Glycosaminoglycans from marine sources as therapeutic agents

Valcárcel, Jesús; Novoa-Carballal, Ramón; Pérez‐Martín, Ricardo I.; Reis, Rui L.; Vázquez, José Antonio

doi:10.1016/j.biotechadv.2017.07.008

Cited by 143 publications

(102 citation statements)

References 162 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, mammalian CS is observed to be predominantly be 4 sulfation position, which is the main source of CS, derived from the cartilage of terrestrial animal sources such as bovine, porcine, and avian ones. Other utilized CS sources are marine organisms, mainly sharks; these show differences with terrestrial CS in terms of molecular weight and sulfation . The existence of CS sources with low C4S/C6S ratios (prevalence of six sulfation position) in common and sustainable fish by‐products (from the fish processing industry) such as small‐spotted catshark ( Scyliorhinus canicula , whole body), blue shark ( Prionace glauca , head), and ray ( Raja clavata , skeleton) was recently published …”

Section: Introductionmentioning

confidence: 99%

Quantitative evaluation of sulfation position prevalence in chondroitin sulphate by Raman spectroscopy

López‐Álvarez

López-Senra

Valcárcel

et al. 2019

J Raman Spectroscopy

Self Cite

View full text Add to dashboard Cite

Chondroitin sulphate (CS) as a major component of the extracellular matrix of numerous connective tissues is responsible for biomechanical properties such as resistance and elasticity. It occurs in different isomeric forms with different sites and degrees of sulfation. The characterization of crude CS and quantitative isomeric identification by high‐performance liquid chromatography (HPLC) requires specific enzymes, expensive reagents, and a complicated analytical process. Poor reproducibility and imprecise quantification were found with other methodologies. Raman spectroscopy allows rapid and reproducible identification of CS isomers offering specificity and avoids the need for sample pretreatment or external markers. In the present work, a quantitative identification of major contribution of isomeric chondroitin 4 and 6‐sulphate in crude CS by Raman spectroscopy has been performed. Two quantitative indices have been proposed based on areas of specific bands of interest related to main skeletal modes, an aromatic ring with axial orientation in the case of the major contribution of 4‐sulphate and C‐O‐(S) vibration, which is heavily detected in the case of the major contribution of 6‐sulphate. Both mammalian and fish sources of CS were used to validate the ability of mentioned indices to discriminate between prevalence of 4‐sulphate, 6‐sulphate, or none of them. Correspondence of given results with HPLC was demonstrated.

show abstract

Section: Introductionmentioning

confidence: 99%

Quantitative evaluation of sulfation position prevalence in chondroitin sulphate by Raman spectroscopy

López‐Álvarez

López-Senra

Valcárcel

et al. 2019

J Raman Spectroscopy

Self Cite

View full text Add to dashboard Cite

show abstract

“…They contain valuable glycosaminoglycans which are mainly chondroitin-4-sulfate and chondroitin-6-sulfate, present in the form of proteoglycans (Garnjanagoonchorn et al, 2007). Glycosaminoglycans originating from marine sources are different from those of terrestrial organisms, mainly in terms of their molecular weight and sulfation (Valcarcel et al,2017). For example, marine glycosaminoglycans have distinct sulfation with different interrelated aspects such as the relative abundance of sulfated units which varies between marine and terrestrial glycosaminoglycans.…”

Section: Proteoglycanmentioning

confidence: 99%

“…For example, marine glycosaminoglycans have distinct sulfation with different interrelated aspects such as the relative abundance of sulfated units which varies between marine and terrestrial glycosaminoglycans. The rare disaccharide units, such as chondroitin sulfate-keratan, are only found in marine sources (Higashi et al, 2015;Valcarcel et al, 2017). Chondroitin sulfate is a typical mucopolysaccharide (Guérard, 2007).…”

Section: Proteoglycanmentioning

confidence: 99%

“…Moreover, as inflammatory agents, marine originated chondroitin sulfate plays an important role. Shrimp heparin, fucosylated chondroitin sulfate from sea cucumber, and chondroitin sulfate from shark cartilage are some of the marine originated anti-inflammatory agents that show in vitro and in vivo activities (Valcarcel et al, 2017). Apart from these therapeutic activities, chondroitin sulfate also appears as the most promising compound which promotes neurite outgrowth and can be utilized for nerve regeneration (Sugahara and Mikami, 2007;Serrano et al,2014 ) Chondroitin sulfate extracted from shark, ascidians, sea urchin, squid and octopus showed neurite outgrowth promoting characteristics (Higashi et al,2015;Li et al, 2007);) as well as potential for nerve regeneration (Valcarcel et al, 2017).…”

Section: Proteoglycanmentioning

confidence: 99%

See 1 more Smart Citation

Utilization of marine by-products for the recovery of value-added products

Shahidi¹,

Varatharajan²,

Han³

et al. 2019

Journal of Food Bioactives

View full text Add to dashboard Cite

The world fisheries resources have exceeded 160 million tons in recent years. However, every year a considerable amount of total catch is discarded as by-catch or as processing leftovers, and that includes trimmings, fins, frames, heads, skin, viscera and among others. In addition, a large quantity of processing by-products is accumulated as shells of crustaceans and shellfish from marine bioprocessing plants. Recognition of the limited marine resources and the increasing environmental pollution has emphasized the need for better utilization of the by-products. Marine by-products contain valuable protein and lipid fractions, minerals, enzymes as well as many other components. The major fraction of by-products are used for feed production-in making fish meal/oil, but this has low profitability. However, there are many ways in which the fish and shellfish waste could be better utilized, including the production of novel food ingredients, nutraceuticals, pharmaceuticals, biomedical materials, fine chemicals, and other value-added products. In recent times, much research is conducted in order to explore the possible uses of different by-products. This contribution primarily covers the characteristics and utilization of the main ingredients such as protein, lipid, chitin and its derivatives, enzymes, carotenoids, and minerals originating from marine by-products.

show abstract

“…Interestingly, these interactions are specifically inhibited by CS or DS chains containing the E unit and iE unit (IdoUA-GalNAc(4S,6S)), respectively (1). Furthermore, E unit-rich CS polysaccharides, such as CS-E from squid cartilage, show remarkable biological activities, such as promotion of neurite outgrowth (24)(25)(26), inhibition of viral infection (13,27,28), and osteoanabolism induced by estrogen (29). Studies of the structure-function relationship of E unit-containing polysaccharides have shown that E unit-rich domains in these CS/DS chains play key roles in various biological functions, and the minimal essential structures for various bioactivities of CS-E have been identified (11,(30)(31)(32).…”

Section: Introductionmentioning

confidence: 99%