Glycoproteins of Predicted Amphibian and Reptile Lyssaviruses Can Mediate Infection of Mammalian and Reptile Cells

Oberhuber, Martina; Schopf, Anika; Hennrich, Alexandru A; Santos-Mandujano, Rosalía; Huhn, Anna; Seitz, Stefan; Riedel, Christiane; Conzelmann, Karl‐Klaus

doi:10.3390/v13091726

Cited by 2 publications

(2 citation statements)

References 52 publications

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“…Lyssaviruses are neurotropic in mammals and abundant in infected skink brain tissue [ 25 ], suggesting they may also have detrimental neurological effects in reptilian hosts. Glycoproteins from reptile lyssaviruses demonstrate a broad animal host range, similar to rabies lyssavirus, indicating they may jump between reptile species and pose a significant viral threat [ 54 ].…”

Section: Discussionmentioning

confidence: 99%

Revealing the uncharacterised diversity of amphibian and reptile viruses

Harding

Russo²,

Yan³

et al. 2022

ISME Communications

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Amphibians and non-avian reptiles represent a significant proportion of terrestrial vertebrates, however knowledge of their viruses is not proportional to their abundance. Many amphibians and reptiles have strict habitual environments and localised populations and are vulnerable to viral outbreaks and potential elimination as a result. We sought to identify viruses that were hidden in amphibian and reptile metatranscriptomic data by screening 235 RNA-sequencing datasets from a 122 species covering 25 countries. We identified 26 novel viruses and eight previously characterised viruses from fifteen different viral families. Twenty-five viruses had RNA genomes with identity to Arteriviridae, Tobaniviridae, Hantaviridae, Rhabdoviridae, Astroviridae, Arenaviridae, Hepeviridae, Picornaviridae, Orthomyxoviridae, Reoviridae, Flaviviridae and Caliciviridae. In addition to RNA viruses, we also screened datasets for DNA viral transcripts, which are commonly excluded from transcriptomic analysis. We identified ten DNA viruses with identity to Papillomaviridae, Parvoviridae, Circoviridae and Adomaviridae. With the addition of these viruses, we expand the global amphibian and reptile virome and identify new potentially pathogenic viruses that could challenge populations. We speculate that amphibian viruses often have simpler genomes than those in amniotes, as in the case of the Secondpapillomavirinae and Orthomyxoviridae viruses identified in this study. In addition, we find evidence of inter-family recombination in RNA viruses, and we also identify new members of the recombinant Adomaviridae family. Overall, we provide insights into the uncharacterised diversity of amphibian and reptile viruses with the aim of improving population management, treatment and conservation into the future.

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Section: Discussionmentioning

confidence: 99%

Revealing the uncharacterised diversity of amphibian and reptile viruses

Harding

Russo²,

Yan³

et al. 2022

ISME Communications

View full text Add to dashboard Cite

show abstract

“…Additionally, phylogenetic analysis can be used to study gene gain and loss along evolutionary trajectories. Indeed, there are sufficient examples, where subsequent wet-lab research has proven the functionality of viruses discovered by in silico data mining, e.g., regarding their replication competence, genome replication mechanism, ultrastructural features, and virus–host interactions [ 18 , 46 , 47 , 48 ]. This demonstrates how classical (molecular) virology can benefit from the product generated by DDVD.…”

Section: Paradigms For Publication Of Data-driven Virus Discovery Res...mentioning

confidence: 99%

Opportunities and Challenges of Data-Driven Virus Discovery

Lauber

Seitz

2022

Biomolecules

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Virus discovery has been fueled by new technologies ever since the first viruses were discovered at the end of the 19th century. Starting with mechanical devices that provided evidence for virus presence in sick hosts, virus discovery gradually transitioned into a sequence-based scientific discipline, which, nowadays, can characterize virus identity and explore viral diversity at an unprecedented resolution and depth. Sequencing technologies are now being used routinely and at ever-increasing scales, producing an avalanche of novel viral sequences found in a multitude of organisms and environments. In this perspective article, we argue that virus discovery has started to undergo another transformation prompted by the emergence of new approaches that are sequence data-centered and primarily computational, setting them apart from previous technology-driven innovations. The data-driven virus discovery approach is largely uncoupled from the collection and processing of biological samples, and exploits the availability of massive amounts of publicly and freely accessible data from sequencing archives. We discuss open challenges to be solved in order to unlock the full potential of data-driven virus discovery, and we highlight the benefits it can bring to classical (mostly molecular) virology and molecular biology in general.

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Glycoproteins of Predicted Amphibian and Reptile Lyssaviruses Can Mediate Infection of Mammalian and Reptile Cells

Cited by 2 publications

References 52 publications

Revealing the uncharacterised diversity of amphibian and reptile viruses

Revealing the uncharacterised diversity of amphibian and reptile viruses

Opportunities and Challenges of Data-Driven Virus Discovery

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