Glycosaminoglycans (GASs) in human cerebral tumors

Bertolotto, Antonio; Giordana, Maria Teresa; Magrassi, M. L.; Mauro, Alessandro; Schiffer, Davide

doi:10.1007/bf00691651

Cited by 18 publications

(2 citation statements)

References 22 publications

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“…This relationship may be descriptive for meningiomas, which have variable fibrous matrix fractions. As glial tumors have a high content of extremely hydrophilic GAGs, the matrix readily binds water in a gel-like substance 49 and remains more solid. Conversely, the ECM of meningiomas is rich in collagen and while still hydrophilic, is less so than GAGs.…”

Section: Discussionmentioning

confidence: 99%

Magnetic Resonance Elastography in Intracranial Neoplasms: A Scoping Review

Aunan-Diop

Halle

Pedersen

et al. 2022

Topics in Magnetic Resonance Imaging

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Background: Magnetic resonance elastography (MRE) allows noninvasive assessment of intracranial tumor mechanics and may thus be predictive of intraoperative conditions. Variations in the use of technical terms complicate reading of current literature, and there is need of a review using consolidated nomenclature. Objectives:We present an overview of current literature on MRE relating to human intracranial neoplasms using standardized nomenclature suggested by the MRE guidelines committee. We then discuss the implications of the findings, and suggest approaches for future research. Method:We performed a systematic literature search in PubMed, Embase, and Web of Science; the articles were screened for relevance and then subjected to full text review. Technical terms were consolidated. Results:We identified 12 studies on MRE in patients with intracranial tumors, including meningiomas, glial tumors including glioblastomas, vestibular schwannomas, hemangiopericytoma, central nervous system lymphoma, pituitary macroadenomas, and brain metastases. The studies had varying objectives that included prediction of intraoperative consistency, histological separation, prediction of adhesiveness, and exploration of the mechanobiology of tumor invasiveness and malignancy. The technical terms were translated using standardized nomenclature. The literature was highly heterogeneous in terms of image acquisition techniques, post-processing, and study design and was generally limited by small and variable cohorts.Conclusions: MRE shows potential in predicting tumor consistency, adhesion, and mechanical homogeneity. Furthermore, MRE provides insight into malignant tumor behavior and its relation to tissue mechanics. MRE is still at a preclinical stage, but technical advances, improved understanding of soft tissue rheological impact, and larger samples are likely to enable future clinical introduction.

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Section: Discussionmentioning

confidence: 99%

Magnetic Resonance Elastography in Intracranial Neoplasms: A Scoping Review

Aunan-Diop

Halle

Pedersen

et al. 2022

Topics in Magnetic Resonance Imaging

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“…Regarding T1 relaxivity, gadobutrol (gadolinium-DO3A-butrol; Gadovist 1.0; Bayer Schering Pharma) is a 1.0 mmol/ mL gadolinium chelate agent with approximately 14%-27% higher T1 relaxivity than half-molar GBCAs on 3T MR imaging. 17,18 The concentration of GBCA in the ROI is determined by the interactions between the contrast agent molecules and tissues, and the nonionic property of gadobutrol is thought to affect tissue interactions and accumulation rates in a manner different from those of ionic GBCAs. 13,14 Glioma is rich in negatively-charged glycosaminoglycans, [19][20][21] and differences in ionic properties between gadobutrol and gadoterate meglumine (Dotarem; Guerbet), may affect modelfree or quantitative pharmacokinetic DCE parameters; however, there is a lack of studies comparing the 2 types of GBCA in DCE imaging, with the 2 types having been used interchangeably to date.…”

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confidence: 99%

Comparison of Dynamic Contrast-Enhancement Parameters between Gadobutrol and Gadoterate Meglumine in Posttreatment Glioma: A Prospective Intraindividual Study

