Glycosaminoglycan‐Based Biohybrid Hydrogels: A Sweet and Smart Choice for Multifunctional Biomaterials

Freudenberg, Uwe; Liang, Yingkai; Kiick, Kristi L.; Werner, Carsten

doi:10.1002/adma.201601908

Cited by 175 publications

(144 citation statements)

References 246 publications

(262 reference statements)

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“…Thiolated HA (3,3‐dithiobis‐[propanoic dihydrazide]) or thiol‐carboxymethyl HA can be crosslinked to form a hydrogel by the addition of PEG diacrylate. These composites have been used as injectable scar‐free 3D cell scaffolds for wound healing or as 3D cell culture scaffolds . Cyto‐adhesiveness of the material can be increased by co‐crosslinking with gelatin, modified with thiol groups, yielding a gel with tripeptide Arg‐Gly‐Asp (RGD) motifs for binding integrins on cell surfaces .…”

Section: Gelatin–polysaccharides Composites In Cell Culture and Tissumentioning

confidence: 99%

Gelatin‐polysaccharide composite scaffolds for 3D cell culture and tissue engineering: Towards natural therapeutics

Afewerki

Sheikhi

Kannan

et al. 2018

Bioengineering & Transla Med

309

210

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Gelatin is a promising material as scaffold with therapeutic and regenerative characteristics due to its chemical similarities to the extracellular matrix (ECM) in the native tissues, biocompatibility, biodegradability, low antigenicity, cost‐effectiveness, abundance, and accessible functional groups that allow facile chemical modifications with other biomaterials or biomolecules. Despite the advantages of gelatin, poor mechanical properties, sensitivity to enzymatic degradation, high viscosity, and reduced solubility in concentrated aqueous media have limited its applications and encouraged the development of gelatin‐based composite hydrogels. The drawbacks of gelatin may be surmounted by synergistically combining it with a wide range of polysaccharides. The addition of polysaccharides to gelatin is advantageous in mimicking the ECM, which largely contains proteoglycans or glycoproteins. Moreover, gelatin–polysaccharide biomaterials benefit from mechanical resilience, high stability, low thermal expansion, improved hydrophilicity, biocompatibility, antimicrobial and anti‐inflammatory properties, and wound healing potential. Here, we discuss how combining gelatin and polysaccharides provides a promising approach for developing superior therapeutic biomaterials. We review gelatin–polysaccharides scaffolds and their applications in cell culture and tissue engineering, providing an outlook for the future of this family of biomaterials as advanced natural therapeutics.

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Section: Gelatin–polysaccharides Composites In Cell Culture and Tissumentioning

confidence: 99%

Gelatin‐polysaccharide composite scaffolds for 3D cell culture and tissue engineering: Towards natural therapeutics

Afewerki

Sheikhi

Kannan

et al. 2018

Bioengineering & Transla Med

309

210

View full text Add to dashboard Cite

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“…A significant body of the literature surrounding the design and engineering of biointegrated hydrogels has developed around incorporating organic compounds, such as polysaccharides and proteins, into polymeric networks . These networks often display unique and interesting responsive functionalities, while also serving as bioactive materials that have the potential to generate therapeutic responses when implanted in a site of disease or damage in vivo.…”

Section: Responsive Biointegrated Hydrogelsmentioning

confidence: 99%

Biohybrid Design Gets Personal: New Materials for Patient‐Specific Therapy

Raman

Langer

2019

Advanced Materials

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Precision medicine requires materials and devices that can sense and adapt to dynamic physiological and pathological conditions. This motivates the design and manufacture of biohybrid materials that mimic the responsive behaviors demonstrated by natural biological systems. Two parallel approaches to biohybrid design are presented—biomimetics and biointegration. Biohybrid hydrogels that mimic the form and function of natural materials, or that integrate living cells or bioactive moieties, can respond to a range of environmental stimuli in parallel, including heat, light, pH, hydration, enzymes, and electric, mechanical, and magnetic forces. A range of examples that illustrate the tremendous potential of this nascent discipline are presented, and ongoing technical challenges related to manufacturing, storage, transport, and external noninvasive control of these materials that will need to be overcome in the coming years are outlined. The ethical, educational, and regulatory challenges that will govern translation of biohybrid design into medical applications are also discussed. Personalized medical therapies that target the precise needs of patients are a critically needed and expanding market. Biohybrid design offers the unique ability to manufacture materials and devices that match the dynamic and patient‐specific in vivo environment, promising to generate more effective and safe therapies that enable personalized care.

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“…[96] Various additives, including other polymers, can be added to tune solution properties critical for 3D printing. [103] Other bioinert hydrogels used in tissue engineering applications include poly(2-hydroxy ethyl methacrylate) (PHEMA), poly(acrylamide) (PA), and poly(Nisopropyl acrylamide) (PNIPAAm) and have been discussed elsewhere. [96,97] Hydrogels make up a large class of water-laden polymer networks that are typically biocompatible and have physiological stiffnesses similar to many tissues.…”

Section: Synthetic Polymersmentioning

confidence: 99%

Emerging Trends in Information‐Driven Engineering of Complex Biological Systems

et al. 2019

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Synthetic biological systems are used for a myriad of applications, including tissue engineered constructs for in vivo use and microengineered devices for in vitro testing. Recent advances in engineering complex biological systems have been fueled by opportunities arising from the combination of bioinspired materials with biological and computational tools. Driven by the availability of large datasets in the “omics” era of biology, the design of the next generation of tissue equivalents will have to integrate information from single‐cell behavior to whole organ architecture. Herein, recent trends in combining multiscale processes to enable the design of the next generation of biomaterials are discussed. Any successful microprocessing pipeline must be able to integrate hierarchical sets of information to capture key aspects of functional tissue equivalents. Micro‐ and biofabrication techniques that facilitate hierarchical control as well as emerging polymer candidates used in these technologies are also reviewed.

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Glycosaminoglycan‐Based Biohybrid Hydrogels: A Sweet and Smart Choice for Multifunctional Biomaterials

Cited by 175 publications

References 246 publications

Gelatin‐polysaccharide composite scaffolds for 3D cell culture and tissue engineering: Towards natural therapeutics

Gelatin‐polysaccharide composite scaffolds for 3D cell culture and tissue engineering: Towards natural therapeutics

Biohybrid Design Gets Personal: New Materials for Patient‐Specific Therapy

Emerging Trends in Information‐Driven Engineering of Complex Biological Systems

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