Glycosaminoglycans in Gingival Crevicular Fluid of Patients With Periodontal Class II Furcation Involvement Before and After Guided Tissue Regeneration. A Pilot Study

Yan, Fuhua; Marshall, Rod; Wynne, Susan; Xiao, Yin; Bartold, P. Mark

doi:10.1902/jop.2000.71.1.1

Cited by 9 publications

(9 citation statements)

References 26 publications

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“…Thirty‐four articles were excluded after full‐text review (Table 3). 10‐12,16,30‐59 A final selection of 150 articles was made, of which six were systematic reviews, 2,60‐64 109 were clinical trials, 53,65‐172 27 were case series, 173‐199 and eight were case reports 200‐207 . No cohort studies were identified.…”

Section: Resultsmentioning

confidence: 99%

Periodontal Regeneration – Furcation Defects: A Systematic Review From the AAP Regeneration Workshop

Ávila‐Ortiz

Buitrago

Reddy

2015

Journal of Periodontology

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Background: The aim of this review is to present the available evidence regarding the effectiveness of different regenerative approaches for the treatment of furcation defects in specific clinical scenarios compared with conventional surgical therapy to provide clinical guidelines for the therapeutic management of furcation defects and to identify priorities for future research that may advance the understanding of periodontal regenerative medicine.Methods: A comprehensive search based on predetermined eligibility criteria was conducted to identify human original studies and systematic reviews on the topic of periodontal regeneration of furcation defects. Two reviewers independently screened the title and abstract of the entries yielded from the initial search. Subsequently, both reviewers read the full-text version of potentially eligible studies, made a final article selection, and extracted the data of the selected studies considering specific clinical scenarios. The clinical scenarios contemplated in this review included the following: 1) facial and interproximal Class I defects in maxillary molars; 2) facial and lingual Class I defects in mandibular molars; 3) facial and interproximal Class II furcation defects in maxillary molars; 4) facial and lingual Class II furcation defects in mandibular molars; 5) Class III furcation defects in maxillary molars; 6) Class III furcation defects in mandibular molars; and 7) Class I, II, or III furcation defects in maxillary premolars. Endpoints of interest included different clinical, radiographic, microbiologic, histologic, and patient-reported outcomes.Results: The initial search yielded a total of 1,500 entries. The final selection consisted of 150 articles, of which six were systematic reviews, 109 were clinical trials, 27 were case series, and eight were case reports. A summary of the main findings of previously published systematic reviews and the available evidence relative to the indication of regenerative approaches for the treatment of furcation defects compared with conventional surgical therapy are presented. Given the marked methodologic heterogeneity and the wide variety of materials and techniques applied in the selected clinical trials, the conduction of a meta-analysis was not viable.Conclusions: On the basis of the reviewed evidence, the following conclusions can be drawn. 1) Periodontal regeneration has been demonstrated histologically and clinically for the treatment of maxillary facial or interproximal and mandibular facial or lingual Class II furcation defects. 2) Although periodontal regeneration has been demonstrated histologically for the treatment of mandibular Class III defects, the evidence is limited to one case report. 3) Evidence supporting regenerative therapy in maxillary Class III furcation defects in maxillary molars is limited to clinical case reports. 4) In Class I furcation defects, regenerative therapy may be beneficial in certain clinical scenarios, although most Class I furcation defects may be successfully treated with non-regen...

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Section: Resultsmentioning

confidence: 99%

Periodontal Regeneration – Furcation Defects: A Systematic Review From the AAP Regeneration Workshop

Ávila‐Ortiz

Buitrago

Reddy

2015

Journal of Periodontology

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“…This most probably reflects the early inflammatory stage of periodontal wound healing, which is accompanied by enhanced permeability of gingival blood vessels and increased fluid passage through the vasculature into the extravascular space (Egelberg 1966). Elevated GCF volumes have previously been reported 1 week following GTR surgery of periodontal Class II furcation defects (Yan et al 2000), and have even been observed within 2 days following a single episode of non‐surgical treatment of periodontal pockets (Talonpoika & Hämäläinen 1992, 1993, Talonpoika et al 1993). Notably, the present study also found that this apparent inflammatory effect persisted for a prolonged period at the GTR test sites, since there was a statistically significant increase in average GCF volumes in the 6‐week period during which the membrane was in position and also 1 week following its removal, prior to decreasing to pre‐surgical levels by 12 weeks.…”