Park

Kim

et al. 2020

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE: Differences in molecular properties between one-molar and half-molar gadolinium-based contrast agents are thought to affect parameters obtained from dynamic contrast-enhanced imaging. The aim of our study was to investigate differences in dynamic contrast-enhanced parameters between one-molar nonionic gadobutrol and half-molar ionic gadoterate meglumine in patients with posttreatment glioma. MATERIALS AND METHODS:This prospective study enrolled 32 patients who underwent 2 20-minute dynamic contrast-enhanced examinations, one with gadobutrol and one with gadoterate meglumine. The model-free parameter of area under the signal intensity curve from 30 to 1100 seconds and the Tofts model-based pharmacokinetic parameters were calculated and compared intraindividually using paired t tests. Patients were further divided into progression (n = 12) and stable (n = 20) groups, which were compared using Student t tests.RESULTS: Gadobutrol and gadoterate meglumine did not show any significant differences in the area under the signal intensity curve or pharmacokinetic parameters of K trans , V e , V p , or K ep (all P . .05). Gadobutrol showed a significantly higher mean wash-in rate (0.83 6 0.64 versus 0.29 6 0.63, P ¼ .013) and a significantly lower mean washout rate (0.001 6 0.0001 versus 0.002 6 0.002, P ¼ .02) than gadoterate meglumine. Trends toward higher area under the curve, K trans , V e , V p , wash-in, and washout rates and lower K ep were observed in the progression group in comparison with the treatment-related-change group, regardless of the contrast agent used.CONCLUSIONS: Model-free and pharmacokinetic parameters did not show any significant differences between the 2 gadoliniumbased contrast agents, except for a higher wash-in rate with gadobutrol and a higher washout rate with gadoterate meglumine, supporting the interchangeable use of gadolinium-based contrast agents for dynamic contrast-enhanced imaging in patients with posttreatment glioma. ABBREVIATIONS: DCE ¼ dynamic contrast-enhanced; CE ¼ contrast-enhanced; GBCA ¼ gadolinium-based contrast agent; IAUC ¼ initial area under the time-to-signal intensity curve; K ep ¼ rate transfer constant; K trans ¼ volume transfer constant; V e ¼ extravascular-extracellular space per unit volume of tissue; V p ¼ blood plasma volume per unit volume of tissue; WHO ¼ World Health Organization

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The Networking Brain: How Extracellular Matrix, Cellular Networks, and Vasculature Shape the In Vivo Mechanical Properties of the Brain

Bergs,

Morr,

Silva

et al. 2024

Advanced Science

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Mechanically, the brain is characterized by both solid and fluid properties. The resulting unique material behavior fosters proliferation, differentiation, and repair of cellular and vascular networks, and optimally protects them from damaging shear forces. Magnetic resonance elastography (MRE) is a noninvasive imaging technique that maps the mechanical properties of the brain in vivo. MRE studies have shown that abnormal processes such as neuronal degeneration, demyelination, inflammation, and vascular leakage lead to tissue softening. In contrast, neuronal proliferation, cellular network formation, and higher vascular pressure result in brain stiffening. In addition, brain viscosity has been reported to change with normal blood perfusion variability and brain maturation as well as disease conditions such as tumor invasion. In this article, the contributions of the neuronal, glial, extracellular, and vascular networks are discussed to the coarse‐grained parameters determined by MRE. This reductionist multi‐network model of brain mechanics helps to explain many MRE observations in terms of microanatomical changes and suggests that cerebral viscoelasticity is a suitable imaging marker for brain disease.

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Glycosaminoglycans (GASs) in human cerebral tumors

Cited by 18 publications

References 22 publications

Magnetic Resonance Elastography in Intracranial Neoplasms: A Scoping Review

Magnetic Resonance Elastography in Intracranial Neoplasms: A Scoping Review

Comparison of Dynamic Contrast-Enhancement Parameters between Gadobutrol and Gadoterate Meglumine in Posttreatment Glioma: A Prospective Intraindividual Study

The Networking Brain: How Extracellular Matrix, Cellular Networks, and Vasculature Shape the In Vivo Mechanical Properties of the Brain

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