2022

DOI: 10.1016/j.phymed.2022.154385

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Glycosides from Buyang Huanwu Decoction inhibit atherosclerotic inflammation via JAK/STAT signaling pathway

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Cited by 45 publications

(12 citation statements)

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“…After endothelial cell injury, it will release inflammatory mediators and Cell adhesion molecule, promote the adhesion and infiltration of Monocyte and T lymphocytes, and trigger inflammatory reaction. [11][12][13][14] Low density lipoprotein cholesterol (LDL-C) is ingested, oxidized, and modified in the vascular wall of endothelial injury. Oxidized LDL can induce Monocyte to transform into macrophages, and engulf oxidized LDL to form Foam cell.…”

Section: Discussionmentioning

confidence: 99%

High expression of CASP1 induces atherosclerosis

Li,

Du,

Meng

et al. 2024

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Atherosclerosis is a chronic, progressive vascular disease. The relationship between CASP1 gene expression and atherosclerosis remains unclear. The atherosclerosis dataset GSE132651 and GSE202625 profiles were downloaded from gene expression omnibus. Differentially expressed genes (DEGs) were screened. The construction and analysis of protein–protein interaction network, functional enrichment analysis, gene set enrichment analysis, and Comparative Toxicogenomics Database analysis were performed. Gene expression heatmap was drawn. TargetScan was used to screen miRNAs that regulate central DEG. 47 DEGs were identified. According to gene ontology analysis, they were mainly enriched in the regulation of stimulus response, response to organic matter, extracellular region, extracellular region, and the same protein binding. Kyoto Encyclopedia of Gene and Genome analysis results showed that the target cells were mainly enriched in the PI3K-Akt signaling pathway, Ras signaling pathway, and PPAR signaling pathway. In the enrichment project of Metascape, vascular development, regulation of body fluid levels, and positive regulation of cell motility can be seen in the gene ontology enrichment project. Eleven core genes (CASP1, NLRP3, MRC1, IRS1, PPARG, APOE, IL13, FGF2, CCR2, ICAM1, HIF1A) were obtained. IRS1, PPARG, APOE, FGF2, CCR2, and HIF1A genes are identified as core genes. Gene expression heatmap showed that CASP1 was highly expressed in atherosclerosis samples and low expressed in normal samples. NLRP3, MRC1, IRS1, PPARG, APOE, IL13, FGF2, CCR2, ICAM1, HIF1A were low expressed in atherosclerosis samples. CTD analysis showed that 5 genes (CASP1, NLRP3, CCR2, ICAM1, HIF1A) were found to be associated with pneumonia, inflammation, cardiac enlargement, and tumor invasiveness. CASP1 gene is highly expressed in atherosclerosis. The higher the CASP1 gene, the worse the prognosis.

“…After endothelial cell injury, it will release inflammatory mediators and Cell adhesion molecule, promote the adhesion and infiltration of Monocyte and T lymphocytes, and trigger inflammatory reaction. [11][12][13][14] Low density lipoprotein cholesterol (LDL-C) is ingested, oxidized, and modified in the vascular wall of endothelial injury. Oxidized LDL can induce Monocyte to transform into macrophages, and engulf oxidized LDL to form Foam cell.…”

Section: Discussionmentioning

confidence: 99%

High expression of CASP1 induces atherosclerosis

Li,

Du,

Meng

et al. 2024

View full text Add to dashboard Cite

Atherosclerosis is a chronic, progressive vascular disease. The relationship between CASP1 gene expression and atherosclerosis remains unclear. The atherosclerosis dataset GSE132651 and GSE202625 profiles were downloaded from gene expression omnibus. Differentially expressed genes (DEGs) were screened. The construction and analysis of protein–protein interaction network, functional enrichment analysis, gene set enrichment analysis, and Comparative Toxicogenomics Database analysis were performed. Gene expression heatmap was drawn. TargetScan was used to screen miRNAs that regulate central DEG. 47 DEGs were identified. According to gene ontology analysis, they were mainly enriched in the regulation of stimulus response, response to organic matter, extracellular region, extracellular region, and the same protein binding. Kyoto Encyclopedia of Gene and Genome analysis results showed that the target cells were mainly enriched in the PI3K-Akt signaling pathway, Ras signaling pathway, and PPAR signaling pathway. In the enrichment project of Metascape, vascular development, regulation of body fluid levels, and positive regulation of cell motility can be seen in the gene ontology enrichment project. Eleven core genes (CASP1, NLRP3, MRC1, IRS1, PPARG, APOE, IL13, FGF2, CCR2, ICAM1, HIF1A) were obtained. IRS1, PPARG, APOE, FGF2, CCR2, and HIF1A genes are identified as core genes. Gene expression heatmap showed that CASP1 was highly expressed in atherosclerosis samples and low expressed in normal samples. NLRP3, MRC1, IRS1, PPARG, APOE, IL13, FGF2, CCR2, ICAM1, HIF1A were low expressed in atherosclerosis samples. CTD analysis showed that 5 genes (CASP1, NLRP3, CCR2, ICAM1, HIF1A) were found to be associated with pneumonia, inflammation, cardiac enlargement, and tumor invasiveness. CASP1 gene is highly expressed in atherosclerosis. The higher the CASP1 gene, the worse the prognosis.

“…[20][21][22] For example, glycosides from Buyang Huanwu Decoction modulates the JAK/STAT pathway to reduce atherosclerotic inflammation. 23 Furthermore, FPS-ZM1 retards the JAK/STAT signaling pathway to suppress LPS-triggered microglial inflammation. 24 Additionally, baicalin blocks JAK/STAT pathway to modulate macrophage polarization and mitigate myocardial ischemia/reperfusion injury.…”

Section: Discussionmentioning

confidence: 99%

“…The JAK/STAT signaling pathway has been affirmed to be a key pathway in some diseases to ameliorate inflammation 20–22 . For example, glycosides from Buyang Huanwu Decoction modulates the JAK/STAT pathway to reduce atherosclerotic inflammation 23 . Furthermore, FPS‐ZM1 retards the JAK/STAT signaling pathway to suppress LPS‐triggered microglial inflammation 24 .…”

Section: Discussionmentioning

confidence: 99%

Forsythiaside A exhibits anti‐migration and anti‐inflammation effects in rheumatoid arthritis in vitro model

Su,

Zhou,

Huang

et al. 2023

Int J of Rheum Dis

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BackgroundRheumatoid arthritis (RA) is a kind of systemic autoimmune disease, and the joint inflammation and cartilage destruction are the major features. Some traditional Chinese medicine have been discovered to exhibit regulatory roles in the treatment of RA. Forsythiaside A (FA) as an active ingredient isolated from forsythia suspensa has been discovered to participate into the regulation of some diseases through improving inflammation. However, the regulatory effects of FA on the progression of RA keep indistinct.MethodsIL‐1β treatment (10 ng/mL) in MH7A cells was built to mimic RA in vitro (cell) model. The cell viability was examined through CCK‐8 assay. The cell proliferation was detected through Edu assay. The levels of TNF‐α, IL‐6, and IL‐8 were evaluated through ELISA. The protein expressions were measured through western blot. The cell apoptosis was assessed through flow cytometry. The cell migration and invasion abilities were tested through Transwell assay.ResultsIn this study, it was revealed that the cell proliferation was strengthened after IL‐1β treatment (p < .001), but this effect was reversed after FA treatment in a dose‐increasing manner (p < .05). Furthermore, FA suppressed inflammation in IL‐1β‐triggered MH7A cells through attenuating the levels of TNF‐α, IL‐6, and IL‐8 (p < .05). The cell apoptosis was lessened after IL‐1β treatment (p < .001), but this effect was rescued after FA treatment (p < .05). Besides, the cell migration and invasion abilities were both increased after IL‐1β treatment (p < .001), but these changes were offset after FA treatment (p < .05). Eventually, FA retarded the JAK/STAT pathway through reducing p‐JAK/JAK and p‐STAT/STAT levels (p < .01).ConclusionOur study manifested that FA exhibited anti‐migration and anti‐inflammation effects in RA in vitro model (IL‐1β‐triggered MH7A cells) through regulating the JAK/STAT pathway. This work hinted that FA can be an effective drug for RA treatment.

“…Astra-galoside was then identified as one of the absorbed bioactive compounds present in DBD and can be detected in the serum of (GK) rats following administration [ 71 ]. Astra-galoside IV was also shown to be the main active components of Buyang Huanwu Decoction (BYHWD) and could inhibit AS by alleviating atherosclerotic inflammation via the inhibition on the activation of Janus tyrosine kinase (JAK)/signal transducer and activator of tranion (STAT) signaling pathway [ 72 ]. Astra-galoside IV combined with Tanshinone IIA has been found to significantly decrease lipid areas, increase collagen content and thicken the fibrous cap in the right common carotid arteries in ApoE −/− atherosclerotic mice, and visibly reduce the ox-LDL-induced cytoplasmic lipid droplet accumulation in RAW264.7 macrophages through regulating the PI3K/AKT and TLR4/NF-κB signaling.…”

Section: Astra-galosidesmentioning

confidence: 99%

Advances in the Bioactivities of Phytochemical Saponins in the Prevention and Treatment of Atherosclerosis

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Atherosclerosis (AS) is a chronic inflammatory disease characterized by hardening and narrowing of arteries. AS leads to a number of arteriosclerotic vascular diseases including cardiovascular diseases, cerebrovascular disease and peripheral artery disease, which pose a big threat to human health. Phytochemicals are a variety of intermediate or terminal low molecular weight secondary metabolites produced during plant energy metabolism. Phytochemicals from plant foods (vegetables, fruits, whole grains) and traditional herb plants have been shown to exhibit multiple bioactivities which are beneficial for prevention and treatment against AS. Many types of phytochemicals including polyphenols, saponins, carotenoids, terpenoids, organic sulfur compounds, phytoestrogens, phytic acids and plant sterols have already been identified, among which saponins are a family of glycosidic compounds consisting of a hydrophobic aglycone (sapogenin) linked to hydrophilic sugar moieties. In recent years, studies have shown that saponins exhibit a number of biological activities such as anti-inflammation, anti-oxidation, cholesterol-lowering, immunomodulation, anti-platelet aggregation, etc., which are helpful in the prevention and treatment of AS. This review aims to summarize the recent advances in the anti-atherosclerotic bioactivities of saponins such as ginsenoside, soyasaponin, astra-galoside, glycyrrhizin, gypenoside, dioscin, saikosaponin, etc.

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