Section: Discussionmentioning

confidence: 96%

“…This is consistent with previous observations that, during healing after periodontal treatment, newly synthesised connective tissue components such as collagen types I and III and fibronectin are present at elevated levels in the GCF of treated sites, as noted above (Talonpoika & Hämäläinen 1992, 1993, Talonpoika et al 1993). Periodontal therapy has also been shown to modulate GCF levels of glycosaminoglycans (Yan et al 2000), matrix metalloproteinases (Said et al 1999) and their tissue inhibitors (Haerian et al 1996), while cells of regenerated periodontal tissue express relatively high levels of matrix components collagen type I, fibronectin and tenascin (Kuru et al 2001) and cell surface receptors specific for the growth factor TGF‐ β 1 (Parkar et al 2001).…”

Section: Discussionmentioning

confidence: 99%

Changes in transforming growth factor‐β1 in gingival crevicular fluid following periodontal surgery

Kuru

Griffiths

Petrie

et al. 2004

J Clinic Periodontology

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“…While less attention has been placed on the decorin and biglycan components of cartilage, SLRP metabolite levels in synovial fluid have also been shown to correlate with disease activity 24,25 , 27,28 . Similar studies in relation to periodontal disease have identified a GAG‐containing proteoglycan metabolite in GCF and saliva as an ideal biomarker of disease activity, 29,30 with levels returning to normal following various clinical interventions 29,30 , 107,108 . Biochemical characterization of this metabolite has identified it as being a chondroitin sulphate proteoglycan‐derived, with immunoreactivity to decorin from the alveolar bone of the periodontium 108 .…”

Section: Proteoglycansmentioning

confidence: 98%

Extracellular matrix metabolites as potential biomarkers of disease activity in wound fluid: lessons learned from other inflammatory diseases?

et al. 2004

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The new era of pharmacogenetics has identified a potential for individuals to receive customized treatments for a variety of disease states. For such individualized treatments to fulfil their potential, it will be essential for clinicians to be able to monitor disease activity, ideally in a rapid, noninvasive fashion. The accessibility of the skin offers much potential to develop noninvasive tests of metabolic and disease activity for clinical use. Impaired human wound healing in the skin is a chronic inflammatory disorder in which the development of such tests has considerable potential, aiding clinical decision making and monitoring responses to treatment. This review article discusses how studies in other human diseases have highlighted potential biochemical markers (biomarkers) of disease activity in secreted biofluids, as aids to determining disease and metabolic activity within tissues. Using, as examples, lessons learned in the study of disease activity and prognosis of other chronic inflammatory conditions, such as osteoarthritis and periodontal disease, this review highlights the potential of dermal extracellular matrix (ECM) components (collagens, proteoglycans, hyaluronan and glycoproteins) for such uses. The limitations of currently utilized techniques and the concept that analysis of ECM components in wound fluid may represent useful biomarkers of disease activity are also discussed.

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Glycosaminoglycans in Gingival Crevicular Fluid of Patients With Periodontal Class II Furcation Involvement Before and After Guided Tissue Regeneration. A Pilot Study

Cited by 9 publications

References 26 publications

Periodontal Regeneration – Furcation Defects: A Systematic Review From the AAP Regeneration Workshop

Periodontal Regeneration – Furcation Defects: A Systematic Review From the AAP Regeneration Workshop

Changes in transforming growth factor‐β1 in gingival crevicular fluid following periodontal surgery

Extracellular matrix metabolites as potential biomarkers of disease activity in wound fluid: lessons learned from other inflammatory diseases?

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