2019
DOI: 10.1016/j.jconrel.2019.10.018
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Glycosaminoglycan-based biomaterials for growth factor and cytokine delivery: Making the right choices

Abstract: Controlled, localized drug delivery is a long-standing goal of medical research, realization of which could reduce the harmful side-effects of drugs and allow more effective treatment of wounds, cancers, organ damage and other diseases. This is particularly the case for protein “drugs” and other therapeutic biological cargoes, which can be challenging to deliver effectively by conventional systemic administration. However, developing biocompatible materials that can sequester large quantities of protein and re… Show more

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Cited by 97 publications
(109 citation statements)
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References 197 publications
(258 reference statements)
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“…It acts primarily through a complex with antithrombin III thereby preventing formation of fibrin from fibrinogen and consequently prevents blood clotting. In addition, with a comparably high degree of sulfation and consequently strong negative charge, heparin belongs to a promising class of bio-active substances that can potentially enhance the biological effects of proteins due to binding and sustained and controlled release of cytokines including growth factors (reviewed recently by [6]).…”
Section: Introductionmentioning
confidence: 99%
“…It acts primarily through a complex with antithrombin III thereby preventing formation of fibrin from fibrinogen and consequently prevents blood clotting. In addition, with a comparably high degree of sulfation and consequently strong negative charge, heparin belongs to a promising class of bio-active substances that can potentially enhance the biological effects of proteins due to binding and sustained and controlled release of cytokines including growth factors (reviewed recently by [6]).…”
Section: Introductionmentioning
confidence: 99%
“…Cardiac grafts based on fetal rat ventricular muscle, [214] angiogenesis, [215a] colonoids, [223] cardiac fibrosis [339] Biopolymer-based hydrogels: Hyaluronic acid From rooster combs, shark skin, bovine eyeballs, or human umbilical cords [335] Animal-free produc- BMP, [343] NGF, SDF-1α) [342] Allows for hyaluronidases-mediated remodeling [267] or for degradation by reactive oxygen species [346] Engineered MMP degradation sites allow further degradation Undifferentiated hESC growth, [344] bone and cartilage engineering, [345] neural differentiation, [266] tumor modeling [229][230][231] [347] Microbial fermented HA synthesis provides pure, well-defined batches [348] Biopolymer-based hydrogels: Alginate…”
Section: Tissue-or Cell Culture-derived Decellularized Matricesmentioning
confidence: 99%
“…Allows for material processing for controlled cross-scale cell alignment and organization [135][136][137] Mediates cell adhesion via [342] Hyaluronidasesmediated remodeling [359] Human neural stem/progenitor cells [266] murine inner medullary collecting duct, [269b] human intestinal organoids [270] PEG requires careful consideration as, for instance, a fibroblastderived matrix was found to be unsuitable to sufficiently mimic the lung microenvironment in composition, structure and complexity. [101] Various types of matrices deposited by different cells (including fibroblasts, mesenchymal stroma/stem cells (MSCs), HEK293 cells, chondrocytes) have been investigated for their capability to sustain cell growth, maintain stemness, or guide differentiation.…”
mentioning
confidence: 99%
“…For example, the half-life of VEGF is approximately thirty-four minutes in plasma [ 51 ]. Therefore, biomaterials can serve as promising tools for the protection, delivery, and sustained release of growth factors and cytokines [ 52 ]. Table 1 summarizes the use of biomaterials loaded with growth factors and cytokines for cardiac tissue regeneration.…”
Section: Biomaterials Loaded With Growth Factors and Cytokines Formentioning
confidence: 99%