were MRSA and 73 (34.2%) were MSSA whereas out of 51 erythromycin resistant isolates of CONS, 28 (54.9%) were MRCNS and 23 (45%) were MSCNS. Constitutive MLSB phenotype and Inducible MLSB phenotype was higher among both MRSA and MRCNS isolates. MS phenotype was more predominant among 11 (5.1%) MSSA and 5 (9.8%) MSCNS isolates compared to 9 (4.2%) in MRSA and 2 (3.9%) in MRCNS.Conclusion: The prevalence of constitutive & inducible clindamycin resistance in staphylococcus isolates was high among both MRSA and MRCNS. Hence the implementation of D-test routinely, will reveal the iMLSB & cMLSB phenotype & will guide the clinicians whether to use clindamycin in staphylococcal infections when erythromycin resistance is present.

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confidence: 99%

Prevalence of inducible clindamycin resistance in erythromycin resistant clinical isolates of Staphylococcus aureus and CONS at tertiary care hospital

Thapa

Sapkota

2016

J Coll Med Sci-Nepal

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“…There is also an increasing incidence of community-acquired MRSA, and concern over community-acquired MRSA has led to much current research (28). Some strains of MRSA (fortunately still a minority) can also be resistant to teicoplanin and vancomycin, and the rate at which S. aureus can develop or acquire resistance to new antibiotics seems to be higher than the rate at which new antibiotics are discovered and developed (9,19). Thus, it is essential that new approaches to preventing, controlling, and treating infections due to MRSA be developed.…”

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confidence: 99%

Development of a Novel Targeting System for Lethal Photosensitization of Antibiotic-Resistant Strains of Staphylococcus aureus

Embleton

Nair

Heywood

et al. 2005

Antimicrob Agents Chemother

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Light-activated antimicrobial agents (photosensitizers) are promising alternatives to antibiotics for the treatment of topical infections. To improve efficacy and avoid possible damage to host tissues, targeting of the photosensitizer to the infecting organism is desirable, and this has previously been achieved using antibodies and chemical modification of the agent. In this study we investigated the possibility of using a bacteriophage to deliver the photosensitizer tin(IV) chlorin e6 (SnCe6) to Staphylococcus aureus. SnCe6 was covalently linked to S. aureus bacteriophage 75, and the ability of the conjugate to kill various strains of S. aureus when exposed to red light was determined. Substantial kills of methicillin-and vancomycin-intermediate strains of S. aureus were achieved using low concentrations of the conjugate (containing 1.5 g/ml SnCe6) and low light doses (21 J/cm 2 ). Under these conditions, the viability of human epithelial cells (in the absence of bacteria) was largely unaffected. On a molar equivalent basis, the conjugate was a more effective bactericide than the unconjugated SnCe6, and killing was not growth phase dependent. The conjugate was effective against vancomycin-intermediate strains of S. aureus even after growth in vancomycin. The results of this study have demonstrated that a bacteriophage can be used to deliver a photosensitizer to a target organism, resulting in enhanced and selective killing of the organism. Such attributes are desirable in an agent to be used in the photodynamic therapy of infectious diseases.

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“…This resistance was attributed to the frequent use of antibiotic by patient themselves and sometimes practitioners as well. Which lead the bacteria to become extreme drug resistance 21,22 .…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Antibiotic Resistant Bacteria among the Clinical Samples from Different Hospitals of Peshawar, Pakistan

Khan¹,

Khan²,

Ahmad³

et al. 2022

PJMHS

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Background: Majority of the microorganisms are responsible for causing diseases which can be fatal if left untreated. In Pakistan this might be very critical because of the misuse and/or improper use of antibiotics. Objective: The current study was designed to point out the challenges of antibiotic resistance in Peshawar Pakistan. Methods: A total of 100 samples, 25 each from blood, pus, skin, urine were collected from four different hospitals of Peshawar, Pakistan. The samples were grown on culture media after collection. Results: Out 100 samples, 46 samples showed growth on culture medium. Four main isolates namely Staphylococcus aureus, Escherichia coli, Klebsiella pneumonia, and Pseudomonas aeruginosa. S. aureus and E. coli were found in all tested samples blood, pus, skin, urine. P. aeruginosa was found in pus and K. pneumonia in urine only. The identified strains were subjected to sensitivity testing against 7 different antibiotics i.e., ampicillin, piperacillin tazobactam, doxycycline, aztreonam, ciprofloxacin, levofloxacin and teicoplanin. Conclusion: All of the bacterial species were found resistant against the applied antibiotics except aztreonam. Keywords: Prevalence, antibiotics sensitivity, S. aureus, E. coli, K. pneumonia, P. aeruginosa

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Glycopeptide-resistant Staphylococcus aureus

Cited by 23 publications

References 17 publications

Prevalence of inducible clindamycin resistance in erythromycin resistant clinical isolates of Staphylococcus aureus and CONS at tertiary care hospital

Prevalence of inducible clindamycin resistance in erythromycin resistant clinical isolates of Staphylococcus aureus and CONS at tertiary care hospital

Development of a Novel Targeting System for Lethal Photosensitization of Antibiotic-Resistant Strains of Staphylococcus aureus

Prevalence of Antibiotic Resistant Bacteria among the Clinical Samples from Different Hospitals of Peshawar, Pakistan

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