Glycosides from ginseng roots

Elyakov, G. B.; Strigina, L. I.; Uvarova, N. I.; Vaskovsky, V.E.; Dzizenko, A. K.; Kochetkov, N. K.

doi:10.1016/s0040-4039(01)89378-3

Cited by 30 publications

(9 citation statements)

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“…Ginsenosides were isolated in the 1960s for the first time [23] , and many types of ginsenosides have been identified. Ginsenosides are triperpene saponins that originated from 2, 3-oxidosqualene.…”

Section: The Chemical Constituents Of P Ginsengmentioning

confidence: 99%

Systems-level mechanisms of action of Panax ginseng: a network pharmacological approach

Park

Kim

et al. 2018

Journal of Ginseng Research

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Panax ginseng has been used since ancient times based on the traditional Asian medicine theory and clinical experiences, and currently, is one of the most popular herbs in the world. To date, most of the studies concerning P. ginseng have focused on specific mechanisms of action of individual constituents. However, in spite of many studies on the molecular mechanisms of P. ginseng, it still remains unclear how multiple active ingredients of P. ginseng interact with multiple targets simultaneously, giving the multidimensional effects on various conditions and diseases. In order to decipher the systems-level mechanism of multiple ingredients of P. ginseng, a novel approach is needed beyond conventional reductive analysis. We aim to review the systems-level mechanism of P. ginseng by adopting novel analytical framework–network pharmacology. Here, we constructed a compound-target network of P. ginseng using experimentally validated and machine learning-based prediction results. The targets of the network were analyzed in terms of related biological process, pathways, and diseases. The majority of targets were found to be related with primary metabolic process, signal transduction, nitrogen compound metabolic process, blood circulation, immune system process, cell-cell signaling, biosynthetic process, and neurological system process. In pathway enrichment analysis of targets, mainly the terms related with neural activity showed significant enrichment and formed a cluster. Finally, relative degrees analysis for the target-disease association of P. ginseng revealed several categories of related diseases, including respiratory, psychiatric, and cardiovascular diseases.

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Section: The Chemical Constituents Of P Ginsengmentioning

confidence: 99%

Systems-level mechanisms of action of Panax ginseng: a network pharmacological approach

Park

Kim

et al. 2018

Journal of Ginseng Research

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“…Since the first isolation of six ginsenosides derived from Ginseng in the 1960s [ 94 ], many ginsenosides have been isolated and identified. Among various ginsenosides, Rb 1 , Rg 1 , Rg 3 , Re, and Rd are the most frequently studied variants, and the structures of some typical constituents are given in Figure 3(b) .…”

Section: Pharmacological Intervention With Chinese Herbsmentioning

confidence: 99%

Therapeutic Effects of Traditional Chinese Medicine on Spinal Cord Injury: A Promising Supplementary Treatment in Future

Zhang

Yang

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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Objective. Spinal cord injury (SCI) is a devastating neurological disorder caused by trauma. Pathophysiological events occurring after SCI include acute, subacute, and chronic phases, while complex mechanisms are comprised. As an abundant source of natural drugs, Traditional Chinese Medicine (TCM) attracts much attention in SCI treatment recently. Hence, this review provides an overview of pathophysiology of SCI and TCM application in its therapy. Methods. Information was collected from articles published in peer-reviewed journals via electronic search (PubMed, SciFinder, Google Scholar, Web of Science, and CNKI), as well as from master's dissertations, doctoral dissertations, and Chinese Pharmacopoeia. Results. Both active ingredients and herbs could exert prevention and treatment against SCI, which is linked to antioxidant, anti-inflammatory, neuroprotective, or antiapoptosis effects. The detailed information of six active natural ingredients (i.e., curcumin, resveratrol, epigallocatechin gallate, ligustrazine, quercitrin, and puerarin) and five commonly used herbs (i.e., Danshen, Ginkgo, Ginseng, Notoginseng, and Astragali Radix) was elucidated and summarized. Conclusions. As an important supplementary treatment, TCM may provide benefits in repair of injured spinal cord. With a general consensus that future clinical approaches will be diversified and a combination of multiple strategies, TCM is likely to attract greater attention in SCI treatment.

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“…The active components of Eleutherococcus senticosus, the eleutherosides, were initially coded from A to F [12], and years later, Hikino et al (1986) [13] studied seven eleutherosides coded as A, B, C, D, E, F and G, and through acid hydrolysis of these components, obtained the formation of glycosides, such as rhamnose, arabinose, xylose, mannose, galactose and glucose.…”

Section: Active Components Of Eleutherococcus Senticosusmentioning

confidence: 99%

<i>Eleutherococcus senticosus</i>: Studies and effects

Arouca¹,

Kassisse²

2013

Health

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Ginseng is one of the most popular herbal supplements in the world. It is a plant widely used in folk and traditional medicines for cardiovascular, immune, nervous and endocrine systems, and according to the researchers, it has the ability to increase the non-specific resistance state, which characterizes it as an adaptogenic substance. There are different species of ginseng, such as the American, Chinese, Korean and Japanese ginseng; the Korean species (Panax ginseng) is being used for thousands of years as a tonic, prophylactic and "restorative" agent, with powerful antioxidant properties. For a long time, its use was empirical, because people used to believe that it was a panacea that promoted longevity, with beneficial effects for the treatment of physical fatigues. Nowadays, the active components of Eleutherococcus senticosus are well described, however, there are no data on the quantity of a certain class of these secondary compounds produced in each species. Although the Eleutherococcus senticosus extract may contain several substances, including vitamins, minerals, cellulose, and ethanol, the substances responsible for inducing various physiological responses are the eleutherosides (in the root) and ciwujianosides (in the leaf). As Eleutherococcus senticosus receives great attention by showing that its active components can provide protection against oxidative stress, among other benefits, contributing to health and the prevention and treatment of diseases, such as diabetes, cancer, cardiovascular disease and inflammation. The purpose of this article is to describe the main, adverse and toxicological effects of Eleutherococcus senticosus recently related in the literature .

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Glycosides from ginseng roots

Cited by 30 publications

References 1 publication

Systems-level mechanisms of action of Panax ginseng: a network pharmacological approach

Systems-level mechanisms of action of Panax ginseng: a network pharmacological approach

Therapeutic Effects of Traditional Chinese Medicine on Spinal Cord Injury: A Promising Supplementary Treatment in Future

<i>Eleutherococcus senticosus</i>: Studies and effects

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Glycosides from ginseng roots

Cited by 30 publications

References 1 publication

Systems-level mechanisms of action of Panax ginseng: a network pharmacological approach

Systems-level mechanisms of action of Panax ginseng: a network pharmacological approach

Therapeutic Effects of Traditional Chinese Medicine on Spinal Cord Injury: A Promising Supplementary Treatment in Future

&lt;i&gt;Eleutherococcus senticosus&lt;/i&gt;: Studies and effects

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<i>Eleutherococcus senticosus</i>: Studies and effects