1993
DOI: 10.1111/j.1399-6576.1993.tb03745.x
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Glycopyrrolate vs. atropine during anaesthesia for laryngoscopy and bronchoscopy

Abstract: As glycopyrrolate has been reported superior to atropine with respect to reduction of salivation, stability of cardiac rate and rhythm, and recovery, a comparison of these properties of the two drugs and placebo was made in 45 patients undergoing direct laryngoscopy and 45 patients undergoing bronchoscopy, in most cases followed by mediastinoscopy. When given i.m. 30 min before anesthesia (midazolam, alfentanil, thiopentone, and suxamethonium), the two test drugs were found to be equally potent regarding the a… Show more

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Cited by 19 publications
(10 citation statements)
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“…Randomized placebo-controlled trials are equivocal regarding the efficacy of atropine 61 and glycopyrrolate [62][63][64][65] to reduce gastric volume or acidity (Category C2 evidence).…”
Section: Preoperative Anticholinergicsmentioning
confidence: 99%
“…Randomized placebo-controlled trials are equivocal regarding the efficacy of atropine 61 and glycopyrrolate [62][63][64][65] to reduce gastric volume or acidity (Category C2 evidence).…”
Section: Preoperative Anticholinergicsmentioning
confidence: 99%
“…In a survey of Australian anaesthetists, very few used anticholinergic drugs routinely (21). In a study comparing three groups of patients undergoing laryngoscopy and bronchoscopy, those in the placebo group had a lower incidence of cardiac arrhythmia compared with those in the atropine group or the glycopyrrolate group (22).…”
Section: Anticholinergic Agentsmentioning
confidence: 99%
“…48 Premedication with small intramuscular doses of glycopyrrolate (0.005 mg·kg −1 ) 30 min prior to procedure is commonly seen in clinical practice. 100,101 Atropine use is discouraged as it has been associated with greater hemodynamic fluctuations and increased procedure time, 48 though available data on this subject are limited.…”
Section: Anesthetic Depth and Pharmacologic Considerationsmentioning
confidence: 99%