Glycosides from Natural Sources in the Treatment of Diabetes Mellitus

Adki, Kaveri M.; Kulkarni, Yogesh A.

doi:10.1007/978-981-15-8791-7_5

Cited by 6 publications

(4 citation statements)

References 67 publications

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“…The effects of glycoside on insulin secretion have previously been reported in INS-1 cells and isolated mouse islets [68,69]. In addition, glycoside such as stevioside, rutin, and puerarin have been reported for antidiabetic activity [70].…”

Section: Discussionmentioning

confidence: 96%

Chemical Constituents from the Roots of Angelica reflexa That Improve Glucose-Stimulated Insulin Secretion by Regulating Pancreatic β-Cell Metabolism

et al. 2023

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The aim of this study was to discover bioactive constituents of Angelica reflexa that improve glucose-stimulated insulin secretion (GSIS) in pancreatic β-cells. Herein, three new compounds, namely, koseonolin A (1), koseonolin B (2), and isohydroxylomatin (3), along with 28 compounds (4–31) were isolated from the roots of A. reflexa by chromatographic methods. The chemical structures of new compounds (1–3) were elucidated through spectroscopic/spectrometric methods such as NMR and HRESIMS. In particular, the absolute configuration of the new compounds (1 and 3) was performed by electronic circular dichroism (ECD) studies. The effects of the root extract of A. reflexa (KH2E) and isolated compounds (1–31) on GSIS were detected by GSIS assay, ADP/ATP ratio assay, and Western blot assay. We observed that KH2E enhanced GSIS. Among the compounds 1–31, isohydroxylomatin (3), (−)-marmesin (17), and marmesinin (19) increased GSIS. In particular, marmesinin (19) was the most effective; this effect was superior to treatment with gliclazide. GSI values were: 13.21 ± 0.12 and 7.02 ± 0.32 for marmesinin (19) and gliclazide at a same concentration of 10 μM, respectively. Gliclazide is often performed in patients with type 2 diabetes (T2D). KH2E and marmesinin (19) enhanced the protein expressions associated with pancreatic β-cell metabolism such as peroxisome proliferator-activated receptor γ, pancreatic and duodenal homeobox 1, and insulin receptor substrate-2. The effect of marmesinin (19) on GSIS was improved by an L-type Ca2+ channel agonist and K+ channel blocker and was inhibited by an L-type Ca2+ channel blocker and K+ channel activator. Marmesinin (19) may improve hyperglycemia by enhancing GSIS in pancreatic β-cells. Thus, marmesinin (19) may have potential use in developing novel anti-T2D therapy. These findings promote the potential application of marmesinin (19) toward the management of hyperglycemia in T2D.

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Section: Discussionmentioning

confidence: 96%

Chemical Constituents from the Roots of Angelica reflexa That Improve Glucose-Stimulated Insulin Secretion by Regulating Pancreatic β-Cell Metabolism

et al. 2023

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“…Glycosides related to puerarin, gymnemic acid 1rutin, and stevioside have been stated for noteworthy antidiabetic activity. Aglycones like christinin, strictinin, and securigenin have been conveyed for their antidiabetic activity [19]. The study on relations of cardiac glycosides with the nuclear receptor superfamily of transcription factors triggered by fewer molecular ligands such as hormones that control several purposes of cells and organisms.…”

Section: Phytochemicalmentioning

confidence: 99%

Metabolite Profiling Foamy Substance of Cucumis sativus L. white local cultivar studied by HR-LCMS

K. Latha

2024

Int Res J Adv Engg Mgt

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Cucumis sativus L. belong to Cucurbitaceous. The Phytochemical profiling of white foamy substance was performed using HR-LCMS, details of projecting compounds with MS spectra, peak list, and compound structure were studied. The prominent constituent analysis (PCA) of the investigative data displayed the existence of Triterpenes: Gitoxigenin (7.76ppm), Strophanthidin(13.79ppm), Cucurbita in-C (-0.8ppm), Cucurbita in-E(5.53ppm), and Cardiac glycosides: and Digitoxigenin(-2.13ppm) in 10µl of the loaded sample.100 other composites were identified by accurate mass of Q-TOF/MS and confirmed by database compounds (IRM calibration) which comprises, abscisic acid amino acids, fatty acids pyridylactic acid etc. Strophanthidin in the premier attention in the white foamy extract is a noteworthy finding where it has interaction with various proteins in biochemical reactions. This study reports the customary implication of removing white foamy substances before slicing for ingestion. It is used as both vegetables as well as fruit in Indian traditional medicine. It is a source of bioactive compounds.

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“…Saponin helps lower blood glucose levels by blocking the enzymes that convert disaccharides to monosaccharides [28]. Glycosides help stimulate insulin secretion and inhibit αamylase and α-glucosidase [29]. Triterpenes have the ability to block glucose metabolism enzymes, prevent diabetic complications, and regulate plasma glucose and insulin levels [30].…”

Section: Phytochemicals Of the Reported Ethnomedicinal Plantsmentioning

confidence: 99%

Ethnomedicinal Plants Used by the Pnar Tribes of Meghalaya for the Treat-ment of Diabetes Mellitus

Bamon,

Lalnundanga

2023

JTLS

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Diabetes mellitus is the world’s major public health issue and has been dubbed the “Silent Epidemic” of the twenty-first century. This is the first ethnobotanical exploration to document the folk medicinal usage of plants with therapeutic antidiabetic properties by the Pnar tribes of East Jaintia Hills, Meghalaya. Forty-one practitioners and knowledgeable people were interviewed using a semi-structured questionnaire. Field inventories were then conducted to collect plant material for botanical identification. In this study, 51 plant species belonging to 34 families and 45 genera have been identified. This study indicates that herbs were the most prevalent living form used (N = 23) for the treatment. Rhus semialata is one of the most frequently cited medicinal plants, with a Relative Frequency of Citation (RFC) of 0.73. Moreover, the details about the phytochemicals and the pharmacological activities of identified plant species have been reviewed and disclosed. Agricultural expansion, deforestation, urbanization, and unscientific exploitation of the forests were cited most when respondents were asked about the threat to medicinal plants. Of the 51 plant species, 12 are included on the IUCN Red List. Therefore, this documentation of indigenous plants would create awareness about the importance of medicinal plants and their conservation and protection.

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Glycosides from Natural Sources in the Treatment of Diabetes Mellitus

Cited by 6 publications

References 67 publications

Chemical Constituents from the Roots of Angelica reflexa That Improve Glucose-Stimulated Insulin Secretion by Regulating Pancreatic β-Cell Metabolism

Chemical Constituents from the Roots of Angelica reflexa That Improve Glucose-Stimulated Insulin Secretion by Regulating Pancreatic β-Cell Metabolism

Metabolite Profiling Foamy Substance of Cucumis sativus L. white local cultivar studied by HR-LCMS

Ethnomedicinal Plants Used by the Pnar Tribes of Meghalaya for the Treat-ment of Diabetes Mellitus

